Patent US4935244A successfully refreshed from Google Patents.
US4935244A
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US
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Nedocromil sodium compositions and methods for their preparation
Assignee: Fisons Ltd
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Filing: 1988-11-17
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Granted: 1990-06-19
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Expires: 2008-11-17
Abstract
Abstract There is described a pharmaceutical composition comprising nedocromil sodium and liposomes. There is also described an aqueous suspension comprising nedocromil sodium partitioned between a free aqueous phase and a liposome phase. There ae also described a method of making the compositions and their use in the manufacture of a medicament for the treatment of reversible obstructive airways disease.
Inventors
- 👤 Andrew R. Clark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K9/00; A61K9/10; A61K9/127; A61P; A61P11/00; A61P11/08
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
21 words
A pharmaceutical composition comprising an aqueous suspension containing nedocromil sodium partitioned between a free aqueous phase and a liposome entrapped phase.
Claim 2
Dependent Claim
21 words
A pharmaceutical composition comprising an aqueous suspension containing nedocromil sodium partitioned between a free aqueous phase and a liposome entrapped phase.
Claim 3
Dependent Claim
22 words
A pharmaceutical composition according to claim 1 wherein the entrapment ratio of nedocromil sodium is from 0.1 to 50% w/w nedocromil sodium/lipid.
Claim 4
Dependent Claim
23 words
A pharmaceutical composition according to claim 1 wherein the concentration of the entrapped aqueous nedocromil sodium solution is from 0.1% to 40% w/v.
Claim 5
Dependent Claim
24 words
A pharmaceutical composition according to claim 1 comprising an aqueous suspension of liposomes wherein the concentration of liposomes is from 5% to 80% w/v.
Claim 6
Dependent Claim
30 words
A pharmaceutical composition according to claim 1 comprising an aqueous solution of nedocromil sodium substantially entrapped in a liposome phase having a total concentration of from 0.01% to 30% w/v.
Claim 7
Dependent Claim
19 words
A composition according to claim 1 wherein the liposomes have a diameter of from 100 μm to 10 μm.
Claim 8
Dependent Claim
17 words
A composition according to claim 1 wherein the liposomes comprise one or more natural or synthetic lecithins.
Claim 9
Dependent Claim
28 words
A process for the manufacture of a composition according to claim 1 which comprises dispersing a thin film of a lipid in an aqueous solution of nedocromil sodium.
Claim 10
Dependent Claim
25 words
A method of treatment of reversible obstructive airways disease which comprises administration of a therapeutically effective amount of a pharmaceutical composition according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-18 | 1993-12-18 | 1994-06-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-18 | 1997-12-18 | 1998-06-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-18 | 2001-12-18 | 2002-06-19 | $7700.00 | Window Closed / Lapsed |