Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives

Claim 1

Composition for inducing and stimulating hair growth and retarding its loss, in a cosmetically or pharmaceutically acceptable medium, said composition comprising an effective amount for inducing and stimulating hair growth and retarding its loss of at least one pyrimidine derivative corresponding to the formula: ##STR6## wherein R 1 denotes a group ##STR7## wherein R 3 and R 4 are selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 2 -C 5 alkenyl, C 1 -C 4 alkylaryl and lower cycloalkyl group, the alkyl part of which is a C 1 -C 4 alkyl radical, or R 3 and R 4 together form a heterocyclic ring with the nitrogen atom to which they are attached, this heterocyclic ring being selected from the group consisting of aziridinyl, azetidinyl, pyrrolidinyl, piperidino, hexahydroazepinyl, heptamethyleneimino, octamethyleneimino, morpholino and 4-(lower alkyl)piperazidinyl, the heterocyclic groups being unsubstituted or substituted on the carbon atoms with one to three C 1 -C 4 alkyl, hydroxyl or C 1 -C 4 alkoxy, and wherein R 2 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 2 -C 5 alkenyl, C 1 -C 4 alkoxy C 1 -C 4 alkyl cycloalkyl, C 1 -C 4 aryl, C 1 -C 4 alkylaryl, aryl C 1 -C 4 alkyl, C.sub. 1 -C 4 alkylaryl C 1 -C 4 alkyl, C 1 -C 4 alkoxyaryl C 1 -C 4 alkyl and haloaryl C 1 -C 4 alkyl, or one of its addition salts with cosmetically or pharmaceutically acceptable, acids, the pyrimidine derivative of formula (I) being present in the composition in a proportion of between 0.05 and 6% by weight relative to the total weight of the composition. and an effective amount of at least one C 1 -C 6 linear or branched alkyl nicotinic ester, the nicotinic ester being present in a proportion of between 0.05 and 1% by weight relative to the total weight of the composition.