US4966911A
Expired / Lapsed
US
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Immunoregulatory agents
Assignee: BOARD OF REGENTS OF UNIVERSITY OF WASHINGTON A PUBLIC INSTITUTION OF HIHGER EDUCATION
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Filing: 1989-02-10
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Granted: 1990-10-30
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Expires: 2009-02-10
Abstract
Abstract Specific aspects of the cellular and humoral immune systems of a mammalian host are regulated by administering to the host a compound having a reactive immunoregulatory conformation whose precise three-dimensional structure is defined herein. Sorbinil, tolrestat, WF-3681, and the other immunoregulatory agents described herein process this reactive conformation and so are therapeutically useful for inhibiting delayed-type hypersensitivity, T-cell proliferation, and B-cell antibody production, without altering the normal cellularity of the immune system or the normal metabolites of the arachidonic acid pathway.
Inventors
- 👤 John I. Clark
- 👤 Andrew G. Farr
- 👤 Stacia A. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61K31/185; A61K31/19; A61K31/195; A61K31/395; A61K31/41; A61K31/415
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
191 words
A method of regulating the immune system of a mammalian host, comprising the step of administering to the host a compound having an immunoregulatory conformation comprising an aromatic ring associated with two atoms X 1 and X 2 selected individually from among oxygen, sulfur, and nitrogen, the immunoregulatory conformation being defined as follows: 3.1 Å≦D.sub.1 ≦4.1 Å, 2.4 Å≦D.sub.2 ≦2.8 Å, 3.8 Å≦D.sub.3 ≦4.2 Å, and 35°≦α°≦60°, wherein P 1 =the plane defined by the aromatic ring, D 1 =the distance between the centers of plane P 1 and atom X 1 , D 2 =the distance between the centers of plane P 1 and atom X 2 , D 3 =the distance between the centers of atoms X 1 and X 2 , P 2 =the plane defined by atoms X 1 and X 2 and the center of plane P 1 , and α°=the angle between planes P 1 and P 2 , taken at the intersection of vectors normal to each plane, and wherein the aromatic ring is essentially planar and consists of 5 to 7 ring atoms that are cylindrically symmetrical within about 15 degrees of planar.
Claim 2
Independent Claim
191 words
A method of regulating the immune system of a mammalian host, comprising the step of administering to the host a compound having an immunoregulatory conformation comprising an aromatic ring associated with two atoms X 1 and X 2 selected individually from among oxygen, sulfur, and nitrogen, the immunoregulatory conformation being defined as follows: 3.1 Å≦D.sub.1 ≦4.1 Å, 2.4 Å≦D.sub.2 ≦2.8 Å, 3.8 Å≦D.sub.3 ≦4.2 Å, and 35°≦α°≦60°, wherein P 1 =the plane defined by the aromatic ring, D 1 =the distance between the centers of plane P 1 and atom X 1 , D 2 =the distance between the centers of plane P 1 and atom X 2 , D 3 =the distance between the centers of atoms X 1 and X 2 , P 2 =the plane defined by atoms X 1 and X 2 and the center of plane P 1 , and α°=the angle between planes P 1 and P 2 , taken at the intersection of vectors normal to each plane, and wherein the aromatic ring is essentially planar and consists of 5 to 7 ring atoms that are cylindrically symmetrical within about 15 degrees of planar.
Claim 3
Dependent Claim
17 words
The method of claim 1, wherein the compound is effective to inhibit the delayed type hypersensitivity reaction.
Claim 4
Dependent Claim
24 words
The method of claim 1, wherein the compound has the following immunoregulatory conformation: D.sub.1 ≅4.06 Å, D.sub.2 ≅2.74 Å, D.sub.3 ≅4.00 Å, and α°≅38.85°.
Claim 5
Dependent Claim
10 words
The method of claim 3, wherein the compound is sorbinil.
Claim 6
Dependent Claim
24 words
The method of claim 1, wherein the compound has the following immunoregulatory conformation: D.sub.1 ≅3.16 Å, D.sub.2 ≅2.70 Å, D.sub.3 ≅4.15 Å, and α°≅59.0°.
Claim 7
Dependent Claim
10 words
The method of claim 5, wherein the compound is tolrestat.
Claim 8
Dependent Claim
24 words
The method of claim 1, wherein the compound has the following immunoregulatory conformation: D.sub.1 ≅3.97 Å, D.sub.2 ≅2.45 Å, D.sub.3 ≅4.10 Å, and α°≅47.0°.
Claim 9
Dependent Claim
10 words
The method of claim 7 wherein the compound is WF-3681.
Claim 10
Dependent Claim
20 words
The method of claim 1, wherein said aromatic ring is cylindrically symmetrical within about 7 degrees or less of planar.
Claim 11
Dependent Claim
21 words
The method of claim 1, wherein said aromatic ring is selected from the group consisting of benzene, pyridine, furan, and thiophene.
Claim 12
Dependent Claim
20 words
The method of claim 1, wherein said aromatic ring is part of a ring complex selected from naphthalene and anthracene.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-29 | 1994-04-30 | 1994-10-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-29 | 1998-04-30 | 1998-10-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-29 | 2002-04-30 | 2002-10-30 | $7700.00 | Window Closed / Lapsed |