Patent US5023245A successfully refreshed from Google Patents.
US5023245A
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Improved niacin formulation
Assignee: Hauser-Kuhrts Inc
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Filing: 1989-11-22
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Granted: 1991-06-11
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Expires: 2009-11-22
Abstract
Abstract An antihyperlipidemic pharmaceutical or dietary supplement composition for oral use consisting essentially of a combination of niacin and a gel-forming dietary fiber, and a method of lowering cholesterol levels with such oral pharmaceutical composition, or by the simultaneous oral administration of the active ingredients thereof, which eliminates the usual undesirable flushing and itching side effects of niacin while effectively lowering cholesterol levels, especially LDL cholesterol levels, is disclosed.
Inventors
- 👤 Eric H. Kuhrts
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 03:17
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A23; A23L; A23L2/00; A23L2/385; A23L2/39; A61K31/00; A61K31/70; A61K31/715; A61K33/00; A61K33/06; A61K33/10; A61K36/00; A61K36/18; A61K36/185; A61K36/48; A61K36/481; A61K36/483; A61K36/577; A61K36/68; A61K47/00; A61K47/06; A61K47/08; A61K47/12
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
30 words
An oral antihyperlipidemic composition of nicotinic acid, having a reduced flushing effect, comprising an effective antihyperlipidemic amount of nicotinic acid and an effective cutaneous-flushing-reducing amount of a gel-forming dietary fiber.
Claim 2
Dependent Claim
30 words
An oral antihyperlipidemic composition of nicotinic acid, having a reduced flushing effect, comprising an effective antihyperlipidemic amount of nicotinic acid and an effective cutaneous-flushing-reducing amount of a gel-forming dietary fiber.
Claim 3
Dependent Claim
17 words
A composition of claim 1 wherein the composition contains at least about 50 mg of nicotinic acid.
Claim 4
Dependent Claim
17 words
A composition of claim 1 wherein the amount of dietary fiber is at least about 250 mg.
Claim 5
Dependent Claim
22 words
A composition of claim 2 wherein the amount of dietary fiber is at least about 400 mg, in capsule or tablet form.
Claim 6
Dependent Claim
20 words
A composition of claim 2 wherein the amount of dietary fiber is at least about 400 mg, and an antacid.
Claim 7
Dependent Claim
19 words
A composition of claim 4 comprising also an orally-ingestible non-toxic mineral salt capable of dissolution in the gastric fluids.
Claim 8
Dependent Claim
14 words
A composition of claim 6 wherein the mineral salt is a physiologially-acceptable magnesium salt.
Claim 9
Dependent Claim
23 words
A composition of claim 6, wherein the mineral salt is selected from the group consisting of calcium carbonate, magnesium carbonate, and potassium carbonate.
Claim 10
Dependent Claim
44 words
A composition of claim 1, wherein the active ingredients are in granular form and comprising also a quantity of a food-grade acid in powder or granular form which is effective in extending the time for gelation of the resulting mix upon addition of water.
Claim 11
Dependent Claim
25 words
A composition of claim 9, wherein the food-grade acid is selected from the group consisting of citric acid, ascorbic acid, tartaric acid, and malic acid.
Claim 12
Dependent Claim
22 words
A composition of claim 8 comprising about 400-500 mg gel-forming dietary fiber about 80-150 mg nicotinic acid about 80-100 mg magnesium carbonate.
Claim 13
Dependent Claim
52 words
Method for reducing the cutaneous flushing caused by the administration of an effective antihyperlipidemic amount of nicotinic acid to a patient suffering from hyperlipidemia, comprising the step of simultaneously orally administering to said patient an effective cutaneous-flushing-reducing amount of a physiologically-acceptable gel-forming dietary fiber and an effective antihyperlipidemic amount of nicotinic acid.
Claim 14
Dependent Claim
52 words
Method for reducing the cutaneous flushing caused by the administration of an effective antihyperlipidemic amount of nicotinic acid to a patient suffering from hyperlipidemia, comprising the step of simultaneously orally administering to said patient an effective cutaneous-flushing-reducing amount of a physiologically-acceptable gel-forming dietary fiber and an effective antihyperlipidemic amount of nicotinic acid.
Claim 15
Dependent Claim
23 words
Method of claim 12 wherein the nicotinic acid and dietary fiber are in the form of a pharmaceutical composition containing both active ingredients.
Claim 16
Dependent Claim
14 words
Method of claim 13 wherein the active ingredients are in capsule or tablet form.
Claim 17
Dependent Claim
12 words
Method of claim 14 comprising also administration of a physiologically-acceptable mineral salt.
Claim 18
Dependent Claim
21 words
Method of claim 13, wherein a single dose comprises about 300-1000 mg of niacin and about 1.5-6 g of dietary fiber.
Claim 19
Dependent Claim
28 words
Method of claim 15, wherein a single dose comprises about 300-1000 mg niacin, about 1.5-6 g of dietary fiber, and about 300-500 mg of a physiologically-acceptable mineral salt.
Claim 20
Dependent Claim
23 words
Method of claim 12 wherein a dosage unit comprises at least about 250 mg dietary fiber and at least about 50 mg niacin.
Claim 21
Dependent Claim
24 words
Method of claim 16 wherein a single dose comprises at least about 2 g dietary fiber and at least about 350 mg of niacin.
Claim 22
Dependent Claim
30 words
Method of claim 15 wherein a daily dose comprises at least about 6 g dietary fiber, at least about 1 g niacin, and at least about 1 g magnesium carbonate.
Claim 23
Dependent Claim
21 words
Method of claim 12, wherein an orally-ingestible non-toxic mineral salt capable of dissolution in the gastric fluid is simultaneously orally administered.
Claim 24
Dependent Claim
14 words
Method of claim 21 wherein the non-toxic mineral salt is a physiologically-acceptable magnesium salt.
Claim 25
Dependent Claim
12 words
Method of claim 22 wherein the physiologically-acceptable magnesium salt is magnesium carbonate.
Claim 26
Dependent Claim
50 words
Method of claim 12, wherein the active ingredients are in granular form and wherein a quantity of a food-grade acid also in powder or granular form which is effective in extending the time for gelation of the resulting mix upon addition of water is also concurrently or simultaneously orally administered.
Claim 27
Dependent Claim
24 words
Method of claim 24, wherein the food-grade acid is selected from the group consisting of citric acid, ascorbic acid, tartaric acid, and malic acid.
Claim 28
Dependent Claim
22 words
Method of claim 21, wherein the mineral salt is selected from the group consisting of calcium carbonate, magnesium carbonate, and potassium carbonate.
Claim 29
Dependent Claim
13 words
Method of claim 15, wherein the mineral salt is a physiologically-acceptable magnesium salt.
Claim 30
Dependent Claim
25 words
A composition of claim 6, wherein the mineral salt is a pharmacologically-acceptable mineral salt capable of dissolution in the gastric fluid with release of gas.
Claim 31
Dependent Claim
11 words
A composition of claim 28, wherein the gas is carbon dioxide.
Claim 32
Dependent Claim
24 words
Method of claim 21, wherein the mineral salt is a pharmacologically-acceptable mineral salt capable of dissolution in the gastric fluid with release of gas.
Claim 33
Dependent Claim
10 words
Method of claim 30, wherein the gas is carbon dioxide.
Claim 34
Dependent Claim
13 words
Composition of claim 29, wherein the mineral salt is a carbonate or bicarbonate.
Claim 35
Dependent Claim
13 words
Method of claim 31, wherein the mineral salt is a carbonate or bicarbonate.
Claim 36
Dependent Claim
22 words
A composition of claim 9, comprising also a pharmacologically-acceptable mineral salt capable of dissolution in the gastric fluid with release of gas.
Claim 37
Dependent Claim
14 words
A composition of claim 34, wherein the mineral salt is a carbonate or bicarbonate.
Claim 38
Dependent Claim
23 words
Method of claim 12, wherein a daily dose comprises at least about 6 g dietary fiber and at least about 1 g niacin.
Claim 39
Dependent Claim
22 words
A composition of claim 1, wherein the ratio of guar gum by weight to nicotinic acid by weight is at least 3:1.
Claim 40
Dependent Claim
21 words
Method of claim 12, wherein the ratio of guar gum by weight to nicotinic acid by weight is at least 3:1.
Claim 41
Dependent Claim
24 words
A composition of claim 37, wherein the ratio of guar gum by weight to nicotinic acid by weight is about 3:1 to about 8.3:1.
Claim 42
Dependent Claim
23 words
Method of claim 38, wherein the ratio of guar gum by weight to nicotinic acid by weight is about 3:1 to about 8.3:1.
References Cited (Backward Citations)
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