US4880585A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Continuous method of tableting
Assignee: BASF SE
•
Filing: 1988-12-22
•
Granted: 1989-11-14
•
Expires: 2008-12-22
Abstract
Abstract Extrudable pharmaceutical mixtures are tableted by a continuous method in which the mixture is extruded and the still deformable extrudate is pressed between two rollers which are driven in opposite directions and possess depressions opposite one another in the roller shell, the form of these depressions determining the tablet shape.
Inventors
- 👤 Roger G. Klimesch
- 👤 Gerhard Bleckmann
- 👤 Karl-Peter Farwerck
- 👤 Hans-Helmut Goertz
- 👤 Lothar Schlemmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:49
CPC Classifications
A; A61; A61J; A61J3/00; A61J3/06; A61J3/10; A61K; A61K9/00; A61K9/20; A61K9/2095; B; B29; B29B; B29B9/00; B29B9/02; B29B9/06; B30; B30B; B30B11/00; B30B11/16; B30B15/00; B30B15/30; B30B15/302; B30B15/308; A61J2200/00; A61J2200/20; B29K; B29K2503/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
100 words
A continuous method for producing separate tablets of an extrudable pharmaceutical mixture which comprises: mixing a pharmaceutically active compound and an N-vinylpyrrolid-2-one (NVP) polymer containing 30 to 100% by weight NVP in an extruder to form a melt, said polymer having a K value of from 10 to 100, said mixture having a glass transition point of less than 180° C.; extruding the melt and pressing the still deformable extrudate between the surfaces of two rollers driven in opposite directions, the surfaces of said rollers having opposed depressions, whereby, separate tablets having the shape of the opposed depressions are formed.
Claim 2
Dependent Claim
100 words
A continuous method for producing separate tablets of an extrudable pharmaceutical mixture which comprises: mixing a pharmaceutically active compound and an N-vinylpyrrolid-2-one (NVP) polymer containing 30 to 100% by weight NVP in an extruder to form a melt, said polymer having a K value of from 10 to 100, said mixture having a glass transition point of less than 180° C.; extruding the melt and pressing the still deformable extrudate between the surfaces of two rollers driven in opposite directions, the surfaces of said rollers having opposed depressions, whereby, separate tablets having the shape of the opposed depressions are formed.
Claim 3
Dependent Claim
36 words
The method of claim 1, wherein an active compound-containing melt of an N-vinylpyrrolid-2-one (NVP) polymer is extruded and pressed, the NVP polymer being prepared either in an organic solvent or using an organic peroxide in water.
Claim 4
Dependent Claim
42 words
The method of claim 1, wherein the K value of the polymer is from 12 to 35 and the mixture has a softening or melting point of from 60° to 130° C. and a glass transition point of less then 130° C.
References Cited (Backward Citations)
US99083A
Cited
FR537444A
Cited
US2988774A
Cited
DE1766546A1
Cited
US3755527A
Cited
US3758679A
Cited
US3859407A
Cited
US3936522A
Cited
US3843299A
Cited
US4028024A
Cited
US4191723A
Cited
US4130521A
Cited
US4256448A
Cited
US4411611A
Cited
US4340557A
Cited
US4451260A
Cited
US4520179A
Cited
US4520180A
Cited
US4569837A
Cited
US4801460A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-13 | 1993-05-15 | 1993-11-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-13 | 1997-05-15 | 1997-11-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-13 | 2001-05-15 | 2001-11-14 | $7700.00 | Window Closed / Lapsed |