Patent US4972147A successfully refreshed from Google Patents.
US4972147A
Expired / Lapsed
US
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Magnetic resonance method for obtaining selected spectra
Assignee: US Philips Corp
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Filing: 1989-06-05
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Granted: 1990-11-20
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Expires: 2009-06-05
Abstract
Abstract The method includes a critical time shift of a refocusing pulse between two (90°) excitation pulses which produce multiple quantum coherence signals and which are followed by a (90°) read pulse (using a critical timing a refocusing pulse serving the same purpose can also be applied between the second excitation pulse and the read pulse). With respect to the center of the time path between the excitation pulses or between the excitation pulse and the read pulse the time shift is chosen to be such that give resonances do not occur positively or negatively in the spectrum whereas other resonances do occur therein (i.e. at substantially maximum strength). The MRI method can be combined with the use of spatially selective gradients in order to obtain localized spectra or images.
Inventors
- 👤 Johannes J. Van Vaals
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:17
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/4833
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
152 words
A method of determining a nuclear magnetization distribution of one of predetermined first and second substances in an object, which first and second substances have substantially overlapping nuclear magnetic distribution spectra comprising irradiating the object with a sequence of three rf pulses and a 180 degree rf pulse between two consecutive ones of said three rf pulses, said three rf pulses being selected and positioned in time to excite weakly coupled nuclear spins in said first substance and in said second substance, and said 180 degree rf pulse being at an instant shifted in time from an instant halfway between said two consecutive ones of said three rf pulses, the instant of said 180 rf pulse being chosen so that the amplitude of a multiple quantum coherence is zero for the first substance and is substantially maximum for the second substance; and sampling a nuclear magnetic resonance signal generated after said sequence.
Claim 2
Independent Claim
152 words
A method of determining a nuclear magnetization distribution of one of predetermined first and second substances in an object, which first and second substances have substantially overlapping nuclear magnetic distribution spectra comprising irradiating the object with a sequence of three rf pulses and a 180 degree rf pulse between two consecutive ones of said three rf pulses, said three rf pulses being selected and positioned in time to excite weakly coupled nuclear spins in said first substance and in said second substance, and said 180 degree rf pulse being at an instant shifted in time from an instant halfway between said two consecutive ones of said three rf pulses, the instant of said 180 rf pulse being chosen so that the amplitude of a multiple quantum coherence is zero for the first substance and is substantially maximum for the second substance; and sampling a nuclear magnetic resonance signal generated after said sequence.
Claim 3
Dependent Claim
57 words
A method as claimed in claim 1, wherein said 180 degree rf pulse is a first 180 degree rf pulse and is between a first and a second of said three rf pulses and wherein said sequence further comprises a second 180 degree rf pulse halfway between said second and a third of said three rf pulses.
Claim 4
Dependent Claim
57 words
A method as claimed in claim 1, wherein said 180 degree rf pulse is a first 180 degree rf pulse and is between a second and a third of said three rf pulses and wherein said sequence further comprises a second 180 degree rf pulse halfway between a first and a second of said three rf pulses.
Claim 5
Dependent Claim
55 words
A method as claimed in claim 1, wherein said sequence further comprises a slice-selective 180 degree rf echo pulse after the expiration of a waiting period after a third of said three rf pulses, said waiting period being equal to half a waiting period between a first and a second of said three rf pulses.
Claim 6
Dependent Claim
55 words
A method as claimed in claim 2, wherein said sequence further comprises a slice-selective 180 degree rf echo pulse after the expiration of a waiting period after the third of said three rf pulses, said waiting period being equal to half a waiting period between the first and the second of said three rf pulses.
Claim 7
Dependent Claim
55 words
A method as claimed in claim 3, wherein said sequence further comprises a slice-selective 180 degree rf echo pulse after the expiration of a waiting period after the third of said three rf pulses, said waiting period being equal to half a waiting period between the first and the second of said three rf pulses.
Claim 8
Dependent Claim
15 words
A method as claimed in claim 1, wherein said 180 degree rf pulse is slice-selective.
Claim 9
Dependent Claim
22 words
A method as claimed in claim 2, wherein said first and second 180 degree rf pulses are slice-selective for the same slice.
Claim 10
Dependent Claim
22 words
A method as claimed in claim 3, wherein said first and second 180 degree rf pulses are slice-selective for the same slice.
Claim 11
Dependent Claim
27 words
A method as claimed in claim 4, wherein said 180 degree rf pulse is slice-selective for the same slice as said slice-selective 180 degree rf echo pulse.
Claim 12
Dependent Claim
30 words
A method as claimed in claim 5, wherein said first and second 180 degree rf pulses are slice-selective for the same slice as said slice-selective 180 degree rf echo pulse.
Claim 13
Dependent Claim
30 words
A method as claimed in claim 6, wherein said first and second 180 degree rf pulses are slice-selective for the same slice as said slice-selective 180 degree rf echo pulse.
Claim 14
Dependent Claim
28 words
A method as claimed in claim 1, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 15
Dependent Claim
28 words
A method as claimed in claim 2, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 16
Dependent Claim
28 words
A method as claimed in claim 3, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 17
Dependent Claim
28 words
A method as claimed in claim 4, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 18
Dependent Claim
28 words
A method as claimed in claim 5, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 19
Dependent Claim
28 words
A method as claimed in claim 6, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 20
Dependent Claim
28 words
A method as claimed in claim 7, wherein said three rf pulses are respectively slice-selective in three orthogonal directions for the selection of a sub-volume in the object.
Claim 21
Dependent Claim
25 words
A method as claimed in claim 1, wherein said 180 degree rf pulse is between a first and a second of said three rf pulses.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-19 | 1994-05-21 | 1994-11-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-19 | 1998-05-21 | 1998-11-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-19 | 2002-05-21 | 2002-11-20 | $7700.00 | Window Closed / Lapsed |