US4917688A — Bandage for transdermal delivery of systemically-…

Claim 1

Independent Claim 84 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a fixed supply of an active agent; a control means, separate from said fixed supply of active agent, for adjustably and incrementally controlling surface contact area between the fixed supply of active agent and the dermal surface when the bandage is held thereagainst in order to select one of a plurality of available doses greater than zero that can be delivered by the bandage without altering the fixed supply of active agent.

Claim 2

Dependent Claim 84 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a fixed supply of an active agent; a control means, separate from said fixed supply of active agent, for adjustably and incrementally controlling surface contact area between the fixed supply of active agent and the dermal surface when the bandage is held thereagainst in order to select one of a plurality of available doses greater than zero that can be delivered by the bandage without altering the fixed supply of active agent.

Claim 3

Dependent Claim 38 words

The bandage, in accordance with claim 1 wherein said control means includes manual means operable by a user of said bandage for adjustably controlling surface contact area between the fixed supply of active agent and the dermal surface.

Claim 4

Dependent Claim 26 words

The bandage in accordance with claim 2 wherein said manual means includes at least two selectably removable cover segments disposed over said supply of active agent.

Claim 5

Dependent Claim 127 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a supply of active agent; and control means, separate from said supply of active agent, for adjustably controlling surface contact area between the active agent and the dermal surface when the bandage is held thereagainst, said control means including manual means comprising a plurality of selectably removable cover segments, said plurality of selectably removable cover segments together forming a cover sheet, said cover sheet completely covering said supply of active agent, said selectably removable cover segments being defined by perforations in said cover sheet, said perforations enabling manual separation of one or more of the removable cover segments from the cover sheet to control surface contact area between the active agent and the dermal surface.

Claim 6

Dependent Claim 127 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a supply of active agent; and control means, separate from said supply of active agent, for adjustably controlling surface contact area between the active agent and the dermal surface when the bandage is held thereagainst, said control means including manual means comprising a plurality of selectably removable cover segments, said plurality of selectably removable cover segments together forming a cover sheet, said cover sheet completely covering said supply of active agent, said selectably removable cover segments being defined by perforations in said cover sheet, said perforations enabling manual separation of one or more of the removable cover segments from the cover sheet to control surface contact area between the active agent and the dermal surface.

Claim 7

Dependent Claim 33 words

The bandage, in accordance with claim 4 wherein the supply of active agent comprises a microporous material containing said active agent, said microporous material being permeable to the passage of said active agent.

Claim 8

Dependent Claim 38 words

The bandage, in accordance with claim 4 wherein the supply of active agent comprises a liquid or gel containing the active agent separated from said cover sheet by a membrane permeable to the passage of the active agent.

Claim 9

Dependent Claim 19 words

The bandage, in accordance with claim 4, wherein said perforations define a set of cover segments having differing sizes.

Claim 10

Dependent Claim 54 words

The bandage, in accordance with claim 4, wherein said plurality of selectably removable cover segments comprise a set of elongated strips disposed in a parallel relationship over said supply of active agent, each strip having tab means thereon for manually separating each strip from the cover sheet and the fixed supply of active agent.

Claim 11

Dependent Claim 47 words

The bandage, in accordance with claim 8, further comprising indicia means, associated within each cover segment, for displaying the dosage of active agent delivered into the dermal surface when the bandage is secured in an operational position on the dermal surface with a preselected cover segment removed.

Claim 12

Dependent Claim 24 words

The bandage in accordance with claim 9 wherein the indicia means comprises a plurality of distinguishable colors, each tab means having a different color.

Claim 13

Dependent Claim 98 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a fixed supply of active agent; adhesive means for releasably securing the bandage to a dermal surface; and control means, separate from said fixed supply of active agent, for adjustably and incrementally controlling the amount of migration of the active agent into the dermal surface to provide one of a plurality of available doses greater than zero without altering the fixed supply of active agent, said control means including means for controlling surface contact area between the fixed supply of active agent and the dermal surface.

Claim 14

Dependent Claim 98 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a fixed supply of active agent; adhesive means for releasably securing the bandage to a dermal surface; and control means, separate from said fixed supply of active agent, for adjustably and incrementally controlling the amount of migration of the active agent into the dermal surface to provide one of a plurality of available doses greater than zero without altering the fixed supply of active agent, said control means including means for controlling surface contact area between the fixed supply of active agent and the dermal surface.

Claim 15

Dependent Claim 32 words

The bandage, in accordance with claim 11, further comprising a backing sheet and said fixed supply of active agent and said adhesive means is disposed on one side of said backing sheet.

Claim 16

Dependent Claim 62 words

The bandage, in accordance with claim 12, wherein said adhesive means is disposed on said backing sheet in a spaced-apart relationship with said fixed supply of active agent for securing the bandage to a dermal surface in an operational relationship permitting the control means to adjustably control migration of the active agent into the dermal surface without contact with the adhesive means.

Claim 17

Dependent Claim 92 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a fixed supply of active agent; adhesive means for releasably securing the bandage to a dermal surface; control means, separate from said fixed supply of active agent, for adjustably controlling surface contact between the fixed supply of active agent and the dermal surface in multiple increments greater than zero; and means for enabling preselective limiting of the operation of the control means to providing a preselected maximum surface contact between the fixed supply of active agent and the dermal surface.

Claim 18

Dependent Claim 92 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a fixed supply of active agent; adhesive means for releasably securing the bandage to a dermal surface; control means, separate from said fixed supply of active agent, for adjustably controlling surface contact between the fixed supply of active agent and the dermal surface in multiple increments greater than zero; and means for enabling preselective limiting of the operation of the control means to providing a preselected maximum surface contact between the fixed supply of active agent and the dermal surface.

Claim 19

Dependent Claim 32 words

The bandage, in accordance with claim 14, wherein said control means includes means, operable by a user of said bandage, for controlling surface contact area between the fixed supply of active agent.

Claim 20

Dependent Claim 27 words

The bandage, in accordance with claim 15, wherein said manual means includes at least two selectably removable cover segments disposed over said fixed supply of active agent.

Claim 21

Dependent Claim 68 words

A bandage for transdermal delivery of an active agent, said bandage comprising: manual means comprising a plurality of selectably removable cover segments, said cover segments together forming a cover sheet, said cover sheet completely covering said supply of active agent, said selectably removable cover segments being of the removable cover segments from the cover sheet to control surface contact area between the active agent and the dermal surface.

Claim 22

Dependent Claim 68 words

A bandage for transdermal delivery of an active agent, said bandage comprising: manual means comprising a plurality of selectably removable cover segments, said cover segments together forming a cover sheet, said cover sheet completely covering said supply of active agent, said selectably removable cover segments being of the removable cover segments from the cover sheet to control surface contact area between the active agent and the dermal surface.

Claim 23

Dependent Claim 32 words

The bandage, in accordance with claim 17 wherein said plurality of selectably removable cover segment comprises a set of elongated strips disposed in a parallel relationship over said supply of active agent.

Claim 24

Dependent Claim 62 words

The bandage in accordance with claim 18 when said means for enabling preselective limiting of the operation of the control means comprises a plurality of severable tabs, each one of the plurality of severable tabs being attached to a corresponding cover segment, each said tab having a length sufficient to extend beyond a periphery of the bandage to enable preselective severing thereof.

Claim 25

Dependent Claim 46 words

The bandage, in accordance with claim 19, further comprising a backing sheet having the supply of active agent disposed along a central portion thereof and the adhesive means disposed along the periphery of the backing sheet and a releasable protection sheet disposed over said adhesive means.

Claim 26

Dependent Claim 89 words

The bandage in accordance with claim 20 wherein each of said severable tabs comprises end portion means, extending beyond the backing sheet, for enabling manual grasping thereof for separating each corresponding tab from the backing sheet and corresponding cover segment from the cover sheet along the perforations therein, said adhesive means including tab adhesive means disposed under each tab, for preventing separation of a severable tab from the backing sheet, and corresponding cover segment from the cover sheet, when the end portion means is removed from the severable tab.

Claim 27

Dependent Claim 110 words

A bandage system for providing multiple doses of an active agent in selectively equal or differing amounts, said bandage system comprising: a plurality for individual bandage means of transdermal delivery of the active agent, each said individual bandage means comprising an active agent, adhesive means for releasably securing the individual bandage means to a dermal surface and control means, separate from said supply of active agent, for adjustably and incrementally controlling surface contact area between the active agent and the dermal surface when the individual bandage is secured in an operational position on the dermal surface in order to provide one of a plurality of available doses greater than zero.

Claim 28

Dependent Claim 110 words

A bandage system for providing multiple doses of an active agent in selectively equal or differing amounts, said bandage system comprising: a plurality for individual bandage means of transdermal delivery of the active agent, each said individual bandage means comprising an active agent, adhesive means for releasably securing the individual bandage means to a dermal surface and control means, separate from said supply of active agent, for adjustably and incrementally controlling surface contact area between the active agent and the dermal surface when the individual bandage is secured in an operational position on the dermal surface in order to provide one of a plurality of available doses greater than zero.

Claim 29

Dependent Claim 41 words

The bandage system, in accordance with claim 22, wherein said control means of each individual bandage includes manual means operable by a user of said individual bandage for adjustably controlling surface contact area between the active agent and the dermal surface.

Claim 30

Dependent Claim 152 words

A bandage system for providing multiple doses of an active agent in selectively equal or different amounts, said bandage system comprising: a plurality of individual bandage means for transdermal delivery of the active agent, each said individual bandage means comprising a supply of the active drug, adhesive means for releasably securing the individual bandage means to a dermal surface and control means, separate from said supply of active agent, for adjustably controlling surface contact between the active agent and the dermal surface when the individual bandage is secured in an operational position on the dermal surface, said control means of each bandage means including manual means, operable by a use of said individual bandage, for adjustably controlling surface contact area between the active agent and the dermal surface, each said manual means including a plurality of selectably removable cover segments disposed over said supply of active agent on each individual bandage means.

Claim 31

Dependent Claim 152 words

A bandage system for providing multiple doses of an active agent in selectively equal or different amounts, said bandage system comprising: a plurality of individual bandage means for transdermal delivery of the active agent, each said individual bandage means comprising a supply of the active drug, adhesive means for releasably securing the individual bandage means to a dermal surface and control means, separate from said supply of active agent, for adjustably controlling surface contact between the active agent and the dermal surface when the individual bandage is secured in an operational position on the dermal surface, said control means of each bandage means including manual means, operable by a use of said individual bandage, for adjustably controlling surface contact area between the active agent and the dermal surface, each said manual means including a plurality of selectably removable cover segments disposed over said supply of active agent on each individual bandage means.

Claim 32

Dependent Claim 107 words

The bandage system in accordance with claim 24 wherein said plurality of selectably removable cover segments on each individual bandage together forms an associated cover sheet on each individual bandage, each said associated cover sheet completely covering said supply of active agent on each individual bandage, said selectably removable cover segment being defined by perforations in each said associated cover sheet, said perforations enabling manual separation of one or more of the removable cover segments from the associated cover sheet to control surface contact area between the active agent and the dermal surface when each individual bandage is placed in an operational relationship with the dermal surface.

Claim 33

Dependent Claim 52 words

The bandage system in accordance with claim 22 further comprising indicia means associated with each cover segment on each individual bandage for displaying the dosage of active agent delivered into the dermal surface when each bandage is secured in an operational position on the dermal surface with a preselected cover segment removed.

Claim 34

Dependent Claim 41 words

The bandage systems in accordance with claim 26 wherein the indicia means comprises a plurality of distinguishable colors, each cover segment of each individual bandage having a different color and each cover segment of the same size having the same color.

Claim 35

Dependent Claim 81 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a supply of an active agent; and control means, separate from said supply of active agent for adjustably controlling surface contact area between the active agent and the dermal surface when the bandage is held thereagainst, said control means including manual means comprising selectably removable cover segments, a plurality of said selectably removable cover segments forming a cover sheet, said cover sheet completely covering said supply of active agent.

Claim 36

Dependent Claim 81 words

A bandage for transdermal delivery of an active agent, said bandage comprising: a supply of an active agent; and control means, separate from said supply of active agent for adjustably controlling surface contact area between the active agent and the dermal surface when the bandage is held thereagainst, said control means including manual means comprising selectably removable cover segments, a plurality of said selectably removable cover segments forming a cover sheet, said cover sheet completely covering said supply of active agent.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-04-16	1993-10-16	1994-04-17	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-04-16	1997-10-16	1998-04-17	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-04-16	2001-10-16	2002-04-17	$7700.00	Window Closed / Lapsed

Bandage for transdermal delivery of systemically-active drug

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