Patent US4942231A successfully refreshed from Google Patents.
US4942231A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
Assignee: Mallinckrodt Inc
•
Filing: 1985-05-17
•
Granted: 1990-07-17
•
Expires: 2005-05-17
Abstract
Abstract The invention relates to a method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound, in which the (hetero)aromatic nucleus optionally comprises one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in the presence of a water-soluble acid and of copper ions as a catalyst with a likewise water-soluble chloride, bromide radiobromide, iodide or radio-iodide, in which the reaction is carried out in the presence of one or more reduction agents, which are stable in acid medium, in a quantity exceeding the quantity of catalyst. The invention also relates to a composition suitable for diagnostic examination and to a kit for the preparation thereof. The invention further relates to a method and an equipment for the preparation of said composition.
Inventors
- 👤 John Mertens
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:26
CPC Classifications
C; C07; C07C; C07C63/00; C07C63/68; C07C63/70; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/12; A61K51/1282; A61M; A61M5/00; A61M5/178; A61M5/31; C07B; C07B39/00; C07C45/00; C07C45/61; C07C45/63; C07C51/00; C07C51/347; C07C51/363; C07C57/00; C07C57/52; C07C57/58; A61K2123/00; C07B2200/00; C07B2200/05
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
88 words
In a method for preparing a chlorinated, brominated, radiobrominated, iodinated or radioiodinated aromatic or heteromatic compound, in which said compound may be optionally substituted with one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in an acid medium in the presence of copper ions as a catalyst with a water-soluble chloride, bromide, radiobromide, iodide or radioiodide, the improvement comprising conducting the reaction in the presence of a reducing agent, which is stable in acid medium, in a quantity exceeding the quantity of the catalyst.
Claim 2
Dependent Claim
88 words
In a method for preparing a chlorinated, brominated, radiobrominated, iodinated or radioiodinated aromatic or heteromatic compound, in which said compound may be optionally substituted with one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in an acid medium in the presence of copper ions as a catalyst with a water-soluble chloride, bromide, radiobromide, iodide or radioiodide, the improvement comprising conducting the reaction in the presence of a reducing agent, which is stable in acid medium, in a quantity exceeding the quantity of the catalyst.
Claim 3
Dependent Claim
14 words
A method of claim 1 wherein the reducing agent is a Sn (II) salt.
Claim 4
Dependent Claim
33 words
A method of claim 1 wherein the reaction is conducted in the presence of an antioxidant selected from the group consisting of metallic tin, ascorbic acid, citric acid, a monosaccharide and gentisic acid.
Claim 5
Dependent Claim
33 words
A method of claim 2 wherein the reaction is conducted in the presence of an antioxidant selected from the group consisting of metallic tin, ascorbic acid, citric acid, a monosaccharide and gentisic acid.
Claim 6
Dependent Claim
16 words
A method of claim 2 wherein the reaction is conducted in the presence of ascorbic acid.
Claim 7
Dependent Claim
27 words
A method of claim 1 wherein the reducing agent is selected from the group consisting of ascorbic acid, isoascorbic acid, citric acid, a monosaccharide and a sulphite.
Claim 8
Dependent Claim
12 words
A method of claim 1 wherein the reducing agent is ascorbic acid.
Claim 9
Dependent Claim
18 words
A method of claim 1, 2 or 5 wherein the reaction is carried out in an aqueous solution.
Claim 10
Dependent Claim
22 words
A method of claim 1, 2, or 5 wherein the reaction is carried out in an aqueous solution and a water-miscible solvent.
Claim 11
Dependent Claim
21 words
A method of claim 1, 2, or 5 wherein the reaction is carried out at a temperature of about 100° C.
Claim 12
Dependent Claim
14 words
A method of claim 9 wherein the water-miscible solvent comprises ethanol, methanol or acetone.
References Cited (Backward Citations)
US3814769A
Cited
US3859429A
Cited
EP0011858A1
Cited
US4298591A
Cited
EP0081193A2
Cited
EP0165630A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-07-16 | 1994-01-15 | 1994-07-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-16 | 1998-01-15 | 1998-07-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-16 | 2002-01-15 | 2002-07-17 | $7700.00 | Window Closed / Lapsed |