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US4888998A Expired / Lapsed US ⏱️ 0.0 years remaining

Sample handling system

Assignee: Beckman Coulter Inc
•
Filing: 1989-05-17
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Granted: 1989-12-26
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Expires: 2009-05-17
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Abstract

Abstract A sample handling system including a sample injection cell having an open chamber in turn comprising an upper portion for washing a sample handling probe and a lower portion adapted to reeive the probe for injection of a sample and fluid mixture into a flow analysis device. The cell enables the probe to be withdrawn from the cell and moved to other analysis modules for injection of sample therein. The cell includes a seal between the upper portion and lower portion of the chamber and the probe includes a mating seal near the tip of the probe. A plurality of conduits are formed into the cell for flowing sample and a fluid such as diluent through the cell to a flow analysis device and for filling the cell for washing the probe tip.

Inventors

  • 👤 Edmund E. Buzza
  • 👤 Delbert D. Jackson

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 18:18
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/10; G01N35/1095; G01N35/1097; G01N35/1004

Claims Analysis

Total Claims: 21
Claim 1
Independent Claim 212 words
A sample handling system, comprising: a moveable fluid delivery probe having a tip and a sealing surface proximate the tip; a sample carrying location; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber; and at least two conduits in communication with the second portion of the chamber; the system further including displacement means for moving the probe to the sample carrying location, inserting the probe tip into the sample carrying location, removing the probe tip from the sample carrying location, moving the probe to the sample injection cell, inserting the probe tip into the sample injection cell until the probe tip is in the second portion of the chamber and the sealing surface engages and seals against the sealing means, and removing the probe and probe tip from the sample injection cell.
Claim 2
Dependent Claim 212 words
A sample handling system, comprising: a moveable fluid delivery probe having a tip and a sealing surface proximate the tip; a sample carrying location; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber; and at least two conduits in communication with the second portion of the chamber; the system further including displacement means for moving the probe to the sample carrying location, inserting the probe tip into the sample carrying location, removing the probe tip from the sample carrying location, moving the probe to the sample injection cell, inserting the probe tip into the sample injection cell until the probe tip is in the second portion of the chamber and the sealing surface engages and seals against the sealing means, and removing the probe and probe tip from the sample injection cell.
Claim 3
Dependent Claim 42 words
A system as in claim 1 wherein the first portion of the chamber includes wall means tapering from the open end of the chamber toward the sealing means for guiding the probe toward engagement of the sealing surface and the sealing means.
Claim 4
Dependent Claim 63 words
A system as in claim 1 wherein the probe includes a first annular seal proximate the tip thereof, the first annular seal defining the sealing surface, and the sealing means comprises a second annular seal disposed between the first and second portions of the chamber, the inside diameter of the second annular seal being greater than the outside diameter of the probe tip.
Claim 5
Dependent Claim 63 words
A system as in claim 1 wherein the sample injection cell further includes a conduit in communication with the first portion of the chamber and the system further includes pump means for pumping fluid through the chamber via the conduit in communication with the first portion of the chamber and one of the conduits in communication with the second portion of the chamber.
Claim 6
Dependent Claim 23 words
A system as in claim 1 wherein the probe sealing surface has a diameter greater than the outside diameter of the probe tip.
Claim 7
Dependent Claim 198 words
A sample handling system, comprising: a fluid delivery probe having a tip and a sealing surface proximate the tip; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber; the system further including a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 8
Dependent Claim 198 words
A sample handling system, comprising: a fluid delivery probe having a tip and a sealing surface proximate the tip; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber; the system further including a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 9
Dependent Claim 55 words
A system as in claim 6 wherein the system includes control means for inserting the probe tip into the first portion of the chamber, and for inserting the probe tip through the first portion of the chamber and into the second portion of the chamber and for engaging the sealing surface by the sealing means.
Claim 10
Dependent Claim 41 words
A system as in claim 7 wherein the first portion of the chamber includes walls tapering from the open end of the chamber toward the sealing means for guiding the probe toward engagement of the sealing surface and the sealing means.
Claim 11
Dependent Claim 308 words
A sample handling system comprising: a fluid delivery probe having a tip and a sealing surface proximate the tip; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber; a conduit in communication with the first portion of the chamber; at least two conduits in communication with second portion of the chamber; the system further including control means (a) for inserting the probe tip into the first portion of the chamber, and (b) for inserting the probe tip through the first portion of the chamber and into the second portion of the chamber and for engaging the sealing surface by the sealing means; pump means for pumping fluid through the chamber via one of the conduits in fluid communication with the second portion of the chamber and the conduit in communication with the first portion of the chamber; fluid pumping means for pumping fluid through a second one of the at least two conduits when the probe tip is sealed within the second portion of the chamber; and a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 12
Dependent Claim 308 words
A sample handling system comprising: a fluid delivery probe having a tip and a sealing surface proximate the tip; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber; a conduit in communication with the first portion of the chamber; at least two conduits in communication with second portion of the chamber; the system further including control means (a) for inserting the probe tip into the first portion of the chamber, and (b) for inserting the probe tip through the first portion of the chamber and into the second portion of the chamber and for engaging the sealing surface by the sealing means; pump means for pumping fluid through the chamber via one of the conduits in fluid communication with the second portion of the chamber and the conduit in communication with the first portion of the chamber; fluid pumping means for pumping fluid through a second one of the at least two conduits when the probe tip is sealed within the second portion of the chamber; and a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 13
Dependent Claim 201 words
A sample injection cell for use with a fluid delivery probe and means for moving the probe relative to the cell, the fluid delivery probe including a tip and a sealing surface proximate the tip, the cell comprising: a body having a chamber adapted to receive the probe, the chamber including an open end, a closed end, a first portion of the chamber proximate the open end, and a second portion of the chamber proximate the closed end; a resilient annular seal disposed between the first portion of the chamber and the second portion of the chamber and adapted for engaging the sealing surface carried by probe, the inside diameter of the annular seal being greater than the outside diameter of the probe tip, the first portion of the chamber including a generally conical wall and a cylindrical wall, the conical wall having a large diameter end proximate the open end of the chamber, and a small diameter end, and the cylindrical wall of the chamber being intermediate the small diameter end and the annular seal; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber.
Claim 14
Dependent Claim 201 words
A sample injection cell for use with a fluid delivery probe and means for moving the probe relative to the cell, the fluid delivery probe including a tip and a sealing surface proximate the tip, the cell comprising: a body having a chamber adapted to receive the probe, the chamber including an open end, a closed end, a first portion of the chamber proximate the open end, and a second portion of the chamber proximate the closed end; a resilient annular seal disposed between the first portion of the chamber and the second portion of the chamber and adapted for engaging the sealing surface carried by probe, the inside diameter of the annular seal being greater than the outside diameter of the probe tip, the first portion of the chamber including a generally conical wall and a cylindrical wall, the conical wall having a large diameter end proximate the open end of the chamber, and a small diameter end, and the cylindrical wall of the chamber being intermediate the small diameter end and the annular seal; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber.
Claim 15
Dependent Claim 264 words
A sample handling system, comprising: a fluid delivery probe having a tip and a first annular seal proximate the tip; a sample injection cell comprising: a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the first annular seal; a second annular seal disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end and adapted for engaging the first annular seal when the probe tip is within the second portion of the chamber, the inside diameter of the second annular seal being greater than the outside diameter of the probe tip; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber; the system further including control means (a) for inserting the probe tip into the first portion of the chamber, and (b) for inserting the probe tip through the first portion of the chamber and the second annular seal and for pressing the first and second annular seals together to form a seal therebetween; a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe; and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 16
Dependent Claim 264 words
A sample handling system, comprising: a fluid delivery probe having a tip and a first annular seal proximate the tip; a sample injection cell comprising: a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end, a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the first annular seal; a second annular seal disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end and adapted for engaging the first annular seal when the probe tip is within the second portion of the chamber, the inside diameter of the second annular seal being greater than the outside diameter of the probe tip; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber; the system further including control means (a) for inserting the probe tip into the first portion of the chamber, and (b) for inserting the probe tip through the first portion of the chamber and the second annular seal and for pressing the first and second annular seals together to form a seal therebetween; a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe; and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 17
Dependent Claim 37 words
A system as in claim 11 further including fluid pumping means for pumping fluid through a second one of the at least two conduits when the probe tip is sealed within the second portion of the chamber.
Claim 18
Dependent Claim 254 words
A sample handling system, comprising: a moveable fluid delivery probe having a tip and a sealing surface proximate the tip; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end; a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber and at least two conduits in communication with the second portion of the chamber; the system further including displacement means for inserting the probe tip into the sample injection cell until the probe tip is in the second portion of the chamber and the sealing surface engages and seals against the sealing means, and for removing the probe from the sample injection cell. a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe, the displacement means further includes means for moving the probe to deposit fluid from the probe into the sample analyzing means; and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 19
Dependent Claim 254 words
A sample handling system, comprising: a moveable fluid delivery probe having a tip and a sealing surface proximate the tip; a sample injection cell comprising a body having a chamber adapted to receive the probe, the chamber including an open end and a closed end; a first portion of the chamber proximate the open end being sized to freely receive the probe tip and the sealing surface carried by the probe; sealing means disposed between the first portion of the chamber and a second portion of the chamber proximate the closed end for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber and at least two conduits in communication with the second portion of the chamber; the system further including displacement means for inserting the probe tip into the sample injection cell until the probe tip is in the second portion of the chamber and the sealing surface engages and seals against the sealing means, and for removing the probe from the sample injection cell. a plurality of sample analyzing means each adapted to accept and analyze fluid deposited in said sample analyzing means by the probe, the displacement means further includes means for moving the probe to deposit fluid from the probe into the sample analyzing means; and flow analyzing means in fluid communication with one of the conduits in communication with the second portion of the chamber for analyzing fluids injected into the second portion of the chamber from the probe.
Claim 20
Dependent Claim 186 words
A sample injection cell for use with a fluid delivery probe and probe moving means for moving the probe relative to the cell, the fluid delivery probe including a tip and a sealing surface proximate the tip, the cell comprising: a body having a chamber adapted to receive the probe, the chamber including an open end, a closed end, and a second portion of the chamber proximate the closed end; a resilient annular seal retained within the chamber and disposed between the first portion of the chamber and the second portion of the chamber and adapted for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber, the inside diameter of the annular seal being greater than the outside diameter of the probe tip, the first portion of the chamber including a generally conical wall tapering from a diameter defined by the open end of the chamber toward the annular seal; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber.
Claim 21
Dependent Claim 186 words
A sample injection cell for use with a fluid delivery probe and probe moving means for moving the probe relative to the cell, the fluid delivery probe including a tip and a sealing surface proximate the tip, the cell comprising: a body having a chamber adapted to receive the probe, the chamber including an open end, a closed end, and a second portion of the chamber proximate the closed end; a resilient annular seal retained within the chamber and disposed between the first portion of the chamber and the second portion of the chamber and adapted for engaging the sealing surface carried by the probe and sealing the probe tip within the second portion of the chamber, the inside diameter of the annular seal being greater than the outside diameter of the probe tip, the first portion of the chamber including a generally conical wall tapering from a diameter defined by the open end of the chamber toward the annular seal; a conduit in communication with the first portion of the chamber; and at least two conduits in communication with the second portion of the chamber.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-12-25 1993-06-26 1993-12-26 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-12-25 1997-06-26 1997-12-26 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-12-25 2001-06-26 2001-12-26 $7700.00 Window Closed / Lapsed

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