Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
221 words
A 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative of the general formula: or a pharmaceutically acceptable acid addition salt thereof, wherein W is -CH= or -N=; Y is -CH=CH-, -O-, -S-, -CH=H(O)p- (p is zero or 1) or -N(R)- (R is hydrogen or lower alkyl); X 1 , X 2 and X 3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkyl; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent aromatic heterocyclic ring (which may have a substituent or two or three substituents which are the same or different, and the substituent may be halogen, lower alkyl lower alkoxy, lower alkancylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkylsulfamoyl, amino or di-lower alkylamino); is 5- to 7-membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring oxygen atom, sulfur atom or unsaturated bond on the ring and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or -(CH 2 ) m -OR 4 (R 4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2) R 1 and R 2 are the same or different and are each lower alkyl; R 3 is lower alkyl, aralkyl or heteroaralkyl; and n is an integer 1 to 5.
Claim 2
Dependent Claim
221 words
A 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative of the general formula: or a pharmaceutically acceptable acid addition salt thereof, wherein W is -CH= or -N=; Y is -CH=CH-, -O-, -S-, -CH=H(O)p- (p is zero or 1) or -N(R)- (R is hydrogen or lower alkyl); X 1 , X 2 and X 3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkyl; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent aromatic heterocyclic ring (which may have a substituent or two or three substituents which are the same or different, and the substituent may be halogen, lower alkyl lower alkoxy, lower alkancylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkylsulfamoyl, amino or di-lower alkylamino); is 5- to 7-membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring oxygen atom, sulfur atom or unsaturated bond on the ring and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or -(CH 2 ) m -OR 4 (R 4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2) R 1 and R 2 are the same or different and are each lower alkyl; R 3 is lower alkyl, aralkyl or heteroaralkyl; and n is an integer 1 to 5.
Claim 3
Dependent Claim
7 words
The-compound of Claim 1: 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3- methylester-5-(1-phenyl-2-piperidinoethyl)ester.
Claim 4
Dependent Claim
7 words
The compound of Claim 1: 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5-[1-(2-thienyl)-2-piperidinoethyl]ester.
Claim 5
Dependent Claim
7 words
The compound of Claim 1: 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5-[1-(2-furyl)-2-piperidinoethyl]ester.
Claim 6
Dependent Claim
8 words
The conpound of Claim 1: 2,6-dimethyl-4-(2-thienyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5- (1-phenyl-2-piperidinoethyl)ester.
Claim 7
Dependent Claim
8 words
The conpound of Claim 1: 2,6-dimethyl-4-(2-furyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5- (1-phenyl-2-piperidinoethyl)ester.
Claim 8
Dependent Claim
9 words
The compound of Claim 1: 2,6-dimethyl-4-(2-furyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5- [2-piperidine-1-(2-thienyl)ethyl] ester.
Claim 9
Dependent Claim
7 words
The compound of Claim 1: 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5-(2-morpholino-1-phenylethyl)ester.
Claim 10
Dependent Claim
7 words
The conpound of Claim 1: 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5-[1-phenyl-2-(1-pyrrolidinyl)ethyl]ester.
Claim 11
Dependent Claim
26 words
A pharmaceutical composition comprising the compound of Claim 1 in combination with a pharmaceutically acceptable inert carrier, said compound being present in a therapeutically effective amount.