Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties

Claim 1

A compound of Formula XXI" ##STR27## and the pharmaceutically acceptable acid addition salts thereof wherein R 2 and R 6 are independently selected from lower alkyl, hydroxy-lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkylamino-lower-alkyl, or di-lower alkylamino-lower-alkyl; R 4 is cycloalkyl of 5-7 carbons, bicycloalkenyl of 7-9 carbon atoms, furanyl, indolyl, methylthiopyridyl, thienyl, benzoxadiazolyl, and benzothiadiazolyl; phenyl, naphthyl, or substituted phenyl, with a substituent selected from the group consisting of acetamino, lower alkyl, lower alkoxy, cyano, halogen, hydroxyl, nitro, trifluoromethyl, trifluooromethylsulfonyl, and methylsulfonyl; R 5 is R 2 or ##STR28## X is O; Y is a C 2 to C 5 alkylene chain, alkyleneoxyalkylene, alkylenethioalkylene, or alkyleneaminoalkylene chain wherein each alkylene moiety has 2-5 carbon atoms with the proviso that when R 5 is R 2 , Y cannot be C 2 to C 5 alkylene chain; and Z is phenyl, pyridinyl, or pyrimidinyl, either unsubstituted or substituted with a group selected from among lower alkyl, lower alkoxy, cyano, halo, and trifluoromethyl.