Substituted 1,8-naphthyridinones, useful as anti-allergic agents

Claim 1

A compound represented by the formulae ##STR6## wherein n is 1 or 2; R 1 and R 2 may combined to form a bond, or R 1 is hydrogen and R 2 is OR, halogen or NR 3 R 4 ; R is hydrogen, ##STR7## R 3 and R 4 are independently hydrogen or alkyl having from 1 to 6 carbon atoms, or R 3 and R 4 may be combined with the nitrogen to which they are attached to form a pyrrolidino, piperidino, morpholino or piperazino ring; R 5 is hydrogen or ##STR8## R 6 is alkyl having from 1 to 9 carbon atoms, alkenyl having from 2 to 7 carbon atoms, alkynyl having from 2 to 7 carbon atoms, phenyl, substituted phenyl wherein the substituents are as defined for X, or benzyl; R 7 and R 8 are independently hydrogen, lower alkyl having from 1 to 6 carbon atoms, or hydroxyalkyl having from 1 to 6 carbon atoms; X is hydrogen, hydroxy, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms, nitro, halogen, alkyl-S(O) m having from 1 to 6 carbon atoms, and wherein m is zero, 1 or 2, or trifluoromethyl; and Y is CH or N; and the acid addition salts thereof.