Patent US5001047A successfully refreshed from Google Patents.
US5001047A
Expired / Lapsed
US
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Method of preserving organs
Assignee: Individual
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Filing: 1988-07-14
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Granted: 1991-03-19
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Expires: 2008-07-14
Abstract
Abstract A method of preserving harvested viable organs for transplant is provided. The method includes the steps of preparing a brine including a cruciferous oil and a glycol, cooling the brine, and subjecting the harvested viable organ to the cooled brine in order to chill the viable organ and maintain its viability.
Inventors
- 👤 Barnet L. Liberman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 10:16
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/125
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
92 words
A method of preserving harvested viable organs of a mammalian subject for transplant comprising: preparing a brine comprising at least 0.1% by weight of cruciferous oil, between about 30 and 50% by weight of glycol, and between about 5 and 15% by weight of an inorganic salt, the balance being water; cooling the brine to a temperature between about -22° and -43.6° F.; and subjecting the harvested viable organ to a heat transfer relationship with the cooled brine in order to chill said organ and maintain its viability until it is transplanted.
Claim 2
Independent Claim
92 words
A method of preserving harvested viable organs of a mammalian subject for transplant comprising: preparing a brine comprising at least 0.1% by weight of cruciferous oil, between about 30 and 50% by weight of glycol, and between about 5 and 15% by weight of an inorganic salt, the balance being water; cooling the brine to a temperature between about -22° and -43.6° F.; and subjecting the harvested viable organ to a heat transfer relationship with the cooled brine in order to chill said organ and maintain its viability until it is transplanted.
Claim 3
Dependent Claim
22 words
The method of preserving harvested viable organs of claim 1, wherein the oil is extracted from a plant of the genus Brassica.
Claim 4
Dependent Claim
27 words
The method of preserving harvested viable organs of claim 1, wherein the oil is selected from the group consisting of rapeseed oil, mustard oil, and mixtures thereof.
Claim 5
Dependent Claim
21 words
The method of preserving harvested viable organs of claim 1, wherein the oil contains erucic acid as the single largest component.
Claim 6
Dependent Claim
20 words
The method of preserving harvested viable organs of claim 1, wherein the oil contains less than about 2% saturated components.
Claim 7
Dependent Claim
28 words
The method of preserving harvested viable organs of claim 1, wherein the oil is used in an amount between about 0.1 and 0.5% by weight of the brine.
Claim 8
Dependent Claim
16 words
The method of preserving harvested viable organs of claim 1, wherein the glycol is propylene glycol.
Claim 9
Dependent Claim
28 words
The method of preserving harvested viable organs of claim 1, wherein the glycol is present in an amount between about 35 and 40% by weight of the brine.
Claim 10
Dependent Claim
16 words
The method of preserving harvested viable organs of claim 1, wherein the salt is calcium chloride.
Claim 11
Dependent Claim
28 words
The method of preserving harvested viable organs of claim 1, wherein the salt is present in an amount between about 7 and 13% by weight of the brine.
Claim 12
Dependent Claim
28 words
The method of preserving harvested viable organs of claim 1, wherein the water is present in an amount between about 4 and 55% by weight of the brine.
Claim 13
Dependent Claim
31 words
The method of preserving harvested viable organs of claim 1, wherein the organ is subjected to a heat transfer relationship with the chilled brine by immersing the organ in the brine.
Claim 14
Dependent Claim
49 words
The method of preserving harvested viable organs of claim 1, wherein the organ is subjected to a heat transfer relationship with the cooled brine by placing the organ in a heat transfer tray and bringing the opposite side of the heat transfer tray into contact with the cooled brine.
Claim 15
Dependent Claim
55 words
The method of preserving harvested viable organs of claim 1, wherein the organ is subjected to a heat transfer relationship with the cooled brine by placing the organ and a small amount of brine into a heat transfer tray and bringing the opposite side of the heat transfer tray into contact with the cooled brine.
Claim 16
Dependent Claim
34 words
The method of preserving harvested viable organs of claim 14, wherein the heat transfer tray has a bottom and the small amount of brine at least covers the bottom of the heat transfer tray.
Claim 17
Independent Claim
118 words
A method of preserving harvested viable organs of a mammalian subject for transplant, comprising: preparing a brine comprising an effective amount of a suitable oil for increasing the chilling rate of the organ brought into a heat transfer relationship therewith so as to minimize deterioration in the cellular structure of the organ, between about 30 and 50% by weight of a glycol, and between about 5 and 15% by weight of an inorganic salt, the balance being water; cooling the brine to a temperature between about -22° and -43.6° F.; and subjecting the harvested viable organ to a heat transfer relationship with cooled brine in order to chill the organ and maintain its viability until it is transplanted.
Claim 18
Independent Claim
118 words
A method of preserving harvested viable organs of a mammalian subject for transplant, comprising: preparing a brine comprising an effective amount of a suitable oil for increasing the chilling rate of the organ brought into a heat transfer relationship therewith so as to minimize deterioration in the cellular structure of the organ, between about 30 and 50% by weight of a glycol, and between about 5 and 15% by weight of an inorganic salt, the balance being water; cooling the brine to a temperature between about -22° and -43.6° F.; and subjecting the harvested viable organ to a heat transfer relationship with cooled brine in order to chill the organ and maintain its viability until it is transplanted.
Claim 19
Dependent Claim
25 words
The method of preserving harvested viable organs of claim 16, wherein the brine includes between about 0.1 and 1% by weight of a cruciferous oil.
Claim 20
Dependent Claim
16 words
The method of preserving harvested viable organs of claim 17, wherein the oil is rapeseed oil.
Claim 21
Dependent Claim
50 words
The method of preserving harvested viable organs of claim 16, wherein the brine includes between about 0.1 and 0.5% by weight of a cruciferous oil, between about 35 and 45% by weight of a glycol, between 7 and 13% by weight of an inorganic salt and a balance of water.
References Cited (Backward Citations)
US4559298A
Cited
US4840034A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-03-18 | 1994-09-17 | 1995-03-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-18 | 1998-09-17 | 1999-03-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-18 | 2002-09-17 | 2003-03-19 | $7700.00 | Window Closed / Lapsed |