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US4933441A
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Contrast enhancing agents for magnetic resonance images
Assignee: Individual
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Filing: 1989-04-17
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Granted: 1990-06-12
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Expires: 2009-04-17
Abstract
Abstract A nonionic contrast enhancing agent for magnetic resonance. In a preferred embodiment a chelating agent, for example, EDTA or DTPA, binds a metal, preferrably Gd, having at least one unpaired electron. Any carboxoyl groups not involved in chelation are bound to a reduced lower carbohydrate having between 3 and 5 carbon atoms. Such compositions are useful for enhancing the contrast of Magnetic Resonance images.
Inventors
- 👤 Wendell A. Gibby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:19
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/101; A61K49/103; A61K49/085; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
23 words
A magnetic resonance contrast enhancing agent comprising a chelating agent represented by the formula A: ##STR3## where m is 1, 2, or 3;
Claim 2
Dependent Claim
23 words
A magnetic resonance contrast enhancing agent comprising a chelating agent represented by the formula A: ##STR3## where m is 1, 2, or 3;
Claim 3
Dependent Claim
8 words
n is an integer between 1 and 4;
Claim 4
Dependent Claim
8 words
n is an integer between 1 and 4;
Claim 5
Dependent Claim
14 words
p can be independently varied and is an integer between 0 and 2; and
Claim 6
Dependent Claim
14 words
p can be independently varied and is an integer between 0 and 2; and
Claim 7
Dependent Claim
21 words
X and Y can be --(CH 2 ) p COOH or X is (CH 2 ) n and joined to Y;
Claim 8
Dependent Claim
21 words
X and Y can be --(CH 2 ) p COOH or X is (CH 2 ) n and joined to Y;
Claim 9
Dependent Claim
34 words
at least one carbohydrate selected from glycerol, adonitol, arabitol, erythritol, pentaerythritol, xylitol bound to said chelating agent through an ester linkages of one of said (COOH) groups and (OH) groups of the carbohydrate; and
Claim 10
Dependent Claim
34 words
at least one carbohydrate selected from glycerol, adonitol, arabitol, erythritol, pentaerythritol, xylitol bound to said chelating agent through an ester linkages of one of said (COOH) groups and (OH) groups of the carbohydrate; and
Claim 11
Dependent Claim
31 words
a metal ion having at least one unpaired electron chelated to a compound of formula A, provided that all (COOH) groups not involved in metal chelation are bound to a carbohydrate.
Claim 12
Dependent Claim
31 words
a metal ion having at least one unpaired electron chelated to a compound of formula A, provided that all (COOH) groups not involved in metal chelation are bound to a carbohydrate.
Claim 13
Dependent Claim
25 words
The magnetic resonance contrast enhancing agent of claim 1 wherein a component of formula A is selected from the group of EDTA, DTPA, and DOTA.
Claim 14
Dependent Claim
21 words
The magnetic resonance contrast enhancing agent of claim 1 wherein said metal ion is selected from the lanthanide group of metals.
Claim 15
Dependent Claim
15 words
The magnetic resonance contrast enhancing agent of claim 3 wherein said metal ion is Gd.
References Cited (Backward Citations)
US4822594A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-11 | 1993-12-11 | 1994-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-11 | 1997-12-11 | 1998-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-11 | 2001-12-11 | 2002-06-12 | $7700.00 | Window Closed / Lapsed |