US4962188A
Expired / Lapsed
US
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Recombinant ricin toxin A chain conjugates
Assignee: Novartis Vaccines and Diagnostics Inc
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Filing: 1986-09-30
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Granted: 1990-10-09
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Expires: 2006-09-30
Abstract
Abstract Conjugates comprising recombinant ricin toxin A chain and a binding moiety which may be an antigen binding portion selected from the group consisting of Fab, Fab' and F(ab')2 fragments of monoclonal or polyclonal antibodies, hormones, lectins or other compounds that are recognized by cell receptors, are described and claimed.
Inventors
- 👤 Arthur E. Frankel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:38
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6835; A61K47/6851; A61K47/6869; A61K38/00; Y; Y10; Y10S; Y10S424/00; Y10S424/804; Y10S424/806; Y10S424/807; Y10S530/00; Y10S530/808; Y10S530/861; Y10S530/863; Y10S530/864
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
78 words
A conjugate comprising unglycosylated recombinant ricin toxin A chain and a murine monoclonal antibody, said conjugate being maintained in an effective cytotoxic amount in the circulation of a host animal for substantially longer times than similar conjugates made of native ricin A chain, wherein said monoclonal antibodies are selected from the gorup consisting of 2G3, 9C6, 33F8, 44B2, 44F4, 120H7, 200F9, 204F4, 219F3, -245E7, 260F9, 266B2, 280D11, 317G5, 369F10, 388D4, 421E8, 451C3, 454A12, 454C11, 650E2, -788G6, and 871E3.
Claim 2
Dependent Claim
78 words
A conjugate comprising unglycosylated recombinant ricin toxin A chain and a murine monoclonal antibody, said conjugate being maintained in an effective cytotoxic amount in the circulation of a host animal for substantially longer times than similar conjugates made of native ricin A chain, wherein said monoclonal antibodies are selected from the gorup consisting of 2G3, 9C6, 33F8, 44B2, 44F4, 120H7, 200F9, 204F4, 219F3, -245E7, 260F9, 266B2, 280D11, 317G5, 369F10, 388D4, 421E8, 451C3, 454A12, 454C11, 650E2, -788G6, and 871E3.
Claim 3
Dependent Claim
35 words
The conjugate as described in claim 1, wherein said conjugates have the property of being cleared about nine times slower from the circulation of a host animal than conjugates made of native ricin A chain.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-08 | 1994-04-09 | 1994-10-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-08 | 1998-04-09 | 1998-10-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-08 | 2002-04-09 | 2002-10-09 | $7700.00 | Window Closed / Lapsed |