Patent US4904699A successfully refreshed from Google Patents.
US4904699A
Expired / Lapsed
US
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Nifedipine concentrate stabilized against the influence of light and a process for its preparation
Assignee: Individual
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Filing: 1987-12-07
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Granted: 1990-02-27
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Expires: 2007-12-07
Abstract
Abstract A nifedipine concentrate stabilized against the influence of light is described, characterized in that it contains nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B 2 , based on the nifedipine, at least one surface-active agent and optionally conventional carriers. A process for the preparation of the nifedipine concentrate and a medicament containing nifedipine and its use for the production of pharmaceutical preparations are also described.
Inventors
- 👤 Kurt H. Bauer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:15
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/22; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K9/00; A61K9/14; A61K9/141; A61K9/146
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
33 words
Nifedipine concentrate stabilized against the influence of light, comprising nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B 2 , based on the nifedipine, and at least one surface-active agent.
Claim 2
Dependent Claim
33 words
Nifedipine concentrate stabilized against the influence of light, comprising nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B 2 , based on the nifedipine, and at least one surface-active agent.
Claim 3
Dependent Claim
23 words
Nifedipine concentrate according to claim 1, wherein the ratio of nifedipine to polyethylene glycol is in the range of from 2:1 to 1:3.
Claim 4
Dependent Claim
23 words
Nifedipine concentrate according to claim 1 or 2, containing from 2 to 50 parts of surface-active agent, based on 50 parts of nifedipine.
Claim 5
Dependent Claim
42 words
Nifedipine concentrate according to claim 1 or 2, wherein said at least one surface-active agent is selected from the group consisting of ethoxy-propoxy copolymers, polyoxyethylene fatty acid esters, polyethylene fatty alcohol ethers, ethoxylated, hydrogenated castor oil products and mixtures of these compounds.
Claim 6
Dependent Claim
11 words
Nifedipine concentrate according to claim 1 containing additionally a conventional carrier.
Claim 7
Dependent Claim
88 words
A process for the preparation of a nifedipine concentrate stabilized against the influence of light, comprising: (a) dissolving nifedipine and polyethylene glycol in an organic solvent to form a solution, (b) adding to the solution of (a) an aqueous solution or suspension of Vitamin B 2 , at least one of the solution of (a) or said aqueous solution or suspension of Vitamin B 2 also containing surface-active agent, (c) mixing the result of (b), (d) concentrating by evaporation the result of (c) to isolate a stabilized product.
Claim 8
Dependent Claim
88 words
A process for the preparation of a nifedipine concentrate stabilized against the influence of light, comprising: (a) dissolving nifedipine and polyethylene glycol in an organic solvent to form a solution, (b) adding to the solution of (a) an aqueous solution or suspension of Vitamin B 2 , at least one of the solution of (a) or said aqueous solution or suspension of Vitamin B 2 also containing surface-active agent, (c) mixing the result of (b), (d) concentrating by evaporation the result of (c) to isolate a stabilized product.
Claim 9
Dependent Claim
22 words
Process according to claim 6 wherein the organic solvent used is selected from the group consisting of acetone, chlorinated hydrocarbons and toluene.
Claim 10
Dependent Claim
43 words
Process according to claim 6 or 7, wherein nifedipine and the polyethylene glycol are used in a ratio of from 2:1 to 1:1 and wherein from 0.5% to 20% by weight of Vitamin B 2 is used, based on the quantity of nifedipine.
Claim 11
Dependent Claim
28 words
Process according to one of the claims 6 or 7 wherein the surface-active agent is used in a quantity from 2 to 50 parts, based on the nifedipine.
Claim 12
Dependent Claim
14 words
Process according to claim 6 wherein the dissolving in (a) is accomplished with heating.
Claim 13
Dependent Claim
13 words
Process according to claim 6 additionally comprising (e) granulating the product of (d).
Claim 14
Dependent Claim
28 words
Medicament comprising nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B 2 , based on the nifedipine, at least one surface-active agent and pharmaceutical carriers.
Claim 15
Dependent Claim
28 words
Medicament comprising nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B 2 , based on the nifedipine, at least one surface-active agent and pharmaceutical carriers.
Claim 16
Dependent Claim
22 words
Medicament according to claim 12 wherein the ratio of nifedipine to polyethylene glycol is in the range of from 2:1 to 1:3.
Claim 17
Dependent Claim
25 words
Medicament according to one of the claims 12 or 13, containing from 2 to 50 parts of surface-active agent, based on 50 parts of nifedipine.
Claim 18
Dependent Claim
41 words
Medicament according to claims 12 or 13 wherein the at least one surface-active agent is selected from the group consisting of ethoxy-propoxy copolymers, polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, ethoxylated, hydrogenated castor oil products and mixtures of these compounds.
Claim 19
Dependent Claim
9 words
Medicament according to claim 12 additionally comprising a diluent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-26 | 1993-08-28 | 1994-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-26 | 1997-08-28 | 1998-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-26 | 2001-08-28 | 2002-02-27 | $7700.00 | Window Closed / Lapsed |