US4879109A
Expired / Lapsed
US
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Method for treating burns
Assignee: Emory University
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Filing: 1988-12-29
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Granted: 1989-11-07
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Expires: 2008-12-29
Abstract
Abstract In accordance with the present invention, a method and composition is provided for treating pathological hydrophobic interactions in biological fluids in which there is acute impairment of the circulation, especially the microcirculation. More particularly, the present invention relates to compositions and methods for treating circulatory diseases comprising using certain ethylene oxide-propylene oxide condensation surface active copolymers either alone or in combination other compounds. Also contemplated in the present invention is a method for preserving a suspension of platelets. The method comprises adding an effective amount of a surface active copolymer. The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula; HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 95% by weight of the compound.
Inventors
- 👤 Robert L. Hunter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:12
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61K31/77; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49; A61P; A61P7/00; A61P7/02; Y; Y10; Y10S; Y10S424/00; Y10S424/13
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
106 words
A method of reducing tissue damage due to burns in an animal or human comprising the step of injecting into the animal or human with the burn an effective of amount of a solution of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 40000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 2
Independent Claim
106 words
A method of reducing tissue damage due to burns in an animal or human comprising the step of injecting into the animal or human with the burn an effective of amount of a solution of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 40000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 3
Dependent Claim
76 words
The method of claim 1 wherein said surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3250, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 4
Dependent Claim
50 words
The method of claim 1 wherein said surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 5
Independent Claim
107 words
A method of reducing tissue damage due to burns in an animal or human comprising the step of intravenously injecting into the animal or human with the burn an effective of amount of a solution of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 6
Independent Claim
107 words
A method of reducing tissue damage due to burns in an animal or human comprising the step of intravenously injecting into the animal or human with the burn an effective of amount of a solution of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 7
Dependent Claim
76 words
The method of claim 4 wherein said surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3250, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 8
Dependent Claim
50 words
The method of claim 4 wherein said surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 9
Independent Claim
107 words
A method of reducing tissue damage due to burns in an animal or human comprising the step of intramuscularly injecting into the animal or human with the burn an effective of amount of a solution of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 10
Independent Claim
107 words
A method of reducing tissue damage due to burns in an animal or human comprising the step of intramuscularly injecting into the animal or human with the burn an effective of amount of a solution of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 11
Dependent Claim
76 words
The method of claim 7 wherein said surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3250, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 95% by weight of the compound.
Claim 12
Dependent Claim
50 words
The method of claim 7 wherein said surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
References Cited (Backward Citations)
US3740421A
Cited
US3450502A
Cited
US3641240A
Cited
US3577522A
Cited
US3590125A
Cited
US3980772A
Cited
US3956259A
Cited
US4073886A
Cited
US4186253A
Cited
US4609546A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-11-06 | 1993-05-08 | 1993-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-06 | 1997-05-08 | 1997-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-06 | 2001-05-08 | 2001-11-07 | $7700.00 | Window Closed / Lapsed |