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US3617344A
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Nonthrombogenic plastic surfaces and preparation thereof
Assignee: United States Department of Health and Human Services
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Filing: 1966-08-05
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Granted: 1971-11-02
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Expires: 1986-08-05
Abstract
Abstract A plastic polymer surface rendered substantially nonthrombogenic by heparin chemically combined with quaternary ammonium groups which are chemically bonded to the plastic polymer surface, which is preferably flexible or elastomeric; also several methods of producing same.
Inventors
- 👤 Robert I Leininger
- 👤 Richard D Falb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:18
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0023; Y; Y10; Y10S; Y10S623/00; Y10S623/924; Y10S623/926; Y10T; Y10T428/00; Y10T428/31504; Y10T428/3154; Y10T428/31544; Y10T428/31652; Y10T428/31663; Y10T428/31855; Y10T428/31938
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
18 words
A plastic polymer surface as defined in claim 1, wherein the plastic polymer is a synthetic plastic material.
Claim 2
Dependent Claim
17 words
A plastic polymer surface as defined in claim 1, wherein the plastic polymer is a flexible polymer.
Claim 3
Dependent Claim
17 words
A plastic polymer surface as defined in claim 1, wherein the plastic polymer is an elastomeric polymer.
Claim 4
Dependent Claim
38 words
The process of rendering substantially nonthrombogenic a surface of a plastic polymer article, which comprises the steps of (a) providing said surface with quaternary ammonium groups chemically bonded to the polymer, and (b) heparinizing the quaternary ammonium groups.
Claim 5
Dependent Claim
48 words
A process as defined in claim 5 wherein step (b) is effected by immersing the plastic surface having quaternary ammonium groups chemically bonded thereto in alcoholic sodium heparinate followed by removal from the surface of loosely bound heparin which has not complexed with the chemically bonded ammonium groups.
Claim 6
Dependent Claim
30 words
A process as defined in claim 5 wherein in step (a) the polymer surface is provided with the quaternary ammonium groups by chemical treatment after formation of the polymer surface.
Claim 7
Dependent Claim
32 words
A process as defined in claim 7 wherein in step (a) the polymer surface is provided with the quaternary ammonium groups by (i) chloromethylation followed by (ii) amination with a tertiary amine.
Claim 8
Dependent Claim
23 words
A process as defined in claim 8 wherein the tertiary amine is from the group consisting of triethyl amine, dimethyl aNiline, and pyridine.
Claim 9
Dependent Claim
38 words
A process as defined in claim 7 wherein in step (a) the polymer surface is provided with the quaternary ammonium groups by (i) providing the polymer surface with chloride groups followed by (i) amination with a tertiary amine.
Claim 10
Dependent Claim
47 words
A process as defined in claim 7 wherein in step (a) the polymer surface is provided with the quaternary ammonium groups by (i) providing the surface of the polymer with tertiary amine groups and (ii) quaternizing said tertiary amine groups with the aid of a quaternizing reagent.
Claim 11
Dependent Claim
23 words
A process as defined in claim 1, wherein the quaternizing reagent is selected from the group consisting of methyl iodide and benzyl chloride.
Claim 12
Dependent Claim
35 words
A process as defined in claim 11 wherein in step (a) (i) the polymer surface is provided with the tertiary amine groups by radiation grafting of a tertiary amine to the surface of the polymer.
Claim 13
Dependent Claim
43 words
A process as defined in claim 11, wherein the polymer being heparinized is a polymer having carboxyl groups chemically bonded to its surface, and wherein in step (a) (i) the carboxyl groups are converted to the tertiary amine groups by the Curtius reaction.
Claim 14
Dependent Claim
48 words
A process as defined in claim 11 wherein the polymer being heparinized is a polymer having ester groups chemically bonded to its surface, and wherein in step (a) (i) the ester groups are hydrolyzed to carboxyl groups which are converted to tertiary amine groups by the Curtius reaction.
Claim 15
Dependent Claim
33 words
A process as defined in claim 11, wherein the polymer is selected from the group consisting of polystyrene, polyethylene, tetrafluoroethylene polymer, natural rubber, synthetic elastomer, acrylic polymers, polyesters, polyester-polyurethanes, and maleic anhydride/methylvinylether copolymers.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-11-01 | 1975-05-03 | 1975-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-11-01 | 1979-05-03 | 1979-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-11-01 | 1983-05-03 | 1983-11-02 | $7700.00 | Window Closed / Lapsed |