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US4857187A Expired / Lapsed US ⏱️ 0.0 years remaining

Multistage mixer-settler centrifuge

Assignee: United States Department of Health and Human Services
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Filing: 1987-09-28
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Granted: 1989-08-15
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Expires: 2007-09-28
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Abstract

Abstract A method and apparatus for chromatography employ a vibration driven mixing device mounted inside a column. One end of the mixing device is held in place by a stopper while the other end is free to vibrate back and forth. The mixture at the free end is efficiently mixed while the mixture at the held end remains undisturbed. The undisturbed portion can then be removed. This invention is particularly applicable to centrifugal chromatography where the vibration is produced by high frequency oscillation in the centrifugal force field.

Inventors

  • 👤 Yoichiro Ito

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-09 17:58
CPC Classifications
B; B01; B01D; B01D15/00; B01D15/08; G; G01; G01N; G01N30/00; G01N30/02; G01N30/26; G01N30/38; G01N30/42; G01N2030/381; G01N30/04; G01N30/16; G01N30/60; G01N30/6052

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 241 words
A planetary centrifuge comprising a separation column comprising a plurality of essentially cylindrical receptacles connected in series between a supply means and a collection means by a plurality of flow tubes; at least one of said flow tube being for transferring a mobile phase from said supply means to the first receptacle in said series; at least another one of said flow tubes being for transferring a mobile phase from the last receptacle of said series to said collection means; the remainder of said flow tubes being for transferring a mobile phase from one receptacle in said series to the succeeding receptacle in said series; mixing means with each said receptacle comprising an elastic elongated rod having a free end within said receptacle and a fixed end, outside said receptacle, said rod extending axially within said receptacle for at least a majority of the depth of said receptacle, said free end of said rod being adapted to oscillate when its respective receptacle is subjected to an oscillating force field; the flow tubes and rods extending through one end of said receptacles; and the separation column being mounted about a column holder so that the cylindrical axes of said receptacles are radially oriented with respect to a central axis said column holder about which said column holder is rotatable, said column holder being fixed within a frame so as to be revolvable about a planetary axis spaced way form said central axis.
Claim 2
Dependent Claim 241 words
A planetary centrifuge comprising a separation column comprising a plurality of essentially cylindrical receptacles connected in series between a supply means and a collection means by a plurality of flow tubes; at least one of said flow tube being for transferring a mobile phase from said supply means to the first receptacle in said series; at least another one of said flow tubes being for transferring a mobile phase from the last receptacle of said series to said collection means; the remainder of said flow tubes being for transferring a mobile phase from one receptacle in said series to the succeeding receptacle in said series; mixing means with each said receptacle comprising an elastic elongated rod having a free end within said receptacle and a fixed end, outside said receptacle, said rod extending axially within said receptacle for at least a majority of the depth of said receptacle, said free end of said rod being adapted to oscillate when its respective receptacle is subjected to an oscillating force field; the flow tubes and rods extending through one end of said receptacles; and the separation column being mounted about a column holder so that the cylindrical axes of said receptacles are radially oriented with respect to a central axis said column holder about which said column holder is rotatable, said column holder being fixed within a frame so as to be revolvable about a planetary axis spaced way form said central axis.
Claim 3
Dependent Claim 14 words
The planetary centrifuge of claim 1, wherein said mixing means comprises a solid rod.
Claim 4
Dependent Claim 16 words
The planetary centrifuge of claim 1, wherein said mixing means comprises one of said flow tubes.
Claim 5
Dependent Claim 29 words
The planetary centrifuge of claim 1, wherein said free end of said rod extends axially almost to one end of said receptacle most distal said fixed end of receptacle.
Claim 6
Dependent Claim 24 words
The planetary centrifuge of claim 1, wherein said plurality of receptacles are arranged in a plurality of longitudinally extending rows upon said column holder.
Claim 7
Dependent Claim 18 words
The planetary centrifuge of claim 5, wherein a weight is attached to the free end of said rod.
Claim 8
Dependent Claim 36 words
The planetary centrifuge of claim 1, wherein at least one end of said receptacle is sealed by a stopper, said flow tubes and rod connected to said receptacles extending through and being fixed within said stopper.

References Cited (Backward Citations)

US3856669A Cited
US3830369A Cited
US4046515A Cited
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US4058460A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-08-14 1993-02-13 1993-08-15 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-08-14 1997-02-13 1997-08-15 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-08-14 2001-02-13 2001-08-15 $7700.00 Window Closed / Lapsed

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