Patent US4138597A successfully refreshed from Google Patents.
US4307245A
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Amitriptyline conjugates to antigenic proteins and enzymes
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1980-04-07
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Granted: 1981-12-22
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Expires: 2000-04-07
Abstract
Abstract Amitriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of amitriptyline, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of amitriptyline.
Inventors
- 👤 Mae W. Hu
- 👤 Prithipal Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 18:42
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; C; C07; C07K; C07K16/00; C07K16/44; Y; Y10; Y10S; Y10S436/00; Y10S436/823
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
57 words
Compound of the formula; Ami--X--RCO--Z wherein: Ami is of the formula: ##STR3## X is methylene or carbonyl; Z is hydrogen, hydroxyl, alkoxy of from 1 to 6 carbon atoms, N-oxy succinimide or p-nitrophenoxy ester; and R is an aliphatic hydrocarbon linking group of from one to seven carbon atoms having from zero to one site of unsaturation.
Claim 2
Dependent Claim
57 words
Compound of the formula; Ami--X--RCO--Z wherein: Ami is of the formula: ##STR3## X is methylene or carbonyl; Z is hydrogen, hydroxyl, alkoxy of from 1 to 6 carbon atoms, N-oxy succinimide or p-nitrophenoxy ester; and R is an aliphatic hydrocarbon linking group of from one to seven carbon atoms having from zero to one site of unsaturation.
Claim 3
Dependent Claim
45 words
Compound according to claim 1 and of the formula: (Ami--CH.sub.2 --R.sup.1 CO--) Z.sup.1 wherein: Ami is defined in claim 1; R 1 is alkylene of from 1 to 7 carbon atoms; Z 1 is hydrogen, hydroxyl, or alkoxy of from 1 to 6 carbon atoms.
Claim 4
Dependent Claim
10 words
Compound according to claim 2, wherein Z 1 is hydroxyl.
Claim 5
Dependent Claim
17 words
Compound according to claim 2, wherein Z 1 is alkoxyl of from 1 to 3 carbon atoms.
Claim 6
Dependent Claim
1 words
3-(γ-carboxypropyl)amitriptyline.
Claim 7
Dependent Claim
1 words
3-(γ-carboxypropyl)amitriptyline.
Claim 8
Dependent Claim
1 words
2-(γ-carboxypropyl)amitriptyline.
Claim 9
Dependent Claim
1 words
2-(γ-carboxypropyl)amitriptyline.
References Cited (Backward Citations)
US3309404A
Cited
US3324170A
Cited
US3379750A
Cited
US3234279A
Cited
US3372196A
Cited
US3981917A
Cited
US3445519A
Cited
US3818020A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-21 | 1985-06-22 | 1985-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-21 | 1989-06-22 | 1989-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-21 | 1993-06-22 | 1993-12-22 | $7700.00 | Window Closed / Lapsed |