US4947842A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for treating tissue with first and second modalities
Assignee: Cook Research Inc
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Filing: 1989-02-13
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Granted: 1990-08-14
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Expires: 2009-02-13
Abstract
Abstract Method and apparatus is disclosed for treating tissue interstitially with multiple modalities of treatment. The apparatus comprises a semi-rigid elongated member that is implanted interstitially in the malignant tumor. A hollow passageway is longitudinally positioned in the member for positioning one or more modalities inserted or positioned therein. The elongated member is coated with another modality such as a carrier substance that is responsive at a temperature above normal tissue temperature for releasing a carried substance such as a therapeutic anti-cancer drug. Within the elongated member, an electrical heater element for one modality produces heat when energized for heating the probe, the carrier substance, the anti-cancer drug, and the surrounding tissue. A second modality such as a source of radiation is inserted in the passageway after the probe is interstitially implanted. A trocar stylet is initially inserted in the passageway to implant the probe. When the probe is implanted, the trocar stylet is removed, and the heater element and/or source of radiation is inserted into the passageway. The several modalities combine in a synergistic manner to provide an overall treatment that has an effectiveness level greater than the sum of the individual modalities.
Inventors
- 👤 Jose A. Marchosky
- 👤 Christopher J. Moran
- 👤 Neal E. Fearnot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:41
CPC Classifications
A; A61; A61F; A61F7/00; A61F7/12; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1007; A61N2005/1011; A61N2005/1012; A61N5/1027
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
72 words
Apparatus for treating tissue, comprising: an elongated member interstitially implantable in said tissue and having a distal end for interstitially penetrating said tissue; a passageway longitudinally positioned in said member for positioning a first modality in said member, said first modality for providing a first treatment of said tissue; and a second modality positioned about said distal end and responsive to said first modality for providing a second treatment of said tissue.
Claim 2
Dependent Claim
72 words
Apparatus for treating tissue, comprising: an elongated member interstitially implantable in said tissue and having a distal end for interstitially penetrating said tissue; a passageway longitudinally positioned in said member for positioning a first modality in said member, said first modality for providing a first treatment of said tissue; and a second modality positioned about said distal end and responsive to said first modality for providing a second treatment of said tissue.
Claim 3
Dependent Claim
25 words
The apparatus of claim 1 further comprising said first modality including a heater element insertable into said passageway for producing heat for said first treatment.
Claim 4
Dependent Claim
38 words
The apparatus of claim 2 wherein said second modality comprises a carried and a carrier substance joined with said elongated member, said carrier substance being responsive to said heat for releasing said carried substance for said second treatment.
Claim 5
Dependent Claim
31 words
The apparatus of claim 1 further comprising said first modality including a second elongated member insertable into said passageway and a source of radiation for said first treatment of said tissue.
Claim 6
Dependent Claim
22 words
The apparatus of claim 4 wherein said second modality includes a heater element positioned about said distal end for said second treatment.
Claim 7
Dependent Claim
30 words
The apparatus of claim 5 further comprising a drug joined with said distal end of said member and responsive to said heat for providing a third treatment of said tissue.
Claim 8
Dependent Claim
15 words
The apparatus of claim 4 wherein said elongated member includes an aperture for said passageway.
Claim 9
Dependent Claim
25 words
The apparatus of claim 7 further comprising a stylet insertable into said passageway through said aperture for implanting said elongated member interstitially in said tissue.
Claim 10
Dependent Claim
21 words
The apparatus of claim 4 wherein said second modality includes a drug joined with said elongated member for said second treatment.
Claim 11
Dependent Claim
35 words
The apparatus of claim 1 further comprising a third modality positioned about said distal end and responsive to at least one of said first and second modalities for providing a third treatment of said tissue.
Claim 12
Dependent Claim
18 words
The apparatus of claim 1 wherein said member includes an aperture for inserting a stylet into said passageway.
Claim 13
Dependent Claim
21 words
The apparatus of claim 1 further comprising a stylet insertable into said passageway for implanting said member interstitially in said tissue.
Claim 14
Dependent Claim
27 words
The apparatus of claim 1 wherein said member includes an aperture positioned about said distal end for delivering said first modality from said passageway to said tissue.
Claim 15
Dependent Claim
73 words
Apparatus for treating tissue comprising: an elongated member interstitially implantable in said tissue and having a distal end for interstitially penetrating said tissue; a passageway longitudinally positioned in said member for positioning a heater element therein, said heater element for producing heat; and a coating layer joined with said member about said distal end and responsive to said heat for releasing at a predetermined temperature above a temperature of said tissue a drug.
Claim 16
Dependent Claim
73 words
Apparatus for treating tissue comprising: an elongated member interstitially implantable in said tissue and having a distal end for interstitially penetrating said tissue; a passageway longitudinally positioned in said member for positioning a heater element therein, said heater element for producing heat; and a coating layer joined with said member about said distal end and responsive to said heat for releasing at a predetermined temperature above a temperature of said tissue a drug.
Claim 17
Dependent Claim
10 words
The apparatus of claim 14 further comprising said heater element.
Claim 18
Independent Claim
59 words
A method for treating tissue with a first and a second modality of treatment, comprising: implanting an elongated member interstitially in said tissue; positioning said first modality in a passageway longitudinally positioned in said member; and responsive to said first modality, providing said second modality positioned about a distal end of said member when implanted interstitially in said tissue.
Claim 19
Independent Claim
59 words
A method for treating tissue with a first and a second modality of treatment, comprising: implanting an elongated member interstitially in said tissue; positioning said first modality in a passageway longitudinally positioned in said member; and responsive to said first modality, providing said second modality positioned about a distal end of said member when implanted interstitially in said tissue.
Claim 20
Dependent Claim
34 words
The method of claim 16 wherein said implanting comprises positioning a stylet in said passageway and inserting the distal end of said member interstitially in said tissue with said stylet positioned in said passageway.
Claim 21
Dependent Claim
42 words
The method of claim 17 wherein said positioning of said first modality includes removing said stylet from said passageway of said member when implanted in said tissue and positioning a heater element in said passageway for providing heat for said first modality.
Claim 22
Dependent Claim
26 words
The method of claim 18 further comprises positioning a source of radiation within a tube of said heater element, for providing a third modality of treatment.
Claim 23
Dependent Claim
34 words
The method of claim 18 wherein said providing includes releasing a drug at a temperature above a temperature of said tissue for said second modality in response to said heat from said first modality.
Claim 24
Dependent Claim
31 words
The method of claim 17 wherein said positioning of said first modality includes removing said stylet from said passageway of said member and positioning a source of radiation in said passageway.
Claim 25
Dependent Claim
150 words
Apparatus for treating tissue, comprising: an elongated member having a distal end for implanting said elongated member interstitially in said tissue; a passageway positioned longitudinally in said member; a stylet insertable into said passageway for implanting said member in said tissue; a heater element having a tube positioned therein and insertable into said passageway for producing heat for a first modality of treatment; a second elongated member insertable into said tube and including a source of radiation for a second modality of treatment; a coating layer joined with said member about said distal end responsive to said heat for releasing at a predetermined temperature above a temperature of said tissue a therapeutic substance for a third modality of treatment, the total effectiveness level of all of said modalities of treatment on said tissue being greater than the sum of each effectiveness level of said first, second, and third modalities individually.
Claim 26
Dependent Claim
150 words
Apparatus for treating tissue, comprising: an elongated member having a distal end for implanting said elongated member interstitially in said tissue; a passageway positioned longitudinally in said member; a stylet insertable into said passageway for implanting said member in said tissue; a heater element having a tube positioned therein and insertable into said passageway for producing heat for a first modality of treatment; a second elongated member insertable into said tube and including a source of radiation for a second modality of treatment; a coating layer joined with said member about said distal end responsive to said heat for releasing at a predetermined temperature above a temperature of said tissue a therapeutic substance for a third modality of treatment, the total effectiveness level of all of said modalities of treatment on said tissue being greater than the sum of each effectiveness level of said first, second, and third modalities individually.
Claim 27
Dependent Claim
72 words
Apparatus for treating tissue, comprising: an elongated member interstitially implantable in said tissue and having a distal end for interstitially penetrating said tissue; a passageway longitudinally positioned in said member for positioning a first modality in said member, said first modality for providing a first treatment of said tissue; and a second modality positioned about said distal end and interactive with said first modality for providing a second treatment of said tissue.
Claim 28
Dependent Claim
72 words
Apparatus for treating tissue, comprising: an elongated member interstitially implantable in said tissue and having a distal end for interstitially penetrating said tissue; a passageway longitudinally positioned in said member for positioning a first modality in said member, said first modality for providing a first treatment of said tissue; and a second modality positioned about said distal end and interactive with said first modality for providing a second treatment of said tissue.
Claim 29
Dependent Claim
32 words
The apparatus of claim 23 further comprising a third modality positioned about said distal end and interactive with at least one of said first and second modalities for providing a third treatment.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-13 | 1994-02-12 | 1994-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-13 | 1998-02-12 | 1998-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-13 | 2002-02-12 | 2002-08-14 | $7700.00 | Window Closed / Lapsed |