Chromatographic process

Claim 1

An improved process for separating ionizable chemical substances from a solution mixture by ion exchange chromatography of the type using a stationary phase consisting of a chemically modified support material capable of reversibly fixing macromolecules wherein the improvement comprises: providing a hydroxy bearing support material, reacting the support material with an organotitanate of the formula, R.sub.n --Ti--R'.sub.4-n wherein n is 1,2, or 3, wherein R n is a hydrolyzable group linked to titanium through oxygen and is selected from the group consisting of alkoxy, ##STR43## wherein R' is a hydrophobic organofunctional group linked to titanium through oxygen and is each independently selected from alkoxy, arylalkoxy, alkyl ester, acrylate, methacrylate, alkenylester, alkyl phosphato, alkyl pyrophosphato, aminoalkoxy, aminoalkylarylester and quaternary ammonium salt, contacting the organotitanate reacted support material with a solution mixture of chemical substances one constituent of which has an ionizable functionality so as to reversibly fix the chemical substance with ionizable functionality to the organotitanate reacted support material, eluting the fixed ionizable chemical substance with an ionic solution.