Patent US4988682A successfully refreshed from Google Patents.
US4988682A
Expired / Lapsed
US
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Myo-inositol analogs and method for their use
Assignee: University of Pittsburgh
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Filing: 1989-02-03
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Granted: 1991-01-29
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Expires: 2009-02-03
Abstract
Abstract The present invention relates to a method for inhibiting the phosphatidylinositol cycle in a cell by contacting the cell with certain myo-inositol analogs. Such myo-inositol analogs can also be utilized to treat phosphatidylinositol cycle-dependent conditions. The present invention also provides novel myo-inositol analogs.
Inventors
- 👤 Alan P. Kozikowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:52
CPC Classifications
C; C07; C07C; C07C323/00; C07C323/10; C07C323/17; A; A61; A61K; A61K31/00; A61K31/045; A61K31/047; C07C211/00; C07C211/33; C07C211/34; C07C211/37; C07C247/00; C07C247/14; C07C255/00; C07C255/45; C07C255/46; C07C35/00; C07C35/02; C07C35/08; C07C35/14; C07C35/16; C07C35/48; C07C2601/00; C07C2601/12; C07C2601/14
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
250 words
A compound represented by the general formula II: ##STR17## wherein: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is each independently selected from the group consisting of OH, F, N 3 , NH 2 , SH, SeH, Cl Br, I and CN; with the proviso: (i) four or five of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are OH; (ii) if one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is N 3 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is selected from the group consisting of F, NH 2 , SH, SeH, Cl, Br, I and CN; (iii) if one of said R 1 , R 1 2, R 3 , R 4 , R 5 and R 6 is NH 2 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is selected from the group consisting of F, N 3 , SH, SeH, Cl, Br, I and CN; and (iv) if said R 4 , R 5 or R 6 is F, Cl, Br or I then four of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are OH.
Claim 2
Dependent Claim
250 words
A compound represented by the general formula II: ##STR17## wherein: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is each independently selected from the group consisting of OH, F, N 3 , NH 2 , SH, SeH, Cl Br, I and CN; with the proviso: (i) four or five of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are OH; (ii) if one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is N 3 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is selected from the group consisting of F, NH 2 , SH, SeH, Cl, Br, I and CN; (iii) if one of said R 1 , R 1 2, R 3 , R 4 , R 5 and R 6 is NH 2 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is selected from the group consisting of F, N 3 , SH, SeH, Cl, Br, I and CN; and (iv) if said R 4 , R 5 or R 6 is F, Cl, Br or I then four of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are OH.
Claim 3
Dependent Claim
29 words
A compound according to claim 1 wherein five of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are OH.
Claim 4
Dependent Claim
30 words
The compound of claim 1 wherein one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is F or SH.
Claim 5
Dependent Claim
29 words
The compound method of claim 3 wherein one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is F.
Claim 6
Dependent Claim
23 words
The compound of claim 1 wherein R 1 is selected from the group consisting of F, SH, SeH, Cl, Br, I and CN.
Claim 7
Dependent Claim
12 words
The compound of claim 5 wherein R 1 is F or SH.
Claim 8
Dependent Claim
10 words
The compound of claim 6 wherein R 1 is F.
Claim 9
Dependent Claim
23 words
The compound of claim 1 wherein R 3 is selected from the group consisting of F, SH, SeH, Cl, Br, I and CN.
Claim 10
Dependent Claim
12 words
The compound of claim 8 wherein R 3 is F or SH.
Claim 11
Dependent Claim
10 words
The compound of claim 9 wherein R 3 is F.
Claim 12
Dependent Claim
28 words
The compound of claim 1 wherein four of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are OH.
Claim 13
Dependent Claim
39 words
The compound of claim 11 wherein two of said R 1 , R 4 and R 5 are independently selected from the group consisting of F, N 3 , NH 2 , SH, SeH, Cl, Br, I and CN.
Claim 14
Dependent Claim
34 words
The compound of claim 12 wherein said R 4 and R 5 are independently selected from the group consisting of F, N 3 , NH 2 , SH, SeH, Cl, Br I and CN.
Claim 15
Dependent Claim
52 words
The compound of claim 11 wherein two of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are selected from the group consisting of F and SH; F and NH 2 ; NH 2 and SH; SH and SH; and F and F.
Claim 16
Dependent Claim
30 words
The compound of claim 14 wherein two of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are F and F.
Claim 17
Dependent Claim
279 words
A pharmaceutical composition comprising a therapeutically effective amount for inhibiting the phosphatidylinositol cycle in a manual of a compound represented by the general formula III: ##STR18## wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is each independently selected from the group consisting of OH, F, N 3 , NH 2 , SH, SeH, Cl, Br, I and CN; with the proviso: (i) four or five of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are OH; (ii) if one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is N 3 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is selected from the group consisting of F, NH 2 , SH, SeH, Cl, Br, I and CN; (iii) if one of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is NH 2 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is selected from the group consisting of F, N 3 , SH, SeH, Cl, Br, I and CN; and (iv) if said R 4 , R 5 , and R 6 is F, Cl, Br, or I then four of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are OH, and a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
279 words
A pharmaceutical composition comprising a therapeutically effective amount for inhibiting the phosphatidylinositol cycle in a manual of a compound represented by the general formula III: ##STR18## wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is each independently selected from the group consisting of OH, F, N 3 , NH 2 , SH, SeH, Cl, Br, I and CN; with the proviso: (i) four or five of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are OH; (ii) if one of said R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is N 3 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is selected from the group consisting of F, NH 2 , SH, SeH, Cl, Br, I and CN; (iii) if one of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is NH 2 , then one of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is selected from the group consisting of F, N 3 , SH, SeH, Cl, Br, I and CN; and (iv) if said R 4 , R 5 , and R 6 is F, Cl, Br, or I then four of said R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are OH, and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-01-28 | 1994-07-30 | 1995-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-28 | 1998-07-30 | 1999-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-28 | 2002-07-30 | 2003-01-29 | $7700.00 | Window Closed / Lapsed |