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US4888276A
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Method and composition for the diagnosis of Lyme disease
Assignee: BIOWHITTRAKER Inc A CORP OF
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Filing: 1986-06-26
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Granted: 1989-12-19
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Expires: 2006-06-26
Abstract
Abstract A reliable, rapid, inexpensive and noninvasive method is provided for the diagnosis of Lyme disease by the detection of antigens of the spirochete responsible for that disease, Borrelia burgdorferi, in the urine of an affected individual.
Inventors
- 👤 Charles E. Shelburne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:23
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56911; G01N2800/00; G01N2800/52; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
61 words
A method for detecting the presence of the organism Borrelia burgdorferi comprising the steps of: (a) combining a human urine sample or fraction thereof with antibodies specific for at least one antigen of said organism, wherein any of said antigen present in said urine binds to said antibodies to form an antigen-antibody complex; and (b) detecting the presence of said complex.
Claim 2
Independent Claim
61 words
A method for detecting the presence of the organism Borrelia burgdorferi comprising the steps of: (a) combining a human urine sample or fraction thereof with antibodies specific for at least one antigen of said organism, wherein any of said antigen present in said urine binds to said antibodies to form an antigen-antibody complex; and (b) detecting the presence of said complex.
Claim 3
Dependent Claim
29 words
A method according to claim 1 wherein said antigen is selected from the group consisting of the 31,000 daltons and 34,000 daltons cellular proteins, and lipopolysaccharide of B. burgdorferi.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein said antibody is monoclonal antibody.
Claim 5
Dependent Claim
22 words
A method according to claim 3 wherein said monoclonal antibody is produced by a hybridoma cell line having ATCC Accession No. HB9126.
Claim 6
Dependent Claim
24 words
A method according to claim 1 wherein said method includes electrophoresis of said urine followed by immunologically probing a transblot of the resultant gel.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein said method is an enzyme linked immunosorbent assay.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-18 | 1993-06-19 | 1993-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-18 | 1997-06-19 | 1997-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-18 | 2001-06-19 | 2001-12-19 | $7700.00 | Window Closed / Lapsed |