US4312879A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Clonidine and lofexidine as antidiarrheal agents
Assignee: Richardson Vicks Inc
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Filing: 1980-08-14
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Granted: 1982-01-26
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Expires: 2000-08-14
Abstract
Abstract Clonidine and lofexidine and the pharmaceutically acceptable salts thereof, which are, inter alia, known antihypertensives, also possess very potent antidiarrheal activity which is non-narcotic and more potent than that of conventional antidiarrheal drugs, such as diphenoxylate.
Inventors
- 👤 Harbans Lal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:55
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50; C07D233/06; C07D233/08; C07D233/12; C07D233/14
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
73 words
A method of alleviating the symptoms of diarrhea induced by a toxin, antigen, a general irritant or by the administration of an antibiotic, but excluding diarrhea induced by central nervious system disorders, in a patient not otherwise being treated with clonidine, lofexidine or an antihypertensive drug, comprising administering to such a patient an antidiarrheally-effective, non-antihypertensive amount of clonidine, lofexidine or a pharmaceutically acceptable salt thereof for a period of up to 4 days.
Claim 2
Independent Claim
73 words
A method of alleviating the symptoms of diarrhea induced by a toxin, antigen, a general irritant or by the administration of an antibiotic, but excluding diarrhea induced by central nervious system disorders, in a patient not otherwise being treated with clonidine, lofexidine or an antihypertensive drug, comprising administering to such a patient an antidiarrheally-effective, non-antihypertensive amount of clonidine, lofexidine or a pharmaceutically acceptable salt thereof for a period of up to 4 days.
Claim 3
Dependent Claim
12 words
The method of claim 1, wherein clonidine is administered to the patient.
Claim 4
Dependent Claim
12 words
The method of claim 1, wherein lofexidine is administered to the patient.
Claim 5
Dependent Claim
13 words
The method of claim 2, wherein clonidine is administered as its hydrochloride salt.
Claim 6
Dependent Claim
13 words
The method of claim 3, wherein lofexidine is administered as its hydrochloride salt.
Claim 7
Dependent Claim
15 words
The method of claim 2, wherein the dosage of clonidine is 0.1-0.4 mg per day.
Claim 8
Dependent Claim
15 words
The method of claim 3, wherein the dosage of lofexidine is 0.1-0.4 mg per day.
Claim 9
Dependent Claim
10 words
The method of claim 1, wherein the administration is oral.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-01-25 | 1985-07-27 | 1986-01-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-01-25 | 1989-07-27 | 1990-01-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-01-25 | 1993-07-27 | 1994-01-26 | $7700.00 | Window Closed / Lapsed |