US4897412A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Imidazolines useful in lowering intraocular pressure
Assignee: Laboratoires Alcon SAS
•
Filing: 1989-01-19
•
Granted: 1990-01-30
•
Expires: 2009-01-19
Abstract
Abstract Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.
Inventors
- 👤 Gerard LeClerc
- 👤 Didier Huber
- 👤 Jacques Himber
- 👤 Guy Andermann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:27
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/20; C07D233/22; C07D233/28; C07D233/44; C07D233/50
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
8 words
A compound formula: ##STR9## wherein R is ##STR10##
Claim 2
Dependent Claim
8 words
A compound formula: ##STR9## wherein R is ##STR10##
Claim 3
Dependent Claim
32 words
A topical ophthalmic composition useful in the treatment of elevated intraoccular pressure, comprising an effective amount of a compound of formula: ##STR11## wherein R is ##STR12## and a pharmaceutically acceptable carrier therefor.
Claim 4
Dependent Claim
32 words
A topical ophthalmic composition useful in the treatment of elevated intraoccular pressure, comprising an effective amount of a compound of formula: ##STR11## wherein R is ##STR12## and a pharmaceutically acceptable carrier therefor.
Claim 5
Dependent Claim
21 words
A method of lowering intraocular pressure which comprises applying an ophthalmic composition according to claim 2 topically to the affected eye.
References Cited (Backward Citations)
US4195085A
Cited
US4342783A
Cited
US4450170A
Cited
US4461904A
Cited
US4515800A
Cited
US4517199A
Cited
US4444782A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-29 | 1993-07-31 | 1994-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-29 | 1997-07-31 | 1998-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-29 | 2001-07-31 | 2002-01-30 | $7700.00 | Window Closed / Lapsed |