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US4952408A
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Liposome-encapsulated vinca alkaloids and their use in combatting tumors
Assignee: Georgetown University
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Filing: 1988-05-23
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Granted: 1990-08-28
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Expires: 2008-05-23
Abstract
Abstract A composition made up of a liposome-encapsulated vinca alkaloid is disclosed. This composition possesses an increased antitumor activity and a substantially lower toxicity as compared to free drug.
Inventors
- 👤 Aquilur Rahman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:08
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/475; A61K9/00; A61K9/10; A61K9/127; A61P; A61P35/00; A61P35/02; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
34 words
A pharmaceutical composition, comprising a liposome-encapsulated effective amount of a vinca alkaloid in complexation with cardiolipin, said vinca alkaloid being at least one member selected from the group consisting of vincristine, vinblastine and vindesine.
Claim 2
Dependent Claim
34 words
A pharmaceutical composition, comprising a liposome-encapsulated effective amount of a vinca alkaloid in complexation with cardiolipin, said vinca alkaloid being at least one member selected from the group consisting of vincristine, vinblastine and vindesine.
Claim 3
Dependent Claim
11 words
The composition of claim 1, wherein said vinca alkaloid is vincristine.
Claim 4
Dependent Claim
11 words
The composition of claim 1, wherein said vinca alkaloid is vinblastine.
Claim 5
Dependent Claim
11 words
The composition of claim 1, wherein said vinca alkaloid is vindesine.
Claim 6
Dependent Claim
56 words
The composition of claim 1, which comprises from 6.8 to 9.2 parts by weight of vinca alkaloid, from 30.6 to 41.4 parts by weight of cardiolipin, from 102 to 138 parts by weight of phosphatidylcholine, from 34 to 46 parts by weight of cholesterol and from 6.8 to 9.2 parts by weight of phosphatidylserine or dicetylphosphate.
Claim 7
Independent Claim
55 words
A method of treating a tumor in a patient in need thereof, comprising administering to said patient an effective amount of a pharmaceutical composition, comprising a liposome-encapsulated effective amount of a vinca alkaloid in complexation with cardiolipin, said vinca alkaloid being at least one member selected from the group consisting of vincristine, vinblastine and vindesine.
Claim 8
Independent Claim
55 words
A method of treating a tumor in a patient in need thereof, comprising administering to said patient an effective amount of a pharmaceutical composition, comprising a liposome-encapsulated effective amount of a vinca alkaloid in complexation with cardiolipin, said vinca alkaloid being at least one member selected from the group consisting of vincristine, vinblastine and vindesine.
Claim 9
Dependent Claim
11 words
The method of claim 6, wherein said vinca alkaloid is vincristine.
Claim 10
Dependent Claim
11 words
The method of claim 6, wherein said vinca alkaloid is vinblastine.
Claim 11
Dependent Claim
11 words
The method of claim 6, wherein said vinca alkaloid is vindesine.
Claim 12
Dependent Claim
26 words
The method of claim 6, wherein said tumor is a tumor caused by a non-hodgkin's lymphoma, Hodgkin's lymphoma, acute lymphoblastic leukemia, Wilm's tumor, rhabdomyosarcoma and neuroblastoma.
Claim 13
Dependent Claim
60 words
The method of claim 6, wherein said pharmaceutical composition comprises from 6.8 to 9.2 parts by weight of vinca alkaloid, from 30.6 to 41.4 parts by weight of a cardiolipin, from 102 to 138 parts by weight of phosphatidylcholine, from 34 to 46 parts by weight of cholesterol and from 6.8 to 9.2 parts by weight of phosphatidylserine or dicetylphosphate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-27 | 1994-02-26 | 1994-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-27 | 1998-02-26 | 1998-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-27 | 2002-02-26 | 2002-08-28 | $7700.00 | Window Closed / Lapsed |