Patent US5008099A successfully refreshed from Google Patents.
US5008099A
Expired / Lapsed
US
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Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
Assignee: Amersham Health Salutar Inc
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Filing: 1990-04-17
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Granted: 1991-04-16
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Expires: 2010-04-17
Abstract
Abstract The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably 123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects or the invention.
Inventors
- 👤 Steven C. Quay
- 👤 Scott M. Rocklage
- 👤 Warren K. Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:08
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6893; G01N33/6896; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0404; A61K51/0406; C; C07; C07C; C07C309/00; C07C309/01; C07C309/28; C07C309/45; C07C309/47; C07C309/49; C07C309/50; C07D; C07D277/00; C07D277/60; C07D277/62; C07D277/64; C07D277/66; C09; C09B; C09B29/00; C09B29/0003; C09B29/0011; C09B29/24; C09B29/28; C09B29/30; C09B35/00; C09B35/02; C09B35/039; C09B35/08; C09B35/10; C09B35/16; C09B35/20; C09B43/00; C09B43/40; A61K2123/00; G01N2800/00; G01N2800/28; G01N2800/2814; G01N2800/2821
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
78 words
An amyloid binding diazo compound of Formula III or Formula IV or a water-soluble non-toxic salt thereof: ##STR13## wherein: I * is a radioactive iodine moiety; R 40 R 41 are hydrogen hydroxy or amino, and R 40 and R 41 are not the same group; R 42 , R 43 , R 44 , R 45 and R 46 are sulfo; and sulfo is not present on adjacent carbons; and R 47 is hydrogen, methyl or carboxy.
Claim 2
Dependent Claim
78 words
An amyloid binding diazo compound of Formula III or Formula IV or a water-soluble non-toxic salt thereof: ##STR13## wherein: I * is a radioactive iodine moiety; R 40 R 41 are hydrogen hydroxy or amino, and R 40 and R 41 are not the same group; R 42 , R 43 , R 44 , R 45 and R 46 are sulfo; and sulfo is not present on adjacent carbons; and R 47 is hydrogen, methyl or carboxy.
Claim 3
Independent Claim
56 words
A method for determining the presence and location of an amyloid deposit in a body area of a patient comprising intravenous administration of an imaging effective quantity of a compound containing a radioactive iodine group of any one of claims 16, 18, 19 or 24 to the patient, and sensing radiation emitted from the body area.
Claim 4
Independent Claim
52 words
A method for determining the presence and location of an amyloid deposit in a body area of a patient comprising intravenous administration of an imaging effective quantity of a compound containing a radioactive iodine group of anyone of claims 16-22 inclusive to the patient, and sensing radiation emitted from the body area.
Claim 5
Dependent Claim
10 words
4-Amino-3-(1- 123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 6
Dependent Claim
10 words
4-Amino-3-(1- 123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 7
Dependent Claim
10 words
4-Amino-3-(1- 125 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 8
Dependent Claim
10 words
4-Amino-3-(1- 125 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 9
Dependent Claim
11 words
4-Amino-5-hydroxy-3-(1- 123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water soluble, non-toxic salt thereof.
Claim 10
Dependent Claim
11 words
4-Amino-5-hydroxy-3-(1- 123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water soluble, non-toxic salt thereof.
Claim 11
Dependent Claim
11 words
4-Amino-5-hydroxy-3-(1- 125 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water soluble, non-toxic salt thereof.
Claim 12
Dependent Claim
11 words
4-Amino-5-hydroxy-3-(1- 125 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water soluble, non-toxic salt thereof.
Claim 13
Dependent Claim
10 words
4-Amino-5-hydroxy-6-(1- 125 I-phen-4-yldiazo)-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 14
Dependent Claim
10 words
4-Amino-5-hydroxy-6-(1- 125 I-phen-4-yldiazo)-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 15
Dependent Claim
10 words
4-Amino-5-hydroxy-63-(1- 123 I-phen-4-yldiazo)-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 16
Dependent Claim
10 words
4-Amino-5-hydroxy-63-(1- 123 I-phen-4-yldiazo)-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 17
Dependent Claim
10 words
4-Amino-5-hydroxy-6-(1- 125 I-phen-4-yldiazo-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 18
Dependent Claim
10 words
4-Amino-5-hydroxy-6-(1- 125 I-phen-4-yldiazo-naphthylene-1,3-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 19
Dependent Claim
10 words
1-Amino-8-hydroxy-7-(1- 123 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 20
Dependent Claim
10 words
1-Amino-8-hydroxy-7-(1- 123 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 21
Dependent Claim
10 words
1-Amino-8-hydroxy-7-(1- 125 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 22
Dependent Claim
10 words
1-Amino-8-hydroxy-7-(1- 125 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 23
Dependent Claim
10 words
1-Amino-8-hydroxy-2-(1- 123 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 24
Dependent Claim
10 words
1-Amino-8-hydroxy-2-(1- 123 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 25
Dependent Claim
10 words
1-Amino-8-hydroxy-2-(1- 125 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 26
Dependent Claim
10 words
1-Amino-8-hydroxy-2-(1- 125 I-phen-4-yldiazo)-naphthylene-3,6-disulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 27
Dependent Claim
10 words
4-Amino-3-(1- 123 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 28
Dependent Claim
10 words
4-Amino-3-(1- 123 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 29
Dependent Claim
10 words
4-Amino-3-(1- 125 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 30
Dependent Claim
10 words
4-Amino-3-(1- 125 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 31
Dependent Claim
10 words
4-Amino-3-(1- 123 I-phen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 32
Dependent Claim
10 words
4-Amino-3-(1- 123 I-phen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 33
Dependent Claim
10 words
4-Amino-3-(1- 125 I-phen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 34
Dependent Claim
10 words
4-Amino-3-(1- 125 I-phen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 35
Dependent Claim
10 words
4-Amino-3-(1- 123 I-methylphen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 36
Dependent Claim
10 words
4-Amino-3-(1- 123 I-methylphen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 37
Dependent Claim
10 words
4-Amino-3-(1- 125 I-methylphen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 38
Dependent Claim
10 words
4-Amino-3-(1- 125 I-methylphen-3-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 39
Dependent Claim
10 words
4-Amino-3-(1-carboxy-3- 123 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 40
Dependent Claim
10 words
4-Amino-3-(1-carboxy-3- 123 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 41
Dependent Claim
10 words
4-Amino-3-(1-carboxy-3- 125 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 42
Dependent Claim
10 words
4-Amino-3-(1-carboxy-3- 125 I-phen-2-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 43
Dependent Claim
10 words
4-Amino-5-hydroxy-3-(1- 123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
Claim 44
Dependent Claim
10 words
4-Amino-5-hydroxy-3-(1- 123 I-phen-4-yldiazo)-naphthylene-1-sulfonic acid or a water-soluble, non-toxic salt thereof.
References Cited (Backward Citations)
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Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-15 | 1994-10-15 | 1995-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-15 | 1998-10-15 | 1999-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-15 | 2002-10-15 | 2003-04-16 | $7700.00 | Window Closed / Lapsed |