US4450170A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of diarrhoea with 2-aminoimidazoline derivatives
Assignee: Beecham Group PLC
•
Filing: 1981-06-24
•
Granted: 1984-05-22
•
Expires: 2001-06-24
Abstract
Abstract Compounds A - B - C wherein A is 2 imidazolinyl or N-alkyl derivative thereof, B is oxygen, sulphur, CR1R2 wherein R1 and R2 are hydrogen or alkyl, or NR3 wherein R3 is hydrogen or alkyl, and C is a 5 - or 6 - membered carbo- or heterocyclic group having a nitrogen containing substituent and up to two other substituents, are useful in treatment of diarrhoea or scours. Certain compounds A - B - C are novel.
Inventors
- 👤 Lee J. Beeley
- 👤 Peter M. Newsome
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61K31/429; A61K31/43; A61P; A61P1/00; A61P1/12; C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
44 words
A pharmaceutical composition for the treatment of diarrhoea in animals including man, comprising an effective, non-toxic amount of p-amino clonidine or a pharmaceutically acceptable N-carboxylic acid acyl derivative thereof and/or a pharmaceutically acceptable acid addition salt thereof in combination with an oral rehydration formula.
Claim 2
Dependent Claim
44 words
A pharmaceutical composition for the treatment of diarrhoea in animals including man, comprising an effective, non-toxic amount of p-amino clonidine or a pharmaceutically acceptable N-carboxylic acid acyl derivative thereof and/or a pharmaceutically acceptable acid addition salt thereof in combination with an oral rehydration formula.
Claim 3
Dependent Claim
42 words
A mehthod for treating diarrhoea in animals including man, which comprises administering an effective, non-toxic amount of p-amino clonidine or a pharmaceutically acceptable N-carboxylic acid acyl derivative and/or pharmaceutically acceptable acid addition salt thereof, to an animal, including man, suffering from diarrhoea.
Claim 4
Dependent Claim
42 words
A mehthod for treating diarrhoea in animals including man, which comprises administering an effective, non-toxic amount of p-amino clonidine or a pharmaceutically acceptable N-carboxylic acid acyl derivative and/or pharmaceutically acceptable acid addition salt thereof, to an animal, including man, suffering from diarrhoea.
Claim 5
Dependent Claim
19 words
The method according to claim 2, wherein p-amino clonidine or a pharmaceutically acceptable acid addition salt thereof is administered.
Claim 6
Independent Claim
118 words
A method for treating diarrhoea in animals including man, which comprises administering an effective, non-toxic amount of a compound of formula (I): A--B--C (I) wherein A is 2-imidazolinyl optionally substituted on a nitrogen atom with C 1-4 alkyl; B is NR 3 , where R 3 is C 1-4 alkyl or hydrogen; and C is phenyl being substituted by unsubstituted guanidino or guanidino substituted by one or more C 1-4 alkyl; said phenyl being optionally substituted by one or two groups, each selected from halogen, (C 1-4 ) alkyl, (C 1-4 ) alkoxy and hydroxy; or a pharmaceutically acceptable N-carboxylic acid acyl derivative and/or pharmaceutically acceptable acid addition salt thereof, to an animal, including man, suffering from diarrhoea.
Claim 7
Independent Claim
118 words
A method for treating diarrhoea in animals including man, which comprises administering an effective, non-toxic amount of a compound of formula (I): A--B--C (I) wherein A is 2-imidazolinyl optionally substituted on a nitrogen atom with C 1-4 alkyl; B is NR 3 , where R 3 is C 1-4 alkyl or hydrogen; and C is phenyl being substituted by unsubstituted guanidino or guanidino substituted by one or more C 1-4 alkyl; said phenyl being optionally substituted by one or two groups, each selected from halogen, (C 1-4 ) alkyl, (C 1-4 ) alkoxy and hydroxy; or a pharmaceutically acceptable N-carboxylic acid acyl derivative and/or pharmaceutically acceptable acid addition salt thereof, to an animal, including man, suffering from diarrhoea.
Claim 8
Dependent Claim
36 words
The method according to claim 4, wherein C is phenyl substituted by unsubstituted guanidino and optionally substituted by one or two groups, each selected from halogen, (C 1-4 ) alkyl, (C 1-4 ) alkoxy and hydroxy.
Claim 9
Dependent Claim
38 words
The method according to claim 4, wherein C is phenyl substituted by di(C 1-4 ) alkylguanidino and optionally substituted by one or two groups, each selected from halogen, (C 1-4 ) alkyl, (C 1-4 ) alkoxy and hydroxy.
Claim 10
Dependent Claim
49 words
A pharmaceutical composition for the treatment of diarrhoea in animals including man, comprising an effective, non-toxic amount of a compound as defined in claim 4 or a pharmaceutically acceptable N-carboxylic acid acyl derivative thereof and/or a pharmaceutically acceptable acid addition salt thereof in combination with an oral rehydration formulation.
References Cited (Backward Citations)
US3190802A
Cited
DE1670274A1
Cited
DE1929950A1
Cited
DE2806811A1
Cited
GB2014575A
Cited
US4332814A
Cited
US4265900A
Cited
US4312879A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-22 | 1987-11-21 | 1988-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-22 | 1991-11-21 | 1992-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-22 | 1995-11-21 | 1996-05-22 | $7700.00 | Window Closed / Lapsed |