Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives

Claim 1

A compound having the structural formula I ##STR287## or a pharmaceutically acceptable salt or solvate thereof, wherein: in formula I: the dotted lines ( ) represent optional double bonds; W is ##STR288## T and V may be the same or different and each represents H, OH, alkyl, alkoxy, phenyl or substituted phenyl; in addition, T may also be F, Cl, or Br; X and M may be the same or different and each independently represents -CH(R a )- or -NA- when the dotted line attached thereto does not represent a double bond; or X and M each independently represents ═CH-- or ═N-- when the dotted line attached thereto represents a double bond; or when M is N and the dotted lines in ring t both represent double bonds, X and T together with the carbon atom of the ring t therebetween may also represent a group ##STR289## wherein X is a carbon atom and Q 0-3 represents zero, 1, 2 or 3 Q substituents as defined below; each A is independently selected from H, alkyl, CH 2 CH 2 OH, COR b , COOR e , SO 2 R b or (CH 2 ) s R c ; Z is O, S, N-R e or N(OR i ); B is alkenyl, NH 2 , COOR e , O(CO)R e , or an aryl group selected from phenyl, naphthyl, indenyl, indanyl, phenanthridinyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-triazinyl, furanyl, thienyl, benzofuranyl, indolyl, imidazolyl, pyrazolyl, triazolyl, or thiazolyl, any of which aryl groups may be substituted with up to three of any of the following substituents, Q: halogen, hydroxy, nitro, alkyl, CH 2 OH, trifluoromethyl, cyano, N(R f ) 2 , cycloalkyl, alkoxy, alkenyloxy, alkynyloxy, S(O) r R e , NHSO 2 R e , NHSO 2 CF 3 , NHCOCF 3 , SO 2 NH 2 , SO 2 NHR e , SO 2 N(R e ) 2 , COR h , O-D-COR h , or NHCOR d ; R a is H, OH, alkyl, phenyl, substituted phenyl, phenylalkyl or substituted phenylalkyl; R b is H, alkyl, phenyl, substituted phenyl, or N(R e ) 2 ; R c represents carboxyl or N(R i ) 2 ; R d represents H, alkyl, alkoxy, COR j or NHR k ; each R e independently represents alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl; each R f independently represents H or alkyl; R h represents OH, NH 2 or OR e ; each R i independently represents H or alkyl; R j represents OH or alkoxy; R k represents H or alkyl; D represents alkylene; r is 0, 1 or 2; and s is 1, 2, 3, 4 or 5; in formula III; the dotted line represents one optional double bond or two optional non-cumulated double bonds; one of a, b, and c is N (if the dotted line attached thereto represents a double bond), N+O-(if the dotted line attached thereto represents a double bond), N-R m or N-CO-R n , d is CH (if the dotted line attached thereto represents a double bond) or CH 2 , and each of the other two may be the same or different and each represents CH 2 or CH (if the dotted line attached thereto represents a double bond); R m represents H, alkyl, acyl, benzyl or substituted benzyl; and R n represents phenyl, substituted phenyl, alkoxy, phenoxy, substituted phenoxy, phenylalkoxy, or substituted phenylalkoxy; in formula VII; one of J and L is CHR q and the other is CR r R s or, when represents a double bond between J and L, and of J and L is CR q and the other is CR r ; R q represents H, COOR t , or alkyl; R r and R s may be the same or different and each is selected from H, alkyl, acyl, --COOR e , O(C)R e , --CN, phenylsulfonyl, substituted phenylsulfonyl, alkylsulfonyl or nitro; or R q and R r together with the carbon atoms to which they are attached represent a carbocyclic ring having from 5 to 8 carbon atoms optionally containing one carbon-carbon double bond or represent a heterocyclic ring selected from ##STR290## R e is as defined above; and R t represents H, alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl.