US4638045A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-peptide polyamino acid bioerodible polymers
Assignee: Massachusetts Institute of Technology
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Filing: 1985-02-19
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Granted: 1987-01-20
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Expires: 2005-02-19
Abstract
Abstract A novel bioerodible polymeric composition is provided comprising a plurality of monomer units of two or three amino acids which are polymerized via hydrolytically labile bonds at their respective side chains rather than at the amino or carboxylic acid terminals by amide bonds. Such polymers are useful for controlled release applications in vivo and in vitro for delivery of a wide variety of biologically and pharmacologically active ligands.
Inventors
- 👤 Joachim Kohn
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:36
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/29
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
85 words
A bioerodible polymer formed by polymerizing a dipeptide formed exclusively of L-alpha amino acids of the formula: ##STR20## or by polymerizing a tripeptide formed exclusively of L-alpha amino acids of the formula: ##STR21## wherein at least one of Z or Y is an amine or carboxyl protecting group and wherein polymerization is effected through at least one of R 1 , R 2 or R 3 without the formation of additional peptide bonds through the terminal, amine and carboxyl groups of said dipeptide or tripeptide.
Claim 2
Dependent Claim
85 words
A bioerodible polymer formed by polymerizing a dipeptide formed exclusively of L-alpha amino acids of the formula: ##STR20## or by polymerizing a tripeptide formed exclusively of L-alpha amino acids of the formula: ##STR21## wherein at least one of Z or Y is an amine or carboxyl protecting group and wherein polymerization is effected through at least one of R 1 , R 2 or R 3 without the formation of additional peptide bonds through the terminal, amine and carboxyl groups of said dipeptide or tripeptide.
Claim 3
Dependent Claim
19 words
The bioerodible polymer as recited in claim 1 wherein at least Y or Z is a pharmacologically active ligand.
Claim 4
Dependent Claim
15 words
The bioerodible polymer as recited in claim 2 wherein Y is a pharmacologically active ligand.
Claim 5
Dependent Claim
15 words
The bioerodible polymer as recited in claim 2 wherein Z is a pharmacologically active ligand.
Claim 6
Dependent Claim
35 words
The biodegradable polymer as recited in claim 1 wherein said hydrolytic labile bond is selected from the group consisting of imidocarbonate bonds, anhydride bonds, aromatic ester bonds, aliphatic ester bonds, sulfide bonds and imidazolide bonds.
Claim 7
Dependent Claim
29 words
The bioerodible polymer as recited in claim 1 wherein Z and Y comprise protecting groups of the amino terminal end and the carboxyl terminal end of the monomer unit.
Claim 8
Dependent Claim
14 words
The bioerodible polymer of claim 2 wherein the pharmacologically active ligand is a drug.
Claim 9
Dependent Claim
11 words
The bioerodible polymer of claim 7 wherein the drug is methotrexate.
Claim 10
Dependent Claim
15 words
The bioerodible polymer of claim 1 wherein at least one L-alpha amino acid is tyrosine.
Claim 11
Dependent Claim
15 words
The bioerodible polymer of claim 1 wherein at least one L-alpha amino acid is glutamine.
Claim 12
Dependent Claim
15 words
The bioerodible polymer of claim 1 wherein at least one L-alpha amino acid is phenylalanine.
Claim 13
Dependent Claim
15 words
The bioerodible polymer of claim 1 wherein at least one L-alpha amino acid is histidine.
Claim 14
Dependent Claim
15 words
The bioerodible polymer of claim 1 wherein at least one L-alpha amino acid is cysteine.
Claim 15
Dependent Claim
16 words
The composition of claim 1 which includes a pharmacologically active agent physically admixed within said polymer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-19 | 1990-07-21 | 1991-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-19 | 1994-07-21 | 1995-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-19 | 1998-07-21 | 1999-01-20 | $7700.00 | Window Closed / Lapsed |