US4707544A
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US
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Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
Assignee: Massachusetts Institute of Technology
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Filing: 1984-11-28
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Granted: 1987-11-17
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Expires: 2004-11-28
Abstract
Abstract A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
Inventors
- 👤 Alun G. Jones
- 👤 Alan Davison
- 👤 Michael J. Abrams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:03
CPC Classifications
C; C07; C07F; C07F13/00; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0476; C07F3/00; C07F3/06; A61K2123/00
Claims Analysis
Total Claims: 58
Claim 1
Independent Claim
123 words
A method for preparing a coordination complex of an isonitrile ligand and a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta said method comprising preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the class consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination complex.
Claim 2
Independent Claim
123 words
A method for preparing a coordination complex of an isonitrile ligand and a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta said method comprising preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the class consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination complex.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein said displaceable metal is selected from the class consisting of Zn, Ga, Cd, In, Hg, Tl, Pb and Bi.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said radioactive metal is Tc.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said radioactive metal is Re.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein said isonitrile ligand is aliphatic.
Claim 7
Dependent Claim
13 words
The method of claim 1 wherein said isonitrile ligand is a hydrocarbon isonitrile.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein said isonitrile ligand is a saturated hydrocarbon isonitrile.
Claim 9
Dependent Claim
13 words
The method of claim 1 wherein said isonitrile ligand is a monodentate ligand.
Claim 10
Dependent Claim
13 words
The method of claim 1 wherein said isonitrile ligand is a bidentate ligand.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein said isonitrile ligand is a polydentate ligand.
Claim 12
Dependent Claim
22 words
The method of claim 1 wherein said radioactive metal is a radioactive isotope of Tc, Ru, Co, Pt, Fe, Os or Ir.
Claim 13
Dependent Claim
19 words
The method of claim 1 wherein said radioactive metal is a radioactive isotope of W, Re, Fe or Os.
Claim 14
Dependent Claim
29 words
The method of claim 1 wherein said radioative metal is a radioactive isotope of Cr, Mo, Co, Tc, Fe, Mn, W, Ru, Ni, Rh, Ir, Pd, Nb or Ta.
Claim 15
Dependent Claim
11 words
The method of claim 1 wherein said displaceable metal is zinc.
Claim 16
Dependent Claim
11 words
The method of claim 14 wherein said radioactive metal is Tc.
Claim 17
Dependent Claim
11 words
The method of claim 14 wherein said radioactive metal is Tc-99m.
Claim 18
Dependent Claim
11 words
The method of claim 16 wherein said radioactive metal is Re.
Claim 19
Dependent Claim
11 words
The method of claim 16 wherein said isonitrile ligand is aliphatic.
Claim 20
Dependent Claim
13 words
The method of claim 16 wherein said isonitrile ligand is a hydrocarbon isonitrile.
Claim 21
Dependent Claim
14 words
The method of claim 16 wherein said isonitrile ligand is a saturated hydrocarbon isonitrile.
Claim 22
Dependent Claim
13 words
The method of claim 16 wherein said isonitrile ligand is a monodentate ligand.
Claim 23
Dependent Claim
13 words
The method of claim 16 wherein said isonitrile ligand is a bidentate ligand.
Claim 24
Dependent Claim
13 words
The method of claim 16 wherein said isonitrile ligand is a polydentate ligand.
Claim 25
Dependent Claim
13 words
The method of claim 16 wherein said isonitrile ligand is a butyl isonitrile.
Claim 26
Dependent Claim
13 words
The method of claim 16 wherein said isonitrile ligand is tertiary butyl isonitrile.
Claim 27
Dependent Claim
14 words
The method of claim 16 wherein said isonitrile ligand is n-butyl or sec-butyl isonitrile.
Claim 28
Dependent Claim
14 words
The method of claim 16 wherein said isonitrile ligand is n-propyl or isopropyl isonitrile.
Claim 29
Dependent Claim
12 words
The method of claim 16 wherein said isonitrile ligand is cyclohexyl isonitrile.
Claim 30
Dependent Claim
118 words
A kit for preparing a coordination complex of an isonitrile ligand and a radionuclide selected from the class consisting of radioactive isotope of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, said kit comprising a predetermined quantity of (a) a adduct of a salt of a displaceable metal and said isonitrile ligand and (b) a predetermined quantity of reducing agent capable of reducing a predetermined quantity of a preselected one of said radionuclides to form said complex by displacing the displaceable metal from said ligand with said radionuclide, said displaceable metal being selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi.
Claim 31
Dependent Claim
118 words
A kit for preparing a coordination complex of an isonitrile ligand and a radionuclide selected from the class consisting of radioactive isotope of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, said kit comprising a predetermined quantity of (a) a adduct of a salt of a displaceable metal and said isonitrile ligand and (b) a predetermined quantity of reducing agent capable of reducing a predetermined quantity of a preselected one of said radionuclides to form said complex by displacing the displaceable metal from said ligand with said radionuclide, said displaceable metal being selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi.
Claim 32
Dependent Claim
18 words
A kit as claimed in claim 29 wherein said isonitrile adduct and said reducing agent are each lyophilized.
Claim 33
Dependent Claim
24 words
A kit a claimed in claim 29 wherein said lyophilized isonitrile adduct and said reducing agent are each contained in a sealed, sterilized container.
Claim 34
Dependent Claim
16 words
A kit as claimed in claim 29 wherein said preselected radionuclide is an isotope of Tc.
Claim 35
Dependent Claim
20 words
A kit as claimed in claim 31 wherein said adduct and said reducing agent are contained in the same container.
Claim 36
Dependent Claim
23 words
A kit as claimed in claim 29 wherein said displaceable metal is selected from Zn, Ga, Cd, In, Hg, Tl, Pb or Bi.
Claim 37
Dependent Claim
13 words
A kit as claimed in claim 29 wherein said displaceable metal is zinc.
Claim 38
Dependent Claim
15 words
A kit as claimed in claim 35 wherein said isonitrile ligand is a butyl isonitrile.
Claim 39
Dependent Claim
15 words
A kit as claimed in claim 35 wherein said isonitrile ligand is tertiary butyl isonitrile.
Claim 40
Dependent Claim
17 words
A kit as claimed in claim 35 wherein said isonitrile ligand is n-butyl isonitrile or sec-butyl isonitrile.
Claim 41
Dependent Claim
16 words
A kit as claimed in claim 35 wherein said isonitrile ligand is n-propyl or iso-propyl isonitrile.
Claim 42
Dependent Claim
14 words
A kit as claimed in claim 35 wherein said isonitrile ligand is cyclohexyl isonitrile.
Claim 43
Independent Claim
95 words
A method for preparing a technetium complex of an isonitrile ligand for radiographic imaging, said method comprising preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal-isonitrile salt with a salt comprising said technetium in the presence of a reducing agent to displace the displaceable metal with reduced technetium, thereby forming said technetium-isonitrile complex.
Claim 44
Independent Claim
95 words
A method for preparing a technetium complex of an isonitrile ligand for radiographic imaging, said method comprising preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal-isonitrile salt with a salt comprising said technetium in the presence of a reducing agent to displace the displaceable metal with reduced technetium, thereby forming said technetium-isonitrile complex.
Claim 45
Dependent Claim
25 words
The method of claim 1 wherein said displaceable metal is selected from the class consisting of Zn, Ga, Cd, In, Hg, Tl, Pb and Bi.
Claim 46
Dependent Claim
11 words
The method of claim 41 wherein said displaceable metal is zinc.
Claim 47
Dependent Claim
11 words
The method of claim 43 wherein said isonitrile ligand is aliphatic.
Claim 48
Dependent Claim
13 words
The method of claim 43 wherein said isonitrile ligand is a hydrocarbon isonitrile.
Claim 49
Dependent Claim
14 words
The method of claim 43 wherein said isonitrile ligand is a saturated hydrocarbon isonitrile.
Claim 50
Dependent Claim
13 words
The method of claim 43 wherein said isonitrile ligand is a monodentate ligand.
Claim 51
Dependent Claim
13 words
The method of claim 43 wherein said isonitrile ligand is a bidentate ligand.
Claim 52
Dependent Claim
13 words
The method of claim 43 wherein said isonitrile ligand is a polydentate ligand.
Claim 53
Dependent Claim
11 words
The method of claim 43 wherein said radioactive metal is Tc-99m.
Claim 54
Dependent Claim
13 words
The method of claim 50 wherein said isonitrile ligand is a butyl isonitrile.
Claim 55
Dependent Claim
13 words
The method of claim 50 wherein said isonitrile ligand is tertiary butyl isonitrile.
Claim 56
Dependent Claim
14 words
The method of claim 50 wherein said isonitrile ligand is n-butyl or sec-butyl isonitrile.
Claim 57
Dependent Claim
14 words
The method of claim 50 wherein said isonitrile ligand is n-propyl or isopropyl isonitrile.
Claim 58
Dependent Claim
12 words
The method of claim 50 wherein said isonitrile ligand is cyclohexyl isonitrile.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-16 | 1991-05-18 | 1991-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-16 | 1995-05-18 | 1995-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-16 | 1999-05-18 | 1999-11-17 | $7700.00 | Window Closed / Lapsed |