Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents

Claim 1

A compound of formula: ##STR23## or a pharmaceutically acceptable acid, ester, ether or carbonate thereof, wherein: L is (a) hydrogen; (b) R 1 ; where R 1 is (1) straight or branched-chain alkyl having from 1 to 20 carbon atoms especially C 1-6 alkyl; (2) aryl having from 6 to 10 carbon atoms; (3) cycloalkyl having from 3 to 8 carbon atoms; (4) alkenyl having from 2 to 20 carbon atoms especially C 8-20 alkenyl; (5) cycloalkenyl having from 5 to 8 carbon atoms; (6) aralkyl, alkaryl, aralkenyl, alkenylaryl wherein alkyl, aryl, and alkenyl are as previously defined; The above groups (1) to (6) are unsubstituted or substituted by hydroxy; alkoxy; halo; cyano; carboxy; amino; substituted amino; carbamoyl; sulfonyl; sulfinyl; thio; alkylthio; or nitro; (c) ##STR24## where R 2 and R 3 independently are: ##STR25## n is an integer from 1 to 4; or (d) ##STR26## wherein R 2 , R 3 , and n are as defined previously; R is (a) hydrogen; (b) loweralkyl; (c) cycloalkyl having from 3 to 8 carbon atoms; or (d) aralkyl; Y is oxygen or methylene; and A is a radical of (a) myo-inositol or a configuration isomer thereof; (b) branched chain myo-inositol; (c) 2-,4 or 5-positional isomer of myo-inositol; (d) inositol substituted with amino; azido; deoxy; halo; or (e) branched-chain inositol of the structural formula (e); ##STR27## where R 4 is C 1-6 alkyl or substituted C 1-6 alkyl; (f) phosphoryl inositols having one or more of its hydroxy groups coupled with another ##STR28## group; or (g) epimeric myo-inositol.