Patent US4929601A successfully refreshed from Google Patents.
US4929601A
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Tripeptides useful as immunostimulants as well as in the prevention of metastases
Assignee: Ellem Industria Farmaceutica SpA
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Filing: 1988-08-02
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Granted: 1990-05-29
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Expires: 2008-08-02
Abstract
Abstract The present invention is referred to tripeptides having the following general formula: X-Gly-Y where X=L-Arg or D-Arg and Y=L-Asp or D-Asp. These tripeptides, endowed with both immunostimulant and antimetastatic properties, are active not only after parenteral administration, but also after oral treatment. The invention is also related to the procedure for the preparation of said compounds.
Inventors
- 👤 Brunetto Brunetti
- 👤 Marco Prada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:59
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0815; C07K5/0817; A; A61; A61P; A61P35/00; A61P37/00; A61P37/02; A61P37/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
46 words
A method of treating a metastatic disorder comprising administering to a subject in need of treatment, a pharmaceutically effective amount of a tripeptide of the general formula X-Gly-Y where X is L-Arg or D-Arg and Y is L-Asp or D-Asp, or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
46 words
A method of treating a metastatic disorder comprising administering to a subject in need of treatment, a pharmaceutically effective amount of a tripeptide of the general formula X-Gly-Y where X is L-Arg or D-Arg and Y is L-Asp or D-Asp, or a pharmaceutically acceptable salt thereof.
Claim 3
Independent Claim
46 words
A method of treating an immunological disorder comprising administering to a subject in need of treatment, a pharmaceutically effective amount of a tripeptide of the general formula X-Gly-Y where X is L-Arg or D-Arg and Y is L-Asp or D-Asp, or a pharmaceutically acceptable salt thereof.
Claim 4
Independent Claim
46 words
A method of treating an immunological disorder comprising administering to a subject in need of treatment, a pharmaceutically effective amount of a tripeptide of the general formula X-Gly-Y where X is L-Arg or D-Arg and Y is L-Asp or D-Asp, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
18 words
A method according to claim 2 which comprises orally administering the tripeptides or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
18 words
A method according to claim 2 which comprises parenterally administering the tripeptides or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
18 words
A method according to claim 1 which comprises parenterally administering the tripeptides or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
17 words
A method according to claim 1 which comprises administering the tripeptides or a pharmaceutically acceptable salt thereof.
Claim 9
Independent Claim
52 words
A method for reducing metastases and improving the immune response of a subject who has undergone surgical removal of a tumor, comprising administering a pharmaceutically effective amount of a tripeptide the general formula X-Gly-Y wherein X is L-Arg or D-Arg and Y is L-Asp or D-Asp, or a pharmaceutically acceptable salt thereof.
Claim 10
Independent Claim
52 words
A method for reducing metastases and improving the immune response of a subject who has undergone surgical removal of a tumor, comprising administering a pharmaceutically effective amount of a tripeptide the general formula X-Gly-Y wherein X is L-Arg or D-Arg and Y is L-Asp or D-Asp, or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
13 words
A method according to claim 1 including administering acetate salts of the tripeptides.
Claim 12
Dependent Claim
13 words
A method according to claim 6 including administering trifluoroacetate salts of the tripeptides.
Claim 13
Dependent Claim
13 words
A method according to claim 6 including administering hydrochloride salts of the tripeptides.
Claim 14
Dependent Claim
13 words
A method according to claim 6 including administering sulfate salts of the tripeptides.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-28 | 1993-11-27 | 1994-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-28 | 1997-11-27 | 1998-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-28 | 2001-11-27 | 2002-05-29 | $7700.00 | Window Closed / Lapsed |