US4871865A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tricyclic aromatic compounds
Assignee: SmithKline Beecham Corp
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Filing: 1986-08-07
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Granted: 1989-10-03
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Expires: 2006-08-07
Abstract
Abstract The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R 1 is --CH 2 --CH 2 --, CH 2 --O-- or --O--CH 2 --; R 2 and R 3 are the same or different and are each hydrogen, C 1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R 4 is a single bond or a C 1-7 bivalent aliphatic hydrocarbon group and may be joined to the aromatic ring system at the 2,3,8 or 9 positions; n is 0 to 3, and their use as anithistamine and antiasthma agents.
Inventors
- 👤 O. William Lever, Jr.
- 👤 Harry J. Leighton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:54
CPC Classifications
C; C07; C07D; C07D313/00; C07D313/02; C07D313/06; C07D313/10; C07D313/12; A; A61; A61P; A61P11/00; A61P37/00; A61P37/08; A61P43/00; C07C; C07C229/00; C07C229/38; C07D313/14; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/30; C07C2603/32
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
64 words
A compound of formula (I) ##STR10## or a pharmacologically and pharmaceutically acceptable salt thereof; wherein R 1 is --CH 2 --O--, R 2 and R 3 are the same or different and are each hydrogen or C 1-4 alkyl, R 4 is a C 1-2 bivalent hydrocarbon group and is joined to the aromatic ring system at the 2 position and n is 2.
Claim 2
Dependent Claim
64 words
A compound of formula (I) ##STR10## or a pharmacologically and pharmaceutically acceptable salt thereof; wherein R 1 is --CH 2 --O--, R 2 and R 3 are the same or different and are each hydrogen or C 1-4 alkyl, R 4 is a C 1-2 bivalent hydrocarbon group and is joined to the aromatic ring system at the 2 position and n is 2.
Claim 3
Dependent Claim
14 words
The compound of claim 1 in which R 2 and R 3 are methyl.
Claim 4
Dependent Claim
9 words
The compound of claim 1 which is (z-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acrylic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |