Patent US5022988A successfully refreshed from Google Patents.
US5022988A
Expired / Lapsed
US
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Device for plasma modification--composition and remodeling
Assignee: Applied Immune Sciences Inc
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Filing: 1988-10-20
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Granted: 1991-06-11
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Expires: 2008-10-20
Abstract
Abstract Compositions and devices are provided for the specific removal of components of plasma in efficient and economical ways. The devices provide for a tortuous path of the plasma through a high surface material to which is bound a binding compound for removal of the fluid component. The devices find particular application with plasma, in diagnosis, therapy, and for production of specific physiologically active materials.
Inventors
- 👤 Thomas B. Okarma
- 👤 Chin-Hai Chang
- 👤 Brian R. Clark
- 👤 L. Bernard Lerch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:40
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61M1/3616; Y; Y10; Y10S; Y10S210/00; Y10S210/902; Y10S210/908; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10S530/814; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
150 words
A device for modifying plasma by removing or remodeling at least one plasma component, which plasma component is a member of a specific binding pair, said device having a predetermined volume rating, said device comprising: a container of a biocompatible material having an entry and an exit port and an extended flow path between said ports; a high surface area biocompatible cellulosic porous solid support comprising a member of said specific binding pair substantially uniformly and irreversibly bonded to said support in an amount sufficient to bind the reciprocal member of said specific binding pair at the volume rating of said device, wherein said flow path directs said plasma through said porous support; said porous support comprising membrane sheets in stacks of at least two sheets, there being at least two stacks; separating said stacks are alternating U-rings in alternate directions to alternately direct the flow path in opposite directions.
Claim 2
Independent Claim
150 words
A device for modifying plasma by removing or remodeling at least one plasma component, which plasma component is a member of a specific binding pair, said device having a predetermined volume rating, said device comprising: a container of a biocompatible material having an entry and an exit port and an extended flow path between said ports; a high surface area biocompatible cellulosic porous solid support comprising a member of said specific binding pair substantially uniformly and irreversibly bonded to said support in an amount sufficient to bind the reciprocal member of said specific binding pair at the volume rating of said device, wherein said flow path directs said plasma through said porous support; said porous support comprising membrane sheets in stacks of at least two sheets, there being at least two stacks; separating said stacks are alternating U-rings in alternate directions to alternately direct the flow path in opposite directions.
Claim 3
Dependent Claim
20 words
A device according to claim 1, wherein said cellulosic support is a cellulose acetate coating on a polyester membrane carrier.
Claim 4
Dependent Claim
21 words
A device according to claim 2, wherein said specific binding member is a protein bonded to said support by reductive amination.
Claim 5
Dependent Claim
13 words
A device according to claim 3, wherein said protein specifically binds to immunoglobulin.
Claim 6
Dependent Claim
13 words
A device according to claim 4, wherein said protein is recombinant protein A.
Claim 7
Dependent Claim
14 words
A device according to claim 3, wherein said protein is a membrane surface receptor.
Claim 8
Dependent Claim
14 words
A device according to claim 6, wherein said membrane surface receptor is acetylcholine receptor.
Claim 9
Dependent Claim
23 words
A device according to claim 2, comprising in combination in fluid receiving relationship with said exit port a silicic acid anaphylatoxin removing compartment.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-10 | 1994-12-10 | 1995-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-10 | 1998-12-10 | 1999-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-10 | 2002-12-10 | 2003-06-11 | $7700.00 | Window Closed / Lapsed |