Patent US4910203A successfully refreshed from Google Patents.
US4910203A
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Pteridine compounds
Assignee: VOELGER KARL DIETER
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Filing: 1988-04-20
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Granted: 1990-03-20
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Expires: 2008-04-20
Abstract
Abstract Pteridine compounds, useful as diuretics, of the formula ##STR1## wherein R 1 and R 2 taken alone are, independently of each other, hydrogen, alkyl having from 1 to 6 carbon atoms, or benzyl, or wherein R 1 and R 2 , taken together with the nitrogen atom to which they are bound, form a five- or six-membered heterocyclic ring system or such a ring containing one or two further hetero atoms, or wherein R 1 and R 2 together with the nitrogen are ##STR2##
Inventors
- 👤 Christian Rietzel
- 👤 Heinrich Knauf
- 👤 Ernst Mutschler
- 👤 Karl-Dieter Voelger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 05:20
CPC Classifications
C; C07; C07C; C07C255/00; A; A61; A61P; A61P7/00; A61P7/10; A61P9/00; A61P9/12; C07D; C07D475/00; C07D475/06; C07D475/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
82 words
A pteridine compound of the formula ##STR22## or a pharmaceutically acceptable acid addition salt thereof, wherein one of R 1 or R 2 is benzyl and the other is hydrogen, alkyl having from 1 to 6 carbon atoms, or benzyl, or wherein R 1 and R 2 , taken together with the nitrogen atom to which they are bound, form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, or N'-alkyl piperazinyl group, or wherein R 1 and R 2 together with the nitrogen are ##STR23##
Claim 2
Dependent Claim
82 words
A pteridine compound of the formula ##STR22## or a pharmaceutically acceptable acid addition salt thereof, wherein one of R 1 or R 2 is benzyl and the other is hydrogen, alkyl having from 1 to 6 carbon atoms, or benzyl, or wherein R 1 and R 2 , taken together with the nitrogen atom to which they are bound, form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, or N'-alkyl piperazinyl group, or wherein R 1 and R 2 together with the nitrogen are ##STR23##
Claim 3
Dependent Claim
15 words
A compound as in claim 1 which is 2,4,7-triamino-6-[4-[2-hydroxy-3-(morpholin-4-yl)-propoxy]-phenyl]-pteridine or an acid addition salt thereof.
Claim 4
Dependent Claim
15 words
A compound as in claim 1 which is 2,4,7-triamino-6-[4-[2-hydroxy-3-(piperidin-1-yl)-propoxy]-phenyl]-pteridine or an acid addition salt thereof.
Claim 5
Dependent Claim
15 words
A compound as in claim 1 which is 2,4,7-triamino-6-[4-[2-hydroxy-3(pyrrolidin-1-yl)-propoxy]-phenyl-]-pteridine or an acid addition salt thereof.
Claim 6
Dependent Claim
15 words
A compound as in claim 1 which is 2,4,7-triamino-6-[4-[2-hydroxy-3(4-methyl-piperazin-1-yl)propoxy]-phenyl]-pteridine or an acid addition salt thereof.
Claim 7
Dependent Claim
15 words
A compound as in claim 1 which is 2,4,7-triamino-6-[4-(2-hydroxy-3-benzylaminopropoxy)-phenyl]pteridine or an acid addition salt thereof.
Claim 8
Dependent Claim
19 words
A diuretic-antikaluretic-antihypertensive pharmaceutical preparation comprising a compound or salt as in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 9
Dependent Claim
20 words
A pharmaceutical preparation as in claim 7 comprising a daily dose from 0.2 to 100 mg of the active substance.
Claim 10
Dependent Claim
31 words
A diuretic-antikaluretic-antihypertensive pharmaceutical composition in dosage unit form for oral administration comprising an effective amount of a compound or salt as in claim 1 and an orally ingestible pharmaceutical excipient therefor.
Claim 11
Dependent Claim
30 words
A diuretic-antikaluretic-antihypertensive pharmaceutical composition in dosage unit form for parenteral administration comprising an effective amount of a compound or salt as in claim 1 and an injectable pharmaceutical excipient therefor.
Claim 12
Dependent Claim
31 words
A method for inducing diuresis in a patient, which method comprises orally or parenterally administering to said patient a diuretically effective amount of a compound or salt as in claim 1.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-19 | 1993-09-18 | 1994-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-19 | 1997-09-18 | 1998-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-19 | 2001-09-18 | 2002-03-20 | $7700.00 | Window Closed / Lapsed |