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US4865598A Expired / Lapsed US ⏱️ 0.0 years remaining

Dispensing system for administering beneficial agent

Assignee: Alza Corp
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Filing: 1988-02-02
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Granted: 1989-09-12
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Expires: 2008-02-02
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Abstract

Abstract A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition in the space, (3) an aqueous sensitive beneficial agent formulation in the space, and (4) at least one passageway in the housing for delivering the beneficial agent from the dispensing device.

Inventors

  • 👤 James B. Eckenhoff

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-28 20:08
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004

Claims Analysis

Total Claims: 13
Claim 1
Independent Claim 198 words
A dispersing device for delivering a beneficial agent formulation to an aqueous fluid environment of use, which dispensing device comprises: (a) wall means for surrounding and forming an internal compartment, said wall means comprising in at least a part a semipermeable composition permeable to the passage of aqueous fluid present in the environment of use; (b) a beneficial agent formulation in the compartment, said beneficial agent formulation forming with aqueous fluid that passes through the semipermeable wall into the compartment a dispensable beneficial agent aqueous formulation; (c) hydrogel means in the compartment for absorbing aqueous fluid for occupying an increasing amount of space in the compartment; (d) density means in the compartment for increasing the weight of the dispersing device, said means having a density greater than the density of aqueous fluid present in the environment of use, and which density means is a powder, granule or pellet mixed with the hydrogel means for absorbing aqueous fluid and retained therein during the dispensing of the dispensable beneficial agent aqueous formulation; and, (e) means in the wall connecting the exterior of the dispensing device with the compartment for delivering the beneficial agent aqueous formulation to the environment of use.
Claim 2
Dependent Claim 198 words
A dispersing device for delivering a beneficial agent formulation to an aqueous fluid environment of use, which dispensing device comprises: (a) wall means for surrounding and forming an internal compartment, said wall means comprising in at least a part a semipermeable composition permeable to the passage of aqueous fluid present in the environment of use; (b) a beneficial agent formulation in the compartment, said beneficial agent formulation forming with aqueous fluid that passes through the semipermeable wall into the compartment a dispensable beneficial agent aqueous formulation; (c) hydrogel means in the compartment for absorbing aqueous fluid for occupying an increasing amount of space in the compartment; (d) density means in the compartment for increasing the weight of the dispersing device, said means having a density greater than the density of aqueous fluid present in the environment of use, and which density means is a powder, granule or pellet mixed with the hydrogel means for absorbing aqueous fluid and retained therein during the dispensing of the dispensable beneficial agent aqueous formulation; and, (e) means in the wall connecting the exterior of the dispensing device with the compartment for delivering the beneficial agent aqueous formulation to the environment of use.
Claim 3
Dependent Claim 29 words
The dispensing for delivering the beneficial agent aqueous formulation to an environment of use according to claim 1, wherein the beneficial agent aqueous formulation comprises an osmotically effective solute.
Claim 4
Dependent Claim 28 words
The dispensing device for delivering the beneficial agent formulation to an environment of use according to claim 1, wherein the beneficial agent formulation comprises an aqueous absorbing polymer.
Claim 5
Dependent Claim 47 words
The dispensing device for delivering the beneficial agent formulation to an environment of use according to claim 1, wherein the means in the wall connecting the exterior of the device with the interior of the device comprises at least one passageway formed in the environment of use.
Claim 6
Dependent Claim 55 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the beneficial agent formulation comprises a member selected from the group consisting of mebendazole, levamisole, albendazole, cambendazole, fenbendazole, parbendazole, oxfendazole, oxybendazole, thiabendazole, tichlorfan, praziquantel, morantel, pyrantel, avermectin, ivermectin, oxantel, piperazine, diethylcarbamazine, tetramisole, polaxalene, selenium, and zearalanol.
Claim 7
Dependent Claim 30 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the beneficial agent aqueous formulation is lipidfree in the dispensing device.
Claim 8
Dependent Claim 36 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the formulation consists essentially of materials that mixed with an aqueous fluid to form an aqueous formulation.
Claim 9
Dependent Claim 28 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the formulation is essentially free of thermo absorbing components.
Claim 10
Dependent Claim 169 words
The dispensing device for delivering a beneficial agent aqueous formulation to an aqueous environment of use, wherein the dispensing device comprises: (a) wall means for surrounding and forming an internal compartment, said wall means comprising in at least a part a composition permeable to the passage of an aqueous fluid present in the environment of use; (b) hydrogel means in the compartment for absorbing the aqueous fluid for occupying a larger area of the compartment; (c) a beneficial agent formulation in the compartment, which beneficial agent formulation imbibes aqueous fluid through the wall for forming with an aqueous fluid a dispensable beneficial agent aqueous formulation; (d) density means in the compartment for increasing the weight of the dispensing device said density means having a density of at least one and mixed as a powder, granule or pallet with the beneficial agent formulation; and (e) means in the wall connecting the exterior of the d®vice with the compartment for delivering the beneficial agent aqueous formulation to the environment of use.
Claim 11
Dependent Claim 169 words
The dispensing device for delivering a beneficial agent aqueous formulation to an aqueous environment of use, wherein the dispensing device comprises: (a) wall means for surrounding and forming an internal compartment, said wall means comprising in at least a part a composition permeable to the passage of an aqueous fluid present in the environment of use; (b) hydrogel means in the compartment for absorbing the aqueous fluid for occupying a larger area of the compartment; (c) a beneficial agent formulation in the compartment, which beneficial agent formulation imbibes aqueous fluid through the wall for forming with an aqueous fluid a dispensable beneficial agent aqueous formulation; (d) density means in the compartment for increasing the weight of the dispensing device said density means having a density of at least one and mixed as a powder, granule or pallet with the beneficial agent formulation; and (e) means in the wall connecting the exterior of the d®vice with the compartment for delivering the beneficial agent aqueous formulation to the environment of use.
Claim 12
Dependent Claim 47 words
The dispensing device for delivering the beneficial agent formulation to an environment of use according to claim 9, wherein the means in the wall connecting the exterior of the device with the interior of the device comprises at least one passageway formed in the environment of use.
Claim 13
Dependent Claim 56 words
The dispensing device for delivering the beneficial agent aqueous formulation to the environment of use according to claim 9, wherein the beneficial agent formulation comprises a member selected from the group consisting of mebendazole, levamisole, albendazole, cambendazole, fenbendazole, parbendazole, oxfendazole, oxybendazole, thiabendazole, tichlorfan, praziquantel, morantel, pyrantel, avermectin, ivermectin, oxantel, piperazine, diethylcarbamazine, tetramisole polaxalene, selenium, and zearalanol.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-09-11 1993-03-13 1993-09-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-09-11 1997-03-13 1997-09-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-09-11 2001-03-13 2001-09-12 $7700.00 Window Closed / Lapsed

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