US4181729A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
Assignee: Pfizer Inc
•
Filing: 1979-03-21
•
Granted: 1980-01-01
•
Expires: 1999-03-21
Abstract
Abstract Novel phenyl or phenoxy substituted spiro-imidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include the phenyl or phenoxy substituted spiro-imidazolidine naphthalene, chroman, thiochroman sulfoxychroman, sulfonochroman dione compounds and the substituted forms thereof.
Inventors
- 👤 Reinhard Sarges
- 👤 John L. Belletire
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:23
CPC Classifications
C; C07; C07D; C07D235/00; C07D235/02; A; A61; A61P; A61P13/00; A61P13/02; A61P15/00; A61P25/00; A61P25/02; A61P27/00; A61P27/02; A61P27/12; A61P3/00; A61P3/08; A61P3/10; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D491/00; C07D491/02; C07D491/10; C07D495/00; C07D495/02; C07D495/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
64 words
A phenyl or phenoxy substituted spiroimidazolidinedione derivative selected from the group consisting of ##STR3## and the pharmaceutically acceptable metallic salts thereof, wherein: X is O, S, SO or SO 2 ; Y is H, CH 3 , CH 3 O, Ph, PhO, F, Cl or Br at the 6 or 8 position; and Ar is Ph or OPh at the 6 or 8 position.
Claim 2
Dependent Claim
64 words
A phenyl or phenoxy substituted spiroimidazolidinedione derivative selected from the group consisting of ##STR3## and the pharmaceutically acceptable metallic salts thereof, wherein: X is O, S, SO or SO 2 ; Y is H, CH 3 , CH 3 O, Ph, PhO, F, Cl or Br at the 6 or 8 position; and Ar is Ph or OPh at the 6 or 8 position.
Claim 3
Dependent Claim
21 words
The derivative of formula I of claim 1 wherein Y is H, and Ph is at the 1 or 3 position.
Claim 4
Dependent Claim
25 words
The derivative of formula II of claim 1 wherein X is O, Y is H and Ar is Ph at the 6 or 8 position.
Claim 5
Dependent Claim
23 words
The derivative of formula II of claim 1 wherein X is O, Y is H and Ar is PhO at the 6 position.
Claim 6
Dependent Claim
27 words
The derivative of formula II of claim 1 wherein X is O, Y is Cl at the 8 position and Ar is Ph at the 6 position.
Claim 7
Dependent Claim
35 words
A pharmaceutical preparation for inhibiting harmful, in vivo enzymatic reduction of aldoses or preventing or alleviating diabetes associated complications, which comprises: a pharmaceutically acceptable carrier and a therapeutic amount of a derivative of claim 1.
Claim 8
Dependent Claim
39 words
A method of treating a diabetic host to inhibit harmful, in vivo enzymatic reduction of aldoses or to prevent or alleviate diabetes associated complications, which comprises: administering to the host a therapeutic amount of a derivative of claim 1.
References Cited (Backward Citations)
US2716648A
Cited
US2872454A
Cited
DE1135915B
Cited
US3532744A
Cited
US3821383A
Cited
US4117230A
Cited
US4130714A
Cited
US4127665A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-31 | 1983-07-02 | 1984-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-31 | 1987-07-02 | 1988-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-31 | 1991-07-02 | 1992-01-01 | $7700.00 | Window Closed / Lapsed |