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US5026716A
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Method of treatment of anxiety and anxio-depressive disorders
Assignee: Sanofi Aventis France
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Filing: 1989-11-17
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Granted: 1991-06-25
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Expires: 2009-11-17
Abstract
Abstract A method of treatment of anxiety and depression in mammals is described which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine derivative of formula I ##STR1## wherein Alk represents a straight or branched (C 1 -C 4 )alkylene chain and R is selected from the group consisting of cyano, acetyl, (C 3 -C 7 )cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.
Inventors
- 👤 Alberto Bianchetti
- 👤 Gerard Le Fur
- 👤 Jacques Simiand
- 👤 Philippe Soubrie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61P; A61P25/00; A61P25/20
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
73 words
A method of treatment of anxiety and anxio-depressive disorders in mammals which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine of general formula I ##STR4## wherein Alk represents a straight or branched (C 1 -C 4 )alkylene chain and R is a radical selected from the group consisting of cyano, acetyl, (C 3 -C 7 )cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
73 words
A method of treatment of anxiety and anxio-depressive disorders in mammals which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine of general formula I ##STR4## wherein Alk represents a straight or branched (C 1 -C 4 )alkylene chain and R is a radical selected from the group consisting of cyano, acetyl, (C 3 -C 7 )cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
31 words
The method of treatment of claim 1, wherein in formula I Alk is ethylene and R represents a radical selected from the group consisting of 2-pyridyl, 4-pyridyl, 1-oxide-4-pyridyl, cyclohexyl and 2-naphthyl.
Claim 4
Dependent Claim
21 words
The method of treatment of claim 1, wherein in formula I Alk is ethylene, propylene, or butylene and R is cyano.
Claim 5
Dependent Claim
11 words
The method of treatment of claim 2, wherein R is 2-naphthyl.
Claim 6
Dependent Claim
16 words
The method of treatment of claim 4, which comprises administering an effective amount of 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 7
Dependent Claim
17 words
The method of treatment of claim 1, wherein the effective amount is from 0.2 to 150 mg/day.
Claim 8
Dependent Claim
18 words
The method of treatment of claim 4, wherein the effective amount is divided in 2 or 3 doses.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-24 | 1994-12-24 | 1995-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-24 | 1998-12-24 | 1999-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-24 | 2002-12-24 | 2003-06-25 | $7700.00 | Window Closed / Lapsed |