Patent US4988705A successfully refreshed from Google Patents.
US4988705A
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Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
Assignee: Merck Sharp & Dohme LLC
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Filing: 1989-02-07
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Granted: 1991-01-29
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Expires: 2009-02-07
Abstract
Abstract Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
Inventors
- 👤 Ashit K. Ganguly
- 👤 Richard J. Friary
- 👤 John H. Schwerdt
- 👤 Marvin I. Siegel
- 👤 Sidney R. Smith
- 👤 Vera A. Seidl
- 👤 Edmund J. Sybertz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 18:39
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/16; C07D471/12; C07D471/14; C07D491/00; C07D491/12; C07D491/14; C07D495/00; C07D495/12; C07D495/14
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
712 words
A compound having the structural formula I ##STR287## or a pharmaceutically acceptable salt or solvate thereof, wherein: in formula I: the dotted lines ( ) represent optional double bonds; W is ##STR288## T and V may be the same or different and each represents H, OH, alkyl, alkoxy, phenyl or substituted phenyl; in addition, T may also be F, Cl, or Br; X and M may be the same or different and each independently represents -CH(R a )- or -NA- when the dotted line attached thereto does not represent a double bond; or X and M each independently represents ═CH-- or ═N-- when the dotted line attached thereto represents a double bond; or when M is N and the dotted lines in ring t both represent double bonds, X and T together with the carbon atom of the ring t therebetween may also represent a group ##STR289## wherein X is a carbon atom and Q 0-3 represents zero, 1, 2 or 3 Q substituents as defined below; each A is independently selected from H, alkyl, CH 2 CH 2 OH, COR b , COOR e , SO 2 R b or (CH 2 ) s R c ; Z is O, S, N-R e or N(OR i ); B is alkenyl, NH 2 , COOR e , O(CO)R e , or an aryl group selected from phenyl, naphthyl, indenyl, indanyl, phenanthridinyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-triazinyl, furanyl, thienyl, benzofuranyl, indolyl, imidazolyl, pyrazolyl, triazolyl, or thiazolyl, any of which aryl groups may be substituted with up to three of any of the following substituents, Q: halogen, hydroxy, nitro, alkyl, CH 2 OH, trifluoromethyl, cyano, N(R f ) 2 , cycloalkyl, alkoxy, alkenyloxy, alkynyloxy, S(O) r R e , NHSO 2 R e , NHSO 2 CF 3 , NHCOCF 3 , SO 2 NH 2 , SO 2 NHR e , SO 2 N(R e ) 2 , COR h , O-D-COR h , or NHCOR d ; R a is H, OH, alkyl, phenyl, substituted phenyl, phenylalkyl or substituted phenylalkyl; R b is H, alkyl, phenyl, substituted phenyl, or N(R e ) 2 ; R c represents carboxyl or N(R i ) 2 ; R d represents H, alkyl, alkoxy, COR j or NHR k ; each R e independently represents alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl; each R f independently represents H or alkyl; R h represents OH, NH 2 or OR e ; each R i independently represents H or alkyl; R j represents OH or alkoxy; R k represents H or alkyl; D represents alkylene; r is 0, 1 or 2; and s is 1, 2, 3, 4 or 5; in formula III; the dotted line represents one optional double bond or two optional non-cumulated double bonds; one of a, b, and c is N (if the dotted line attached thereto represents a double bond), N+O-(if the dotted line attached thereto represents a double bond), N-R m or N-CO-R n , d is CH (if the dotted line attached thereto represents a double bond) or CH 2 , and each of the other two may be the same or different and each represents CH 2 or CH (if the dotted line attached thereto represents a double bond); R m represents H, alkyl, acyl, benzyl or substituted benzyl; and R n represents phenyl, substituted phenyl, alkoxy, phenoxy, substituted phenoxy, phenylalkoxy, or substituted phenylalkoxy; in formula VII; one of J and L is CHR q and the other is CR r R s or, when represents a double bond between J and L, and of J and L is CR q and the other is CR r ; R q represents H, COOR t , or alkyl; R r and R s may be the same or different and each is selected from H, alkyl, acyl, --COOR e , O(C)R e , --CN, phenylsulfonyl, substituted phenylsulfonyl, alkylsulfonyl or nitro; or R q and R r together with the carbon atoms to which they are attached represent a carbocyclic ring having from 5 to 8 carbon atoms optionally containing one carbon-carbon double bond or represent a heterocyclic ring selected from ##STR290## R e is as defined above; and R t represents H, alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl.
Claim 2
Dependent Claim
712 words
A compound having the structural formula I ##STR287## or a pharmaceutically acceptable salt or solvate thereof, wherein: in formula I: the dotted lines ( ) represent optional double bonds; W is ##STR288## T and V may be the same or different and each represents H, OH, alkyl, alkoxy, phenyl or substituted phenyl; in addition, T may also be F, Cl, or Br; X and M may be the same or different and each independently represents -CH(R a )- or -NA- when the dotted line attached thereto does not represent a double bond; or X and M each independently represents ═CH-- or ═N-- when the dotted line attached thereto represents a double bond; or when M is N and the dotted lines in ring t both represent double bonds, X and T together with the carbon atom of the ring t therebetween may also represent a group ##STR289## wherein X is a carbon atom and Q 0-3 represents zero, 1, 2 or 3 Q substituents as defined below; each A is independently selected from H, alkyl, CH 2 CH 2 OH, COR b , COOR e , SO 2 R b or (CH 2 ) s R c ; Z is O, S, N-R e or N(OR i ); B is alkenyl, NH 2 , COOR e , O(CO)R e , or an aryl group selected from phenyl, naphthyl, indenyl, indanyl, phenanthridinyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-triazinyl, furanyl, thienyl, benzofuranyl, indolyl, imidazolyl, pyrazolyl, triazolyl, or thiazolyl, any of which aryl groups may be substituted with up to three of any of the following substituents, Q: halogen, hydroxy, nitro, alkyl, CH 2 OH, trifluoromethyl, cyano, N(R f ) 2 , cycloalkyl, alkoxy, alkenyloxy, alkynyloxy, S(O) r R e , NHSO 2 R e , NHSO 2 CF 3 , NHCOCF 3 , SO 2 NH 2 , SO 2 NHR e , SO 2 N(R e ) 2 , COR h , O-D-COR h , or NHCOR d ; R a is H, OH, alkyl, phenyl, substituted phenyl, phenylalkyl or substituted phenylalkyl; R b is H, alkyl, phenyl, substituted phenyl, or N(R e ) 2 ; R c represents carboxyl or N(R i ) 2 ; R d represents H, alkyl, alkoxy, COR j or NHR k ; each R e independently represents alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl; each R f independently represents H or alkyl; R h represents OH, NH 2 or OR e ; each R i independently represents H or alkyl; R j represents OH or alkoxy; R k represents H or alkyl; D represents alkylene; r is 0, 1 or 2; and s is 1, 2, 3, 4 or 5; in formula III; the dotted line represents one optional double bond or two optional non-cumulated double bonds; one of a, b, and c is N (if the dotted line attached thereto represents a double bond), N+O-(if the dotted line attached thereto represents a double bond), N-R m or N-CO-R n , d is CH (if the dotted line attached thereto represents a double bond) or CH 2 , and each of the other two may be the same or different and each represents CH 2 or CH (if the dotted line attached thereto represents a double bond); R m represents H, alkyl, acyl, benzyl or substituted benzyl; and R n represents phenyl, substituted phenyl, alkoxy, phenoxy, substituted phenoxy, phenylalkoxy, or substituted phenylalkoxy; in formula VII; one of J and L is CHR q and the other is CR r R s or, when represents a double bond between J and L, and of J and L is CR q and the other is CR r ; R q represents H, COOR t , or alkyl; R r and R s may be the same or different and each is selected from H, alkyl, acyl, --COOR e , O(C)R e , --CN, phenylsulfonyl, substituted phenylsulfonyl, alkylsulfonyl or nitro; or R q and R r together with the carbon atoms to which they are attached represent a carbocyclic ring having from 5 to 8 carbon atoms optionally containing one carbon-carbon double bond or represent a heterocyclic ring selected from ##STR290## R e is as defined above; and R t represents H, alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl.
Claim 3
Dependent Claim
20 words
A compound according to claim 1, wherein the dotted lines in ring t represent double bonds and M represents N.
Claim 4
Dependent Claim
14 words
A compound according to claim 2, wherein T is H and Z is O.
Claim 5
Dependent Claim
14 words
A compound according to claim 3, wherein X is CH and V is H.
Claim 6
Dependent Claim
13 words
A compound according to claim 4, wherein B represents phenyl or substituted phenyl.
Claim 7
Dependent Claim
14 words
A compound according to claim 5, wherein ring W is represented by formula III.
Claim 8
Dependent Claim
35 words
A compound according to claim 6, wherein a, c and d represent CH 2 , the dotted lines in formula III do not represent double bonds, and b represents N-R m or N--CO--R n .
Claim 9
Dependent Claim
16 words
A compound according to claim 7, wherein b is N--R m and R m is acyl.
Claim 10
Dependent Claim
14 words
A compound according to claim 8, wherein B represents 3-chlorophenyl, 3-methoxyphenyl, 3-methylthiophenyl or 3-nitrophenyl.
Claim 11
Dependent Claim
14 words
A compound according to claim 5, wherein ring W is represented by formula VII.
Claim 12
Dependent Claim
30 words
A compound according to claim 10, wherein the dotted lines does not represent a double bond and J and L together represent a ring ##STR291## wherein R t is phenyl.
Claim 13
Dependent Claim
28 words
A compound according to claim 10, wherein J and L both represent CHCOOCH 3 , and the dotted line in formula VII does not represent a double bond.
Claim 14
Dependent Claim
78 words
A compound according to claim 1 having the structural formula ##STR292## wherein the dotted lines represent optional double bonds; E represents N+O-when the dotted line attached to E represents a double bond or E represents N--R m or N--(CO)R n when the double bond represented by the dotted line attached to E is absent; Q 0-3 represents up to three Q substituents as defined in claim 1; R m and R n are as defined in claim 1.
Claim 15
Dependent Claim
35 words
A compound according to claim 1 having the name: 7-acetyl-6,8,9,10-tetrahydro-10-phenyl-pyrido[2,3-b][1,6]naphthyridin-5-(7H)-one; 7-acetyl-6,8,9,10-tetrahydro-10-(3-trifluoromethyl-phenyl)-pyrido [2,3-b][1,6]naphthyridin-5-(7H)-one; 10-(3-nitrophenyl)-6,7,8,9-tetrahydro-7-N-acetyl-pyrido[2,3-b][1,8]naphthyridin-5-(10H)-one; 10-phenyl-6,8,9,10-tetrahydropyrido[2,3-b][1,6]naphthyridin-5(7H)-one; 10-(3-chlorophenyl)-6,8,9,10-tetrahydropyrido[2,3-b][1,6]naphthyridin-5(10H)-one; 10-(3-chlorophenyl)-6,7,8,9-tetrahydro-7,7-dimethyl-pyrido[2,3-b][1,6]naphthyridinium-5(10H)-one iodide; 10-(3-chlorophenyl)-6,7,8,9-tetrahydro-7-N-benzyl-pyrido[2,3-b][1,6]naphthyridin-5(10H)-one; 10-(3-chlorophenyl)pyrido[2,3-b][1,6]naphthyridin-5(10H)-one; 8-(3-chlorophenyl)-6,7,13b,13c-tetrahydro-2-phenylpyrrolo[3",4",4',5']isoxazolo[2',3',1,2]pyrido[4,3-b][1,8]naphthyridin1,3,13(2H,3aH,8H)-trione; 10-(3-chlorophenyl)-pyrido[2,3-b][1,6]naphthyridin-5(10H)-one-7-oxide; 10-(3-chlorophenyl)-8,9-dihydro-pyrido2,3-b][1,6]naphthyridin-5(10H)-one-7-oxide; 7-(3-chlorophenyl)-1,5,6,12b-tetrahydro-12-oxo-2H-isoxazolo[2',3':1,2]pyrido[4,3-b][1,8]naphthyridine-1,2-cis-dicarboxylic acid, dimethyl ester; 7-(3-chlorophenyl)-1,5,6,12b-tetrahydro-12-oxo-2H-isoxazolo[2',3':1,2]pyrido[4,3-b][1,8]naphthyridine-1,2-trans-dicarboxylic acid, dimethyl ester; 10-(3-chlorophenyl)-6,7,8,9-tetrahydro-7,7-dimethylpyrido[4,3-b][1,8]naphthyridinium-5(10H)-one iodide; 5-(3-chlorophenyl)-1,3,4,5-tetrahydropyrido-1-(phenyl-methyl)-[2,3b][1,5]naphthyridin-10(2H)-one; or 7-acetyl-10-(3-chlorophenyl)-2-methyl-6,8,9,10-tetrahydropyrido[2,3-b][1,6]naphthyridin-5(7H)-one.
Claim 16
Dependent Claim
1 words
7-acetyl-10-(3-chlorophenyl)-6,8,9,10-tetrahydropyrido[2,3b][1,6]-naphthyridin-5-(7H)-one.
Claim 17
Dependent Claim
1 words
7-acetyl-10-(3-chlorophenyl)-6,8,9,10-tetrahydropyrido[2,3b][1,6]-naphthyridin-5-(7H)-one.
Claim 18
Dependent Claim
22 words
A pharmaceutical composition which comprises a compound having structural formula I defined in claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 19
Dependent Claim
40 words
A method for treating allergic reactions, inflammation, peptic ulcers, hypertension or hyperproliferative skin disease in a mammal which comprises administering to said mammal an effective amount for such purpose of a compound of formula I as defined in claim 1.
Claim 20
Dependent Claim
31 words
A method for suppressing the immune response in a mammal which comprises administering to said mammal an immunosuppressive effective amount of a compound of formula I as defined in claim 1.
Claim 21
Dependent Claim
14 words
A method according to claim 7, wherein the compound of formula I is 7-acetyl-10-(3-chlorophenyl)-6,8,9,10-tetrahydropyrido[2,3-b][1,6]naphthyridin-5(7H)-one.
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