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US4929313A
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Amperometric electrochemical ion sensors and method for determining ion concentration
Assignee: Massachusetts Institute of Technology
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Filing: 1988-01-04
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Granted: 1990-05-29
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Expires: 2008-01-04
Abstract
Abstract Electrochemical devices constructed according to the present invention can be used to convert an ion flux into an electric current for determination of ion concentration. The devices are operated without the need for a reference electrode and are specific based on known ion transfer agents. Operation of the devices involves the use of pairs of electrodes modified with electroactive redox materials overlaid with ion selective coatings. An applied potential between a pair of appropriately modified electrodes results in the flow of an electric current between the electrodes which is dependent on the concentration of the ion to be sensed. Devices constructed by combining electrodes overlaid with electroactive polymers and different ion selective films allow simultaneous determination of diverse ions. For example, these devices are useful for measuring the concentration of total cations, total anions, H + , Li + , K + , Ca 2+ , Na + , HCO 3 - , Cl - , other cations and anions, and combinations thereof. The devices are small and stable enough to be used in vivo, for example, as blood monitoring means, or in large scale water quality monitoring or purification/separations techniques.
Inventors
- 👤 Mark S. Wrighton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:19
CPC Classifications
H; H10; H10K; H10K10/00; H10K10/701; B; B82; B82Y; B82Y10/00; G; G01; G01N; G01N27/00; G01N27/26; G01N27/403; G01N27/414; G02; G02F; G02F1/00; G02F1/01; G02F1/15; G02F1/153; G02F1/1533; H01; H01G; H01G7/00; H10K85/00; H10K85/10; H10K85/111; H10K85/30; H10K71/00; H10K71/10; H10K71/12; H10K71/125
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
62 words
An amperometric electrochemical sensor comprising: a pair of electrically conductive electrodes each overlaid with electroactive polymeric material, at least one electrode having an ion-selective coating thereon, wherein said electrodes are electrically connected and said coating actively and selectively transports ions into the electroactive polymeric material effecting a change in the measured current correlated with the concentration of a substance to be measured.
Claim 2
Dependent Claim
62 words
An amperometric electrochemical sensor comprising: a pair of electrically conductive electrodes each overlaid with electroactive polymeric material, at least one electrode having an ion-selective coating thereon, wherein said electrodes are electrically connected and said coating actively and selectively transports ions into the electroactive polymeric material effecting a change in the measured current correlated with the concentration of a substance to be measured.
Claim 3
Dependent Claim
27 words
The amperometric ion sensor of claim 1 further comprising means for applying a potential between said electrically conductive electrodes and means for measuring current between said electrodes.
Claim 4
Dependent Claim
23 words
The amperometric electrochemical ion sensor of claim 1 wherein said electroactive polymeric material is a polymer formed from electrochemically polymerizable redox active polymers.
Claim 5
Dependent Claim
22 words
The ion sensor of claim 3 wherein said polymer is selected from the group consisting of polypyrrole, poly-N-methylpyrrole, polythiophene, polyvinylferrocene, and viologens.
Claim 6
Dependent Claim
16 words
The ion sensor of claim 1 wherein said ion-selective coating is selective for cations or anions.
Claim 7
Dependent Claim
40 words
The ion sensor of claim 5 wherein the coating transmits an ion selected from the group consisting of H + , Li + , K + , Ca 2+ , Na + , HCO 3 - and Cl - .
Claim 8
Dependent Claim
22 words
The ion sensor of claim 5 wherein the ion-selective coating is selected from the group consisting of valinomycin, Nafion™, ionophores, and polyvinylpyridine.
Claim 9
Dependent Claim
10 words
The ion sensor of claim 1 further comprising an electrolyte.
Claim 10
Dependent Claim
24 words
The ion sensor of claim 1 further comprising additional pairs of electrodes overlaid with a different combination of electroactive polymeric materials and ion-selective coatings.
Claim 11
Dependent Claim
14 words
The sensor of claim 1 wherein the ions are the substance to be measured.
Claim 12
Dependent Claim
16 words
The sensor of claim 1 wherein the ions are indicative of the substance to be measured.
Claim 13
Independent Claim
65 words
A method for determining ion concentration comprising providing a pair of electrically conductive electrodes each overlaid with electroactive polymeric material, at least one electrode having an ion-selective coating thereon, wherein said electrodes are electrically connected and said coating actively and selectively transports ions into the electroactive polymeric material effecting a change in the measured current correlated with the concentration of a substance to be measured.
Claim 14
Independent Claim
65 words
A method for determining ion concentration comprising providing a pair of electrically conductive electrodes each overlaid with electroactive polymeric material, at least one electrode having an ion-selective coating thereon, wherein said electrodes are electrically connected and said coating actively and selectively transports ions into the electroactive polymeric material effecting a change in the measured current correlated with the concentration of a substance to be measured.
Claim 15
Dependent Claim
25 words
The method of claim 12 further comprising providing means for applying a potential to said electrically conductive electrodes and measuring the current between said electrodes.
Claim 16
Dependent Claim
41 words
The method of claim 13 further comprising applying a potential to the electrically conductive electrodes and calculating the ion concentration from changes in current as a function of the presence of ions in the electroactive polymeric material underlying the ion-selective coating.
Claim 17
Dependent Claim
18 words
The method of claim 13 further comprising placing the electrically connected electrodes in an electrolyte and measuring pH.
Claim 18
Dependent Claim
38 words
The method of claim 13 further comprising placing the electrically conductive electrodes in a body fluid selected from the group consisting of blood, lymph, tissue extract, and dialysates thereof and measuring the change in current between said electrodes.
Claim 19
Dependent Claim
19 words
The method of claim 12 further comprising selecting the ion-selective coating to transmit cations, anions, or a specific ion.
Claim 20
Dependent Claim
42 words
The method of claim 17 wherein the coating is selected to transmit an ion selected from the group consisting of H + , Li + , K + , Ca 2+ , Na + , HCO 3 - and Cl - .
Claim 21
Dependent Claim
24 words
The method of claim 12 further comprising providing additional pairs of electrodes overlaid with a different combination of electroactive polymeric materials and ion-selective coatings.
Claim 22
Dependent Claim
50 words
The method of claim 19 further comprising selecting the electroactive polymeric materials and ion-selective coatings to enable determination of the concentration of total cations, total anions, H + , Li + , K + , Ca 2 +, Na + , HCO 3 - , Cl - and combinations thereof.
Claim 23
Dependent Claim
40 words
The method of claim 20 further comprising applying a potential to the electrically conductive electrodes and calculating ion concentrations from changes in current as a function of the presence of ions in the electroactive polymeric material underlying the ion-selective coatings.
Claim 24
Dependent Claim
14 words
The method of claim 12 wherein the ions are the substance to be measured.
Claim 25
Dependent Claim
16 words
The method of claim 12 wherein the ions are indicative of the substance to be measured.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-28 | 1993-11-27 | 1994-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-28 | 1997-11-27 | 1998-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-28 | 2001-11-27 | 2002-05-29 | $7700.00 | Window Closed / Lapsed |