US4393070A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dihydropyridine derivative, and pharmaceutical composition comprising the same
Assignee: Astellas Pharma Inc
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Filing: 1980-12-04
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Granted: 1983-07-12
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Expires: 2000-12-04
Abstract
Abstract 1,4-dihydropyridine derivatives of the general formula: <IMAGE> having vasodilating and anti-hypertensive activity, processes for preparing same, and pharmaceutical compositions thereof for treating cardiovascular diseases.
Inventors
- 👤 Yoshinari Sato
- 👤 Tsutomu Teraji
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:54
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12; A; A61; A61P; A61P9/00; A61P9/08; A61P9/10; A61P9/12; C07C; C07C323/00; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
43 words
A compound of the formula: ##STR17## wherein R 1 is cyano or trifluoromethyl, R 2 is [N-lower alkyl-N-mono- or dihalophenyl(lower)alkyl]amino(lower)alkyl; R 3 and R 4 are each lower alkyl, and R 5 is formyl, di(lower) alkoxymethyl or hydroxymethyl, and pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
43 words
A compound of the formula: ##STR17## wherein R 1 is cyano or trifluoromethyl, R 2 is [N-lower alkyl-N-mono- or dihalophenyl(lower)alkyl]amino(lower)alkyl; R 3 and R 4 are each lower alkyl, and R 5 is formyl, di(lower) alkoxymethyl or hydroxymethyl, and pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
39 words
A compound according to claim 1, wherein R 1 is cyano or trifluoromethyl, R 2 is [N-lower alkyl-N-mono- or dihalophenyl(lower)alkyl]amino(lower)alkyl, R 3 and R 4 are each lower alkyl and R 5 is hydroxymethyl, and pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
33 words
A compound according to claim 2, wherein R 2 is [N-lower alkyl-N-mono- or dihalobenzyl]-amino(lower)alkyl, and R 1 , R 3 , R 4 and R 5 are each as defined in claim 2.
Claim 5
Dependent Claim
31 words
A compound according to claim 3, wherein R 1 is 2-cyano or 2-trifluoromethyl, R 2 is 2-(N-methyl-N-4-mono- or 3,4-dichlorobenzylamino)ethyl, R 3 is ethyl, R 4 is methyl and R 5 hydroxymethyl.
Claim 6
Dependent Claim
31 words
A compound according to claim 4, wherein R 1 is 2-cyano, R 2 is 2-(N-methyl-N-4-chlorobenzylamino)ethyl, R 3 is ethyl, R 4 is methyl and R 5 is hydroxymethyl, and its hydrochloride.
Claim 7
Dependent Claim
28 words
A compound according to claim 4, wherein R 1 is 2-trifluoromethyl, R 2 is 2-(N-methyl-N-3,4-dichlorobenzylamino)ethyl, R 3 is ethyl, R 4 is methyl, and R 5 is hydroxymethyl.
Claim 8
Dependent Claim
31 words
A pharmaceutical composition for treatment of hypertension comprising, as an active ingredient, an effective amount of the compound of claim 1, in association with a nontoxic, pharmaceutically acceptable carrier or excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-11 | 1987-01-10 | 1987-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-11 | 1991-01-10 | 1991-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-11 | 1995-01-10 | 1995-07-12 | $7700.00 | Window Closed / Lapsed |