Patent US1807867A successfully refreshed from Google Patents.
US4147797A
Expired / Lapsed
US
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Spiro-furanohydantoin derivatives
Assignee: Pfizer Inc
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Filing: 1978-08-11
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Granted: 1979-04-03
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Expires: 1998-08-11
Abstract
Abstract {PG,1 Novel spiro-furanohydantoin derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The compounds include 2-methyl-spiro-{8 cyclohexa(b)furan-4,4{40 -imidazolidine{9 -2{40 ,5{40 -dione, 2-fluoro-spiro-{8 cyclohexa(b)furan-4,4{40 -imidazolidine{9 -2{40 ,5{40 -dione, 2-chloro-spiro-{8 cyclohexa(b)furan-4,4{40 -imidazolidine{9 -2{40 ,5{40 -dione, 2-bromo-spiro-{8 cyclohexa(b)furan-4,4{40 -imidazolidine{9 -2{40 ,5{40 -dione and spiro-{8 cyclohexa(b)furan-4,4{40 -imidazolidine{9 -2{40 ,5{40 -dione.
Inventors
- 👤 Paul R. Kelbaugh
- 👤 Reinhard Sarges
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 20:59
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/10; A; A61; A61P; A61P13/00; A61P13/02; A61P15/00; A61P25/00; A61P25/02; A61P27/00; A61P27/02; A61P27/12
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
22 words
A spiro-furanohydantoin compound of the formula ##STR3## or its pharmaceutically acceptable metal salt, wherein R is hydrogen, methyl, fluoro, chloro or bromo.
Claim 2
Dependent Claim
22 words
A spiro-furanohydantoin compound of the formula ##STR3## or its pharmaceutically acceptable metal salt, wherein R is hydrogen, methyl, fluoro, chloro or bromo.
Claim 3
Dependent Claim
34 words
A pharmaceutical composition of a command of claim 1 which comprises a pharmaceutical formulation of a pharmaceutically-acceptable carrier and a compound of claim 1 in an amount effective to prevent or alleviate diabetes-associated complications.
Claim 4
Dependent Claim
30 words
A method for the treatment of a diabetic host to prevent or alleviate diabetes-associated complications which comprises administering to the host an effective amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-02 | 1982-10-02 | 1983-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-02 | 1986-10-02 | 1987-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-02 | 1990-10-02 | 1991-04-03 | $7700.00 | Window Closed / Lapsed |