US4760072A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid nedocromil sodium, useful for the removal of obstructed air pathways
Assignee: King Pharmaceuticals Inc
•
Filing: 1985-04-08
•
Granted: 1988-07-26
•
Expires: 2005-04-08
Abstract
Abstract There are described new forms of nedocromil sodium, methods of producing these new forms and pharmaceutical formulations, especially pressurized inhalation aerosol formulations, containing finely divided nedocromil sodium. The formulations are indicated for the treatment of reversible obstructive conditions of the airways.
Inventors
- 👤 Kenneth Brown
- 👤 Andrew R. Clark
- 👤 Richard Salliss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 13:00
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/008; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61P; A61P11/00; C; C07; C07D; C07D491/00; C07D491/02; C07D491/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
16 words
Solid nedocromil sodium which is cystalline and which contains bound water as determined by thermogravimetric analysis.
Claim 2
Dependent Claim
16 words
Solid nedocromil sodium which is cystalline and which contains bound water as determined by thermogravimetric analysis.
Claim 3
Dependent Claim
15 words
Solid nedocromil sodium according to claim 1 containing between 3.0 and 4.0% w/w bound water.
Claim 4
Dependent Claim
11 words
Solid nedocromil sodium according to claim 1 containing 3.5% bound water.
Claim 5
Dependent Claim
23 words
Nedocromil sodium according to claim 2 in powder form and having a Lovibond yellow reading of below 2.0 when containing 10% w/w water.
Claim 6
Dependent Claim
16 words
Nedocromil sodium according to claim 4 having a Lovibond yellow reading of between 0.8 and 1.8.
Claim 7
Dependent Claim
18 words
Nedocromil sodium according to claim 1, wherein the powder X-ray diffraction pattern shows that the material is crystalline.
Claim 8
Dependent Claim
24 words
Nedocromil sodium according to claim 1 whose infra-red spectrum shows a shoulder at 3500 cms -1 when its total water content is 10% w/w.
Claim 9
Dependent Claim
48 words
An inhalation formulation for treatment of a reversible obstructive condition of the airways comprising a pharmaceutically acceptable liquefied gas propellant containing nedocromil sodium according to claim 1 having a mass median diameter of less than 4 microns in a proportion which is effective for treatment of said condition.
Claim 10
Dependent Claim
42 words
A formulation according to claim 8, wherein not more than 5% by weight of the particles has a diameter of greater than 10 microns and not less than 90% by weight of the particles has a diameter of less than 6 microns.
Claim 11
Dependent Claim
18 words
A formulation according to claim 8, containing from 0.5 to 10% by weight of finely divided nedocromil sodium.
Claim 12
Dependent Claim
30 words
A formulation according to claim 8 comprising a mixture of propellants 12 and 114, the proportion of propellant 12 to 114 being in the range 2 to 1:1 by weight.
Claim 13
Dependent Claim
9 words
A formulation according to claim 11 containing sorbitan trioleate.
Claim 14
Dependent Claim
29 words
Nedocromil sodium in accordance with claim 1 the form of needles having a breadth of 1.5 to 3.5 microns and a length to breadth ratio of up to 10:1.
Claim 15
Dependent Claim
14 words
Nedocromil sodium according to claim 13 having a breadth of 1.5 to 2.5 microns.
Claim 16
Dependent Claim
38 words
A method of treatment of a reversible obstructive condition of the airways in a mammal which comprises administering by inhalation an effective amount of solid nedocromil sodium according to claim 1 to a mammal suffering from said condition.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-26 | 1992-01-25 | 1992-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-26 | 1996-01-25 | 1996-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-26 | 2000-01-25 | 2000-07-26 | $7700.00 | Window Closed / Lapsed |