US4789832A
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Three-dimensional NMR spectroscopy
Assignee: Jeol Ltd
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Filing: 1988-01-12
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Granted: 1988-12-06
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Expires: 2008-01-12
Abstract
Abstract A three-dimensional NMR spectroscopy capable of obtaining a plurality of two-dimensional NMR spectra by a single series of measurements. In this spectroscopy, a pulse sequence consisting of three 90°-pulses and a 180°-pulse is utilized. The three 90°-pulses are produced at intervals. The interval between the second and the third 90°-pulses is set to τ m . The 180°-pulse is produced at the middle of the interval τ m . In a first embodiment of the invention, the interval t 1 between the first and the second 90°-pulses and the RF phases φ of the first and second 90°-pulses and of the 180°-pulse are taken as variables. The free induction decay signals produced after the lapse of a period of t 2 subsequent to the third 90°-pulse are collected to create data S (t 1 , t 2 , φ). In a second embodiment of the invention, the intervals t 1 and τ m are taken as variables, τ m being rewritten as t 3 . The free induction decay signals produced during the period t 2 are collected to create data S (t 1 , t 2 , t 3 ). The data of either kind is subjected to complex Fourier transformation with respect to t 1 and t 2 and then to cosine Fourier transformation with respect to φ or t 3 to obtain a three-dimensional NMR spectrum S (ω 1 , ω 2 , p) or S (ω 1 , ω 2 , J) made up of plural 2D NMR spectra.
Inventors
- 👤 Kuniaki Nagayama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:20
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/46; G01R33/4633
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
261 words
A three-dimensional nuclear magnetic resonance spectroscopy comprising the steps of: (a) applying a first 90°-pulse to a sample containing gyromagnetic resonators after the lapse of a given preparation period; (b) applying a second 90°-pulse to the sample after the lapse of an evolution period of t 1 that follows the application of the first 90°-pulse; (c) applying a 180°-pulse to the sample at the middle of a mixing period of T m that follows the application of the second 90°-pulse and applying a third 90°-pulse to the sample after the mixing period of T m ; (d) detecting the free induction decay signal emanating from the resonators during a detection period of t 2 that follows the application of the third 90°-pulse and storing the obtained data in a memory; (e) carrying out the steps (a)-(d) while systematically varying the length t 1 of the evolution period and a second pulse train parameter X, obtaining the sum S (t 1 , t 2 , X) of the resulting free induction decay signals, and storing the data in the memory; (f) taking the complex Fourier transform of the data S (t 1 , t 2 , X) with respect to t 2 ; (g) taking the complex Fourier transform of the transformed data S (t 1 , ω 2 , X) with respect to t 1 ; and (h) taking the cosine Fourier transform of the transformed data S (ω 1 , ω 2 , X) with respect to X to obtain a spectrum S (ω 1 , ω 2 , Y).
Claim 2
Dependent Claim
261 words
A three-dimensional nuclear magnetic resonance spectroscopy comprising the steps of: (a) applying a first 90°-pulse to a sample containing gyromagnetic resonators after the lapse of a given preparation period; (b) applying a second 90°-pulse to the sample after the lapse of an evolution period of t 1 that follows the application of the first 90°-pulse; (c) applying a 180°-pulse to the sample at the middle of a mixing period of T m that follows the application of the second 90°-pulse and applying a third 90°-pulse to the sample after the mixing period of T m ; (d) detecting the free induction decay signal emanating from the resonators during a detection period of t 2 that follows the application of the third 90°-pulse and storing the obtained data in a memory; (e) carrying out the steps (a)-(d) while systematically varying the length t 1 of the evolution period and a second pulse train parameter X, obtaining the sum S (t 1 , t 2 , X) of the resulting free induction decay signals, and storing the data in the memory; (f) taking the complex Fourier transform of the data S (t 1 , t 2 , X) with respect to t 2 ; (g) taking the complex Fourier transform of the transformed data S (t 1 , ω 2 , X) with respect to t 1 ; and (h) taking the cosine Fourier transform of the transformed data S (ω 1 , ω 2 , X) with respect to X to obtain a spectrum S (ω 1 , ω 2 , Y).
Claim 3
Dependent Claim
269 words
A three-dimensional nuclear magnetic resonance spectroscopy comprising the steps of: (a) applying a first 90°-pulse to a sample containing gyromagnetic resonators after the lapse of a given preparation period; (b) applying a second 90°-pulse to the sample after the lapse of an evolution period of t 1 that follows the application of the first 90°-pulse; (c) applying a 180°-pulse to the sample at the middle of a mixing period of τ m that follows the application of the second 90°-pulse and applying a third 90°-pulse to the sample after the mixing period of τ m ; (d) detecting the free induction decay signal emanating from the resonators during a detection period of t 2 that follows the application of the third 90°-pulse and storing the obtained data in a memory; (e) carrying out the steps (a)-(d) while systematically varying the length t 1 of the evolution period and the RF phases φ of the first 90°-pulse, the second 90°-pulse, and the 180°-pulse, obtaining the sum S (t 1 , t 2 , φ) of the resulting free induction decay signals, and storing the data in the memory; (f) taking the complex Fourier transform of the data S (t 1 , t 2 , φ) with respect to t 2 ; (g) taking the complex Fourier transform of the transformed data S (t 1 , ω 2 , φ) with respect to t 1 ; and (h) taking the cosine Fourier transform of the transformed data S (ω 1 , ω 2 , φ) with respect to φ to obtain a spectrum S (ω 1 , ω 2 , p).
Claim 4
Dependent Claim
269 words
A three-dimensional nuclear magnetic resonance spectroscopy comprising the steps of: (a) applying a first 90°-pulse to a sample containing gyromagnetic resonators after the lapse of a given preparation period; (b) applying a second 90°-pulse to the sample after the lapse of an evolution period of t 1 that follows the application of the first 90°-pulse; (c) applying a 180°-pulse to the sample at the middle of a mixing period of τ m that follows the application of the second 90°-pulse and applying a third 90°-pulse to the sample after the mixing period of τ m ; (d) detecting the free induction decay signal emanating from the resonators during a detection period of t 2 that follows the application of the third 90°-pulse and storing the obtained data in a memory; (e) carrying out the steps (a)-(d) while systematically varying the length t 1 of the evolution period and the RF phases φ of the first 90°-pulse, the second 90°-pulse, and the 180°-pulse, obtaining the sum S (t 1 , t 2 , φ) of the resulting free induction decay signals, and storing the data in the memory; (f) taking the complex Fourier transform of the data S (t 1 , t 2 , φ) with respect to t 2 ; (g) taking the complex Fourier transform of the transformed data S (t 1 , ω 2 , φ) with respect to t 1 ; and (h) taking the cosine Fourier transform of the transformed data S (ω 1 , ω 2 , φ) with respect to φ to obtain a spectrum S (ω 1 , ω 2 , p).
Claim 5
Dependent Claim
265 words
A three-dimensional nuclear magnetic resonance spectroscopy comprising the steps of: (a) applying a first 90°-pulse to a sample containing gyromagnetic resonators after the lapse of a given preparation period; (b) applying a second 90°-pulse to the sample after the lapse of an evolution period of t 1 that follows the application of the first 90°-pulse; (c) applying a 180°-pulse to the sample at the middle of a mixing period of t 3 after the application of the second 90°-pulse and applying a third 90°-pulse to the sample after the mixing period of t 3 ; (d) detecting the free induction decay signal emanating from the resonators during a detection period of t 2 that follows the application of the third 90°-pulse and storing the obtained data in a memory; (e) carrying out the steps (a)-(d) while systematically varying the length t 1 of the evolution period and the length t 3 of the mixing period and obtaining the sum S (t 1 , t 2 , t 3 ) of the resulting free induction decay signals; (f) taking the complex Fourier transform of the data S (t 1 , t 2 , t 3 ) with respect to t 2 ; (g) taking the complex Fourier transform of the transformed data S (t 1 , ω 2 , t 3 ) with respect to t 1 ; and (h) taking the cosine Fourier transform of the transformed data S (ω 1 , ω 2 , t 3 ) with respect to t 3 to obtain a spectrum S (ω 1 , ω 2 , J).
Claim 6
Dependent Claim
265 words
A three-dimensional nuclear magnetic resonance spectroscopy comprising the steps of: (a) applying a first 90°-pulse to a sample containing gyromagnetic resonators after the lapse of a given preparation period; (b) applying a second 90°-pulse to the sample after the lapse of an evolution period of t 1 that follows the application of the first 90°-pulse; (c) applying a 180°-pulse to the sample at the middle of a mixing period of t 3 after the application of the second 90°-pulse and applying a third 90°-pulse to the sample after the mixing period of t 3 ; (d) detecting the free induction decay signal emanating from the resonators during a detection period of t 2 that follows the application of the third 90°-pulse and storing the obtained data in a memory; (e) carrying out the steps (a)-(d) while systematically varying the length t 1 of the evolution period and the length t 3 of the mixing period and obtaining the sum S (t 1 , t 2 , t 3 ) of the resulting free induction decay signals; (f) taking the complex Fourier transform of the data S (t 1 , t 2 , t 3 ) with respect to t 2 ; (g) taking the complex Fourier transform of the transformed data S (t 1 , ω 2 , t 3 ) with respect to t 1 ; and (h) taking the cosine Fourier transform of the transformed data S (ω 1 , ω 2 , t 3 ) with respect to t 3 to obtain a spectrum S (ω 1 , ω 2 , J).
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-12-06 | 1992-06-06 | 1992-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-06 | 1996-06-06 | 1996-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-06 | 2000-06-06 | 2000-12-06 | $7700.00 | Window Closed / Lapsed |