Patent US4865870A successfully refreshed from Google Patents.
US4865870A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for rendering a substrate surface antithrombogenic
Assignee: Becton Dickinson and Co
•
Filing: 1988-07-07
•
Granted: 1989-09-12
•
Expires: 2008-07-07
Abstract
Abstract A method for heparinizing a substrate includes applying a coating of ammonium salt to a substrate by steeping the substrate in a solution of the salt at an alkaline pH and contacting the coated substrate with a solution of a salt of heparin.
Inventors
- 👤 Can B. Hu
- 👤 Donald D. Solomon
- 👤 Nancy L. Shields
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:22
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
112 words
A method for heparinizing a polymeric substrate comprising: (a) adjusting the pH of a solution of a surface active agent of the ammonium salt type in a solvent to above 7.5, said surface active agent having at least one alkyl group of 8 to 20 carbon atoms; (b) steeping a polymeric substrate in said solution of adjusted pH whereby a coating of said surface active agent forms on said substrate; (c removing said substrate having said coating from said solution of adjusted pH; and (d) immersing said substrate having said coating in a solution of heparin whereby said heparin reacts with said coating of surface active agent to give a heparinized substrate.
Claim 2
Independent Claim
112 words
A method for heparinizing a polymeric substrate comprising: (a) adjusting the pH of a solution of a surface active agent of the ammonium salt type in a solvent to above 7.5, said surface active agent having at least one alkyl group of 8 to 20 carbon atoms; (b) steeping a polymeric substrate in said solution of adjusted pH whereby a coating of said surface active agent forms on said substrate; (c removing said substrate having said coating from said solution of adjusted pH; and (d) immersing said substrate having said coating in a solution of heparin whereby said heparin reacts with said coating of surface active agent to give a heparinized substrate.
Claim 3
Dependent Claim
37 words
The method of claim 1 wherein said polymeric substrate is selected from the group consisting of polyolefin, polyvinyl, polyacrylic, polyester, polyamide, polycarbonate, fluorinated polymer, cellulose acetate, silicone rubber and natural rubber, polyurethane, polyurethaneurea and silicone urethane copolymer.
Claim 4
Dependent Claim
31 words
The method of claim 1 wherein surface active agent is selected from the group consisting of a salt of a primary amine, secondary amine, tertiary amine, alkylenediame and a quaternary salt.
Claim 5
Dependent Claim
28 words
The method of claim 3 wherein said surface active agent is a secondary amine salt having at least one alkyl group of about 1 to 4 carbon atoms.
Claim 6
Dependent Claim
11 words
The method of claim 4 wherein said salt is dodecylmethylamine hydrochloride.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein said pH after adjusting is between from about 8 and 14.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein said adjusting is performed by adding an alkalinizing agent.
Claim 9
Dependent Claim
28 words
The method of claim 6 wherein said alkalinizing agent is selected from the group consisting of an amine soluble in said solvent, a metal hydroxide and ammonium hydroxide.
Claim 10
Dependent Claim
14 words
The method of claim 7 wherein said alkalinizing agent is an alkali metal hydroxide.
Claim 11
Dependent Claim
18 words
The method of claim 1 further comprising treating said heparinized substrate with a dialdehyde to stabilize said heparin.
Claim 12
Dependent Claim
10 words
The method of claim 10 wherein said dialdehyde is glutaraldehyde.
Claim 13
Dependent Claim
25 words
The method of claim 1 further comprising treating said polymeric substrate with a plasma prior to immersing said substrate in said solution of ammonium salt.
Claim 14
Dependent Claim
20 words
The method of claim 12 wherein said polymeric substrate is selected from the group consisting of polypropylene and polytetrafluoro ethylene
Claim 15
Independent Claim
101 words
A method for rendering a substrate antithrombogenic comprising: (a) adjusting the pH of a dispersion of a surface active agent of the ammonium salt type in a solvent to above 7.5; (b) steeping a substrate in said solution of adjusted pH thereby causing a coating of said surface active agent to form on said substrate; (c) removing said substrate having said coating thereon from said solution of adjusted pH; and (d) immersing said substrate having said coating thereon in a solution of a sulfonated polysaccharide whereby said polysaccharide reacts with said coating of surface active agent to give an antithrombogenic substrate.
Claim 16
Independent Claim
101 words
A method for rendering a substrate antithrombogenic comprising: (a) adjusting the pH of a dispersion of a surface active agent of the ammonium salt type in a solvent to above 7.5; (b) steeping a substrate in said solution of adjusted pH thereby causing a coating of said surface active agent to form on said substrate; (c) removing said substrate having said coating thereon from said solution of adjusted pH; and (d) immersing said substrate having said coating thereon in a solution of a sulfonated polysaccharide whereby said polysaccharide reacts with said coating of surface active agent to give an antithrombogenic substrate.
Claim 17
Dependent Claim
24 words
The method cf claim 14 wherein said substrate may be of a material selected from the group consisting of metal, glass, ceramic and polymer.
Claim 18
Independent Claim
99 words
A method for heparinizing a polymeric substrate comprising: (a) adjusting the pH of a solution of dodecylmethylammonium chloride in aqueous medium by adding a sufficient quantity of an alkalinizing agent to raise the pH of said solution to about 10.2; (b) steeping a polymeric substrate in said solution of pH about 10.2 whereby a coating of dodecylmethylamine forms on said substrate; (c) removing said substrate having said coating from said solution of pH about 10.2; and (d) immersing said substrate having said coating in a solution of heparin, said heparin reacting with said coating to give a heparinized substrate.
Claim 19
Independent Claim
99 words
A method for heparinizing a polymeric substrate comprising: (a) adjusting the pH of a solution of dodecylmethylammonium chloride in aqueous medium by adding a sufficient quantity of an alkalinizing agent to raise the pH of said solution to about 10.2; (b) steeping a polymeric substrate in said solution of pH about 10.2 whereby a coating of dodecylmethylamine forms on said substrate; (c) removing said substrate having said coating from said solution of pH about 10.2; and (d) immersing said substrate having said coating in a solution of heparin, said heparin reacting with said coating to give a heparinized substrate.
Claim 20
Dependent Claim
27 words
The method of claim 16 wherein said alkalinizing agent is selected from the group consisting of a water soluble amine, ammonium hydroxide and an alkali metal hydroxide.
Claim 21
Dependent Claim
10 words
The method of claim 16 wherein said substrate is polyurethane.
Claim 22
Dependent Claim
17 words
The method of claim 16 further comprising treating said heparinized surface with glutaraldehyde to stabilize said heparin.
Claim 23
Dependent Claim
18 words
The method of claim 16 wherein said substrate is selected from the group consisting of polypropylene and polytetrafluoroethylene.
Claim 24
Dependent Claim
26 words
The method of claim 20 further comprising treating said substrate with a plasma prior to immersing said substrate in said solution of dodecyl methyl ammonium chloride.
References Cited (Backward Citations)
US3634123A
Cited
US3617344A
Cited
US3810781A
Cited
US4118485A
Cited
US4349467A
Cited
US4613517A
Cited
US4521564A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |