US4129650A
Expired / Lapsed
US
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Novel phospholipid derivatives of prostaglandins and process of their preparation
Assignee: A Natterman und Cie GmbH
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Filing: 1977-06-28
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Granted: 1978-12-12
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Expires: 1997-06-28
Abstract
Abstract A compound of the formula ##STR1## (wherein R 1 and R 2 are each H or a fatty-acid residue, and R 3 is ##STR2## and PG is a prostaglandin radical or optical isomer thereof) is found to have a substantially increased duration of effect, compared with the corresponding prostaglandin per se, and also a strong organ specificity.
Inventors
- 👤 Hans Betzing
- 👤 Dac Lekim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:56
CPC Classifications
C; C07; C07C; C07C405/00; A; A61; A61P; A61P43/00; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/117
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
74 words
An ester or amide derivative of natural prostaglandin and having the formula ##STR13## wherein R 1 and R 2 are each hydrogen or a fatty-acid radical with the proviso that at least one of R 1 or R 2 is a fatty-acid radical, and R 3 is one of the following groups ##STR14## wherein PG is a prostagladin radical or its optical isomer, said PG being attached to the phospholipid through the carboxyl moiety.
Claim 2
Dependent Claim
74 words
An ester or amide derivative of natural prostaglandin and having the formula ##STR13## wherein R 1 and R 2 are each hydrogen or a fatty-acid radical with the proviso that at least one of R 1 or R 2 is a fatty-acid radical, and R 3 is one of the following groups ##STR14## wherein PG is a prostagladin radical or its optical isomer, said PG being attached to the phospholipid through the carboxyl moiety.
Claim 3
Dependent Claim
22 words
A process of preparing a compound of claim 1, wherein the phospholipid is reacted with a prostaglandin in the presence of dicyclohexylcarbodiimide.
Claim 4
Dependent Claim
27 words
A process as in claim 2, wherein said prostaglandin is protected by a protective group, which is split off under mild conditions after the reaction is completed.
Claim 5
Dependent Claim
21 words
A medicament composition comprising a pharmaceutical excipient and a compound of claim 1 in an amount sufficient to lower blood pressure.
Claim 6
Dependent Claim
11 words
A compound in accordance with claim 1 of the formula ##STR15##
Claim 7
Dependent Claim
17 words
A compound in accordance with claim 1 wherein R 1 and R 2 are both fatty acids.
References Cited (Backward Citations)
US3632627A
Cited
US3746728A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-11 | 1982-06-12 | 1982-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-11 | 1986-06-12 | 1986-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-11 | 1990-06-12 | 1990-12-12 | $7700.00 | Window Closed / Lapsed |