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Patent US4925925A successfully refreshed from Google Patents.
US4925925A
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Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use
Assignee: University of Cincinnati
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Filing: 1989-04-04
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Granted: 1990-05-15
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Expires: 2009-04-04
Abstract
Abstract A composition of matter having the following general formula ##STR1## wherein L represents 2-hydroxy isobutyric acid. This composition of matter is useful in improving the reaction efficiency or yield when bonding rhenium to a chelating ligand preferably a polydentate sulfur, selenium, phosphorous or nitrogen ligand. This provides a method to bond radioactive rhenium to various chelating ligands for a radiopharmaceutical. Further, this also provides a method to bond a radioactive rhenium to a protein such as a monoclonal antibody. This in turn provides a method to provide beta emitting radiation to cancer cells.
Inventors
- 👤 Edward A. Deutsch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:22
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/58; G01N33/60; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; C; C07; C07C; C07C51/00; C07C51/41; C07C51/418; C07C59/00; C07C59/01; C07F; C07F13/00; C07F13/005; A61K2123/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
78 words
A method of bonding rhenium 186 or rhenium-188 to a chelating ligand comprising forming a complex Re(O)L 1 -L 4 - X + wherein L 1 -L 4 represent 2-hydroxy isobutyric acid and X is an anion and reacting said Re(O)L 1 -L 4 - X + with a chelating ligand selected from the group consisting of multidentate ligands having chelating moieties selected from the group consisting of sulfur, nitrogen, phosphorous, arsenic, selenium, isonitrile, oxygen and combinations thereof.
Claim 2
Independent Claim
78 words
A method of bonding rhenium 186 or rhenium-188 to a chelating ligand comprising forming a complex Re(O)L 1 -L 4 - X + wherein L 1 -L 4 represent 2-hydroxy isobutyric acid and X is an anion and reacting said Re(O)L 1 -L 4 - X + with a chelating ligand selected from the group consisting of multidentate ligands having chelating moieties selected from the group consisting of sulfur, nitrogen, phosphorous, arsenic, selenium, isonitrile, oxygen and combinations thereof.
Claim 3
Dependent Claim
14 words
The method claimed in claim 1 wherein said chelating ligands are thiolate ligands. PG,20
Claim 4
Dependent Claim
24 words
The method claimed in claim 1 wherein said chelating ligands are selected from the group consisting of tetradentate ligands, tridentate ligands, and hexadentate ligands.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-14 | 1993-11-13 | 1994-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-14 | 1997-11-13 | 1998-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-14 | 2001-11-13 | 2002-05-15 | $7700.00 | Window Closed / Lapsed |