Patent US5019260A successfully refreshed from Google Patents.
US5019260A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Filtration media with low protein adsorbability
Assignee: Pall Corp
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Filing: 1989-12-07
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Granted: 1991-05-28
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Expires: 2009-12-07
Abstract
Abstract A porous polymeric medium having a low affinity for amide group-containing and adjuvant-containing materials is provided comprising a porous polyvinylidene difuoride substrate and a surface-modifying polymeric material having a low affinity for amide group-containing materials formed in situ at and covalently bonded to the surface of the porous polyvinylidene difluoride substrate, the surface-modifying polymeric material being formed from a monofunctional monomer having at least one hydroxyl group. Another embodiment that provides a porous polymeric medium having a low affinity for amide group-containing materials employs a supplemental monomer in combination with the monofunctional monomer having at least one hydroxyl group to form the surface-modifying polymeric material. The supplmental monomer or comonomer used is one which, when formed as a homopolymer, has a high affinity for amide group-containing materials.
Inventors
- 👤 Thomas C. Gsell
- 👤 Isaac Rothman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:46
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0093; B01D67/00931; B01D39/00; B01D39/14; B01D39/16; B01D71/00; B01D71/06; B01D71/30; B01D71/32; B01D71/34; C; C08; C08J; C08J7/00; C08J7/12; C08J7/16; C08J7/18; C08J9/00; C08J9/36; C08J9/40; C08J9/405; B01D2323/00; B01D2323/38; B01D2323/385; C08J2327/00; C08J2327/02; C08J2327/12; C08J2327/16; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
62 words
A porous polymeric medium having a low affinity for amide group-containing materials comprising: a porous polyvinylidene difluoride substrate; and a surface-modifying polymeric material having a low affinity for amide group-containing materials formed in situ at and covalently bonded to the surface of said polyvinylidene difluoride substrate, said surface-modifying polymeric material being derived from a monofunctional monomer having at least one hydroxyl group.
Claim 2
Dependent Claim
62 words
A porous polymeric medium having a low affinity for amide group-containing materials comprising: a porous polyvinylidene difluoride substrate; and a surface-modifying polymeric material having a low affinity for amide group-containing materials formed in situ at and covalently bonded to the surface of said polyvinylidene difluoride substrate, said surface-modifying polymeric material being derived from a monofunctional monomer having at least one hydroxyl group.
Claim 3
Dependent Claim
24 words
The porous polymeric medium of claim 1 wherein said surface-modifying polymeric material is bonded directly to the surface of said porous polyvinylidene difluoride substrate.
Claim 4
Dependent Claim
22 words
The porous polymeric medium of claim 1 wherein said monomer from which said surface-modifying polymeric material is derived, comprises an unsaturated compound.
Claim 5
Dependent Claim
37 words
The porous polymeric medium of claim 3 wherein said surface-modifying polymeric material is derived from a combination of said unsaturated monofunctional monomer having at least one hydroxyl group and a minor amount of a supplemental unsaturated monomer.
Claim 6
Dependent Claim
25 words
The porous polymeric medium of claim 4 wherein said supplemental unsaturated monomer comprises a monomer whose homopolymer exhibits a high affinity toward amide group-containing materials.
Claim 7
Dependent Claim
24 words
The porous polymeric medium of claim 4 wherein said supplemental unsaturated monomer contains an ionic or ionizable group in addition to said unsaturated group.
Claim 8
Dependent Claim
22 words
The porous polymeric medium of claim 6 wherein said supplemental unsaturated monomer comprises a carboxylic acid, sulfonic acid or a phosphonic acid.
Claim 9
Dependent Claim
17 words
The porous polymeric medium of claim 6 wherein said supplemental unsaturated monomer comprises an unsaturated carboxylic acid.
Claim 10
Dependent Claim
17 words
The porous polymeric medium of claim 8 wherein said supplemental unsaturated monomer comprises acrylic or methacrylic acid.
Claim 11
Dependent Claim
22 words
The porous polymeric medium of claim 4 wherein said supplemental unsaturated monomer includes a hydrophobic group in addition to said unsaturated group.
Claim 12
Dependent Claim
16 words
The porous polymeric medium of claim 10 wherein said hydrophobic group comprises a lower alkyl group.
Claim 13
Dependent Claim
18 words
The porous polymeric medium of claim 10 wherein said supplemental unsaturated monomer comprises an alkyl acrylate or methacrylate.
Claim 14
Dependent Claim
14 words
The porous polymeric medium of claim 10 wherein said supplemental unsaturated monomer comprises methylmethacrylate.
Claim 15
Dependent Claim
23 words
The porous polymeric medium of claim 1 wherein said monomer from which said surface-modifying polymeric material is derived comprises an ethylenically unsaturated compound.
Claim 16
Dependent Claim
17 words
The porous polymeric medium according to claim 14 wherein said monomer is an hydroxyalkyl acrylate or methacrylate.
Claim 17
Dependent Claim
18 words
The porous polymeric medium according to claim 15 wherein the hydroxyalkyl group contains 2 to 5 carbon atoms.
Claim 18
Dependent Claim
33 words
The porous polymeric medium according to claim 14 wherein said monomer is 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, 3-hydroxyprop-2-yl acrylate, 3-hydroxyprop-2-yl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl methacrylate or mixtures of at least two the foregoing monomers.
Claim 19
Dependent Claim
21 words
The porous polymeric medium according to claim 14 wherein said monomer is at least one of 3-hydroxyprop-2-yl acrylate and 2-hydroxypropyl acrylate.
Claim 20
Dependent Claim
21 words
The porous polymeric medium according to claim 14 wherein said monomer is at least one of 3-hydroxyprop-2-yl methacrylate and 2-hydroxypropyl methacrylate.
Claim 21
Dependent Claim
14 words
The porous polymeric medium according to claim 14 wherein said monomer is hydroxyethyl methacrylate.
Claim 22
Dependent Claim
21 words
The porous polymeric medium of claim 1 wherein said surface modifying polymeric material comprises a material rich in pendant hydroxyl groups.
Claim 23
Dependent Claim
14 words
The porous polymeric medium of claim 1 wherein said porous polyvinylidene difluoride is microporous.
Claim 24
Dependent Claim
18 words
The porous polymeric medium of claim 1 wherein said porous polyvinylidene difluoride substrate and said medium are microporous.
Claim 25
Dependent Claim
15 words
The porous polymeric medium of claim 1 wherein said amide group-containing material comprises proteinaceous material.
Claim 26
Dependent Claim
32 words
The porous polymeric medium of claim 24 wherein said medium has an adsorption of proteinaceous material measured by the Bovine Serum Albumin Adsorption Test of less than 100 micrograms per square centimeter.
Claim 27
Dependent Claim
36 words
The porous polymeric medium according to claim 1 wherein said monomer is a monomer capable of polymerizing and forming a polymer and covalently bonding to said porous polyvinylidene difluoride substrate under the influence of ionizing radiation.
Claim 28
Dependent Claim
53 words
The porous polymeric medium according to claim 1 wherein said polyvinylidene difluoride substrate and said medium are microporous, said monomer is 2-hydroxypropyl or 3-hydroxyprop-2-yl methacrylate or hydroxyethyl methacrylate and said medium has an adsorption of proteinaceous material as measured by the Bovine Serum Albumin Adsorption test of less than 100 micrograms/cm 2 .
Claim 29
Independent Claim
78 words
A method of producing a porous polymeric medium having low amide group-containing sorbability comprising: contacting a porous polyvinylidene difluoride substrate with a solution of a monofunctional monomeric compound having at least one hydroxyl group and capable of forming a polymer having a low affinity for amide group-containing material; and exposing said polyvinylidene difluoride substrate and said monomeric compound to ionizing radiation to effect polymerization of said monomeric compound at the surface of said substrate to form said medium.
Claim 30
Independent Claim
78 words
A method of producing a porous polymeric medium having low amide group-containing sorbability comprising: contacting a porous polyvinylidene difluoride substrate with a solution of a monofunctional monomeric compound having at least one hydroxyl group and capable of forming a polymer having a low affinity for amide group-containing material; and exposing said polyvinylidene difluoride substrate and said monomeric compound to ionizing radiation to effect polymerization of said monomeric compound at the surface of said substrate to form said medium.
Claim 31
Dependent Claim
49 words
The method of producing a porous polymeric medium of claim 28 wherein said monofunctional monomeric compound having at least one hydroxyl group comprises an ethylenically unsaturated compound and said solution includes a major amount of said monofunctional monomeric compound and further includes a minor amount of supplemental unsaturated monomer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-27 | 1994-11-26 | 1995-05-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-27 | 1998-11-26 | 1999-05-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-27 | 2002-11-26 | 2003-05-28 | $7700.00 | Window Closed / Lapsed |