US4857187A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Multistage mixer-settler centrifuge
Assignee: United States Department of Health and Human Services
•
Filing: 1987-09-28
•
Granted: 1989-08-15
•
Expires: 2007-09-28
Abstract
Abstract A method and apparatus for chromatography employ a vibration driven mixing device mounted inside a column. One end of the mixing device is held in place by a stopper while the other end is free to vibrate back and forth. The mixture at the free end is efficiently mixed while the mixture at the held end remains undisturbed. The undisturbed portion can then be removed. This invention is particularly applicable to centrifugal chromatography where the vibration is produced by high frequency oscillation in the centrifugal force field.
Inventors
- 👤 Yoichiro Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:58
CPC Classifications
B; B01; B01D; B01D15/00; B01D15/08; G; G01; G01N; G01N30/00; G01N30/02; G01N30/26; G01N30/38; G01N30/42; G01N2030/381; G01N30/04; G01N30/16; G01N30/60; G01N30/6052
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
241 words
A planetary centrifuge comprising a separation column comprising a plurality of essentially cylindrical receptacles connected in series between a supply means and a collection means by a plurality of flow tubes; at least one of said flow tube being for transferring a mobile phase from said supply means to the first receptacle in said series; at least another one of said flow tubes being for transferring a mobile phase from the last receptacle of said series to said collection means; the remainder of said flow tubes being for transferring a mobile phase from one receptacle in said series to the succeeding receptacle in said series; mixing means with each said receptacle comprising an elastic elongated rod having a free end within said receptacle and a fixed end, outside said receptacle, said rod extending axially within said receptacle for at least a majority of the depth of said receptacle, said free end of said rod being adapted to oscillate when its respective receptacle is subjected to an oscillating force field; the flow tubes and rods extending through one end of said receptacles; and the separation column being mounted about a column holder so that the cylindrical axes of said receptacles are radially oriented with respect to a central axis said column holder about which said column holder is rotatable, said column holder being fixed within a frame so as to be revolvable about a planetary axis spaced way form said central axis.
Claim 2
Dependent Claim
241 words
A planetary centrifuge comprising a separation column comprising a plurality of essentially cylindrical receptacles connected in series between a supply means and a collection means by a plurality of flow tubes; at least one of said flow tube being for transferring a mobile phase from said supply means to the first receptacle in said series; at least another one of said flow tubes being for transferring a mobile phase from the last receptacle of said series to said collection means; the remainder of said flow tubes being for transferring a mobile phase from one receptacle in said series to the succeeding receptacle in said series; mixing means with each said receptacle comprising an elastic elongated rod having a free end within said receptacle and a fixed end, outside said receptacle, said rod extending axially within said receptacle for at least a majority of the depth of said receptacle, said free end of said rod being adapted to oscillate when its respective receptacle is subjected to an oscillating force field; the flow tubes and rods extending through one end of said receptacles; and the separation column being mounted about a column holder so that the cylindrical axes of said receptacles are radially oriented with respect to a central axis said column holder about which said column holder is rotatable, said column holder being fixed within a frame so as to be revolvable about a planetary axis spaced way form said central axis.
Claim 3
Dependent Claim
14 words
The planetary centrifuge of claim 1, wherein said mixing means comprises a solid rod.
Claim 4
Dependent Claim
16 words
The planetary centrifuge of claim 1, wherein said mixing means comprises one of said flow tubes.
Claim 5
Dependent Claim
29 words
The planetary centrifuge of claim 1, wherein said free end of said rod extends axially almost to one end of said receptacle most distal said fixed end of receptacle.
Claim 6
Dependent Claim
24 words
The planetary centrifuge of claim 1, wherein said plurality of receptacles are arranged in a plurality of longitudinally extending rows upon said column holder.
Claim 7
Dependent Claim
18 words
The planetary centrifuge of claim 5, wherein a weight is attached to the free end of said rod.
Claim 8
Dependent Claim
36 words
The planetary centrifuge of claim 1, wherein at least one end of said receptacle is sealed by a stopper, said flow tubes and rod connected to said receptacles extending through and being fixed within said stopper.
References Cited (Backward Citations)
US3856669A
Cited
US3830369A
Cited
US4046515A
Cited
US3994805A
Cited
US4058460A
Cited
US4151089A
Cited
US4228009A
Cited
US4422941A
Cited
US4510058A
Cited
US4487693A
Cited
US4551251A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-14 | 1993-02-13 | 1993-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-14 | 1997-02-13 | 1997-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-14 | 2001-02-13 | 2001-08-15 | $7700.00 | Window Closed / Lapsed |